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Cu(II) ionic liquid promoted Simple and Economical Synthesis of 1,4-disubstituted-1,2,3-triazoles with Low Catalyst Loading

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Abstract

In this work, we have described a very simple and low metal loading copper-based ionic liquid as solvent and catalyst for regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles. The proposed protocol proved its efficiency by showing excellent tolerance to a large array of electronically diverse substrates without the use of the external base, solvent and ligands. Moreover, from cytotoxicity analysis the catalyst was found to be non-toxic in nature due to extremely low loading of copper metal (0.1 mol %).

Graphical abstract

This work describes a very simple and low metal loading catalytic system for efficient synthesis of 1,4-disubstituted-1,2,3-triazoles. The synthesized copper based ionic liquid acted both as solvent and as catalyst. Cytotoxicity analysis indicates that the catalyst is non-toxic in nature due to extremely low loading of copper metal (0.1 mol%).

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Acknowledgement

The authors acknowledge the Department of Science and Technology for financial assistance under DST-FIST program and UGC, New Delhi for Special Assistance Programme (UGC-SAP) to the Department of Chemistry, Dibrugarh University. We sincerely thank the Defence Research Laboratory, Tezpur, for the cytotoxicity analysis of the catalyst.

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Authors and Affiliations

  1. Department of Chemistry, Dibrugarh University, Dibrugarh, Assam, India

    Parmita Phukan & Diganta Sarma

  2. Academy of Scientific and Innovative Research (AcSIR)-Central Salt and Marine Chemicals Research Institute Council of Scientific and Industrial Research (CSIR), Bhavnagar, Gujarat, India

    Akshay Kulshrestha & Arvind Kumar

  3. Defence Research Laboratory, Tezpur, Assam, India

    Srijita chakraborti & Pronobesh Chattopadhyay

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  1. Parmita Phukan
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  2. Akshay Kulshrestha
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  5. Pronobesh Chattopadhyay
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Correspondence to Diganta Sarma.

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Phukan, P., Kulshrestha, A., Kumar, A. et al. Cu(II) ionic liquid promoted Simple and Economical Synthesis of 1,4-disubstituted-1,2,3-triazoles with Low Catalyst Loading. J Chem Sci 133, 131 (2021). https://doi.org/10.1007/s12039-021-01980-9

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