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A facile one-pot synthesis of 1H-pyrano[2,3-d]pyrimidin-4(5H)-ones and evaluation of their Ct-DNA interaction, antibacterial and anti-inflammatory activity

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Abstract

In this paper, we reported the synthesis of coumarin-pyrimidine derivatives by a four-component reaction involving 4-hydroxycoumarin, aldehyde, thiobarbituric acid and piperidine in ethanol. All the synthesized compounds were well-characterized by IR, NMR and mass spectroscopic techniques. Further, to evaluate the biological potency of the synthesized compounds, initially, DNA cleavage studies were performed. Encouraged by the results obtained from the cleavage studies, the synthesized compounds were screened for in-vitro antibacterial and anti-inflammatory activity. From the biological activity results, it revealed that most of the synthesized compounds were found to exhibit potent antimicrobial and anti-inflammatory activity with least IC50 than compared with standard.

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Acknowledgements

One of the authors would like to acknowledge the Chairman, Department of Industrial Chemistry, Kuvempu University, Shankaraghatta for providing laboratory facilities.

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Authors and Affiliations

  1. Department of P G Studies and Research in Industrial Chemistry, Jnanasahyadri, Kuvempu University, Shankaraghatta, Shivamogga, 577451, Karnataka, India

    Mamata Devendra Naik

  2. Department of P.G. Studies and Research in Chemistry, Jnanasahyadri, Kuvempu University, Shankaraghatta, Shivamogga, 577451, Karnataka, India

    Yadav D Bodke

  3. Department of P.G. Studies and Research in Microbiology, Jnanasahyadri, Kuvempu University, Shankaraghatta, Shivamogga, 577451, Karnataka, India

    J Prashantha

  4. ITC Life Science and Technology Centre, Bangalore, India

    Jayanth K Naik

Authors
  1. Mamata Devendra Naik
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  2. Yadav D Bodke
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  3. J Prashantha
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  4. Jayanth K Naik
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Correspondence to Yadav D Bodke.

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Naik, M.D., Bodke, Y.D., Prashantha, J. et al. A facile one-pot synthesis of 1H-pyrano[2,3-d]pyrimidin-4(5H)-ones and evaluation of their Ct-DNA interaction, antibacterial and anti-inflammatory activity. J Chem Sci 133, 17 (2021). https://doi.org/10.1007/s12039-020-01875-1

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  • DOI: https://doi.org/10.1007/s12039-020-01875-1

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