Skip to main content
Log in

Occurrence, detection and detoxification of mycotoxins

  • Review
  • Published:
Journal of Biosciences Aims and scope Submit manuscript

ABSTRACT

Mycotoxins have been identified as important toxins affecting animal species and humans ever since the discovery of aflatoxin B1 in 1960. Mycotoxigenic fungi are ubiquitous in nature and are held responsible for economic loss as they decrease crop yield and quality of food. The presence of fungi and their mycotoxins are reported not only in food grains but also in medicinal herbs and processed foods. Since prevention is not always possible, detoxification of mycotoxins have been attempted using several means; however, only few have been accepted for practical use, e.g. ammonia in the corn industry. Organizations such as the World Health Organization, US Food and Drug Administration and European Union have set regulations and safety limits of important mycotoxins, viz. aflatoxins, fusarium toxins, ochratoxin, patulin zearalenone, etc., to ensure the safety of the consumers. This review article is a brief and up-to-date account of the occurrence, detection and detoxification of mycotoxins for those interested in and considering research in this area.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Aiko V and Mehta A 2013a Control of Aspergillus flavus and aflatoxin production with spices in culture medium and rice. World Mycotoxin J. 6 43–50

    Article  CAS  Google Scholar 

  • Aiko V and Mehta A 2013b Inhibitory effect of clove (Syzygium aromaticum) on the growth of Penicillium citrinum and citrinin production. J. Food Saf. 33 440–444

    Article  Google Scholar 

  • Aiko V, Edamana P and Mehta A 2015 Decomposition and detoxification of aflatoxin B1 by lactic acid. J. Sci. Food Agric. doi:10.1002/jsfa.7304

    PubMed  Google Scholar 

  • Akiyama H, Uraroongroj M, Miyahara M, Goda Y and Toyoda M 1998 Quantitation of fumonisins in corn by HPLC with o-phthalaldehyde postcolumn derivatisation and their identification by LC/MS. Mycopathologia 140 157–161

    Article  CAS  Google Scholar 

  • Alborch L, Bragulat MR, Castella G, Abarca ML and Cabanes FJ 2012 Mycobiota and mycotoxin contamination of maize flours and popcorn kernels for human consumption commercialized in Spain. Food Microbiol. 32 97–103

    Article  CAS  PubMed  Google Scholar 

  • Altug T, Yousef AE and Martin EH 1990 Degradation of aflatoxin B1 in dried figs by sodium bisulfite with or without heat, ultraviolet energy or hydrogen peroxide. J. Food Prot. 53 581–582

    CAS  Google Scholar 

  • Applegate KL and Chipley JR 1974 Effect of 60CoGI on aflatoxin B1 and B2 production by Aspergillus flavus. Mycologia 66 436–445

    Article  CAS  PubMed  Google Scholar 

  • Applegate KL and Chipley JR 1976 Production of ochratoxin A by Aspergillus ochraceus NRRL-3174 before and after exposure with 60Co irradiation. Appl. Environ. Microbiol. 31 349–353

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bankole SA and Joda AO 2004 Effect of lemon grass (Cymbopogon citratus Stapf) powder and essential oil on mould deterioration and aflatoxin contamination of melon seeds (Colocynthis citrullus L.). Afr. J. Biotechnol. 3 52–59

    Article  CAS  Google Scholar 

  • Bansod S and Rai M 2008 Antifungal activity of essential oils from Indian medicinal plants against human pathogenic Aspergillus fumigates and A. niger. World J. Med. Sci. 3 81–88

    Google Scholar 

  • Betina V 1985 Thin-layer chromatography of mycotoxins. J. Chromatogr. 334 211–276

    Article  CAS  PubMed  Google Scholar 

  • Bhat RV, Ramakrishna Y, Beedu SR and Munshi KL 1989 Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat products in Kashmir valley, India. Lancet 333 35–37

    Article  Google Scholar 

  • Binder EM, Tan LM, Chin LJ, Handl J and Richard J 2007 Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients. Anim. Feed Sci. Technol. 137 265–282

    Article  CAS  Google Scholar 

  • Blount WP 1961 Turkey ‘X’ disease. J. Brit. Turkey Federation. 9 55–58

    Google Scholar 

  • Bokhari FM 2007 Spices mycobiota and mycotoxins available in Saudi Arabia and their abilities to inhibit growth of some toxigenic fungi. Mycobiology 35 47–53

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Braunberg RC, Gantt O, Barton C and Friedman L 1992 In vitro effects of the nephotoxins ochratoxin A and citrinin upon biochemical function of porcine kidney. Arch. Environ. Contam. Toxicol. 22 464–470

    Article  CAS  PubMed  Google Scholar 

  • Bugno A, Almodovar AAB, Pereira TC, Pinto TJA and Sabino M 2006 Occurrence of toxigenic fungi in herbal drugs. Braz. J. Microbiol. 37 47–51

    Article  Google Scholar 

  • Bullerman LB and Bianchini A 2007 Stability of mycotoxins during food processing. Int. J. Food Microbiol. 119 140–146

    Article  CAS  PubMed  Google Scholar 

  • Bullerman LB, Lieu FY and Seier SA 1977 Inhibition of growth and aflatoxin production by cinnamon and clove oil, cinnamic aldehyde and eugenol. J. Food Sci. 42 1107–1109

    Article  CAS  Google Scholar 

  • Camou-Arriola JP and Price RL 1989 Destruction of aflatoxin and reduction of mutagenicity of naturally contaminated corn during production of corn snack. J. Food Prot. 52 814–817

    CAS  Google Scholar 

  • Candlish AAG, Aidoo KE, Smith JE and Pearson SM 2000 A limited survey of aflatoxins and fumonisins in retail maize-based products in the UK using immunoassay detection. Mycotoxin Res. 16 2–8

    Article  CAS  PubMed  Google Scholar 

  • Castelo MM, Sumner SS and Bullerman LB 1998 Stability of fumonisins in thermally processed corn products. J. Food Prot. 61 1030–1033

    CAS  PubMed  Google Scholar 

  • Cavaliere C, D’Ascenzo G, Foglia P, Pastorini E, Samperi R and Lagana A 2005 Determination of type B trichothecenes and macrocyclic lactone mycotoxins in field contaminated maize. Food Chem. 92 559–568

    Article  CAS  Google Scholar 

  • Cho SH, Lee CH, Jang MR, Son YW, Lee SM, Choi IS, Kim SM and Kim DB 2008 Aflatoxin contamination in spices and processed spice products commercialized in Korea. Food Chem. 107 1283–1288

    Article  CAS  Google Scholar 

  • Chourasia HK 1995 Mycobiota and mycotoxins in herbal drugs of Indian pharmaceutical industries. Mycol. Res. 99 697–703

    Article  CAS  Google Scholar 

  • Chu FS, Chang CC, Ashoor SH and Prentice N 1975 Stability of aflatoxin B1 and ochratoxin A in brewing. Appl. Microbiol. 29 313–316

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ciegler A and Peterson RE 1968 Aflatoxin detoxification: hydroxydihydro-Aflatoxin B1. Appl. Microbiol. 16 665–666

    CAS  PubMed Central  PubMed  Google Scholar 

  • Colvin BM and Harrison LR 1992 Fumonisin-induced pulmonary edema and hydrothorax in swine. Mycopathologia 117 79–82

    Article  CAS  PubMed  Google Scholar 

  • Council for Agricultural Science and Technology (CAST) 2003 Mycotoxins: risks in plant, animal and human systems, Task force report, No.139. (Ames: Council for Agricultural Science and Technology) pp 1–191

  • Croteau SM, Prelusky DB and Trenholm HC 1994 Analysis of trichothecene mycotoxins by gas chromatography with electron capture detection. J. Agric. Food Chem. 42 928–933

    Article  CAS  Google Scholar 

  • Croy RG, Essigmann JM, Reinhold VN and Wogan GN 1978 Identification of the principal aflatoxin B1-DNA adduct formed in vitro in rat liver. Proc. Natl. Acad. Sci. USA 75 1745–1749

  • Das C and Mishra HN 2000 In vitro degradation of aflatoxin B1 by horseradish peroxidase. Food Chem. 68 309–313

    Article  CAS  Google Scholar 

  • Dell MPK, Haswell SJ, Roch OG, Coker RD, Medlock VFP and Tomlins K 1990 Analytical methodology for the determination of aflatoxins in peanut butter: comparison of high-performance thin-layer chromatographic, enzyme-linked immunosorbent assay and high-performance liquid chromatographic methods. Analyst 115 1435–1439

    Article  CAS  PubMed  Google Scholar 

  • Delmulle BS, De Saeger SM, Sibanda L, Barna-Vetro I and Van Peteghem CH 2005 Development of an immunoassay-based lateral flow dipstick for the rapid detection of aflatoxin B1 in pig feed. J. Agric. Food Chem. 53 3364–3368

    Article  CAS  PubMed  Google Scholar 

  • Doyle MP and Marth EH 1978 Aflatoxin is degraded by mycelia from toxigenic and non-toxigenic strains of aspergilli grown on different substrates. Mycopathologia 63 145–153

  • Doyle MP and Marth EH 1979 Peroxidase activity in mycelia of Aspergillus parasiticus that degrade aflatoxin. Appl. Microbiol. Biotechnol. 7 211–217

    Article  CAS  Google Scholar 

  • El-Banna AA and Scott PM 1983 Fate of mycotoxins during processing of foodstuffs I- aflatoxin B1 during making of Egyptian bread. J. Food Prot. 46 301–304

    CAS  Google Scholar 

  • El-Nezami H, Kankaanpaa P, Salminen S and Ahokas J 1998 Ability of lactic acid bacteria to bind to a common food carcinogen, aflatoxin B-1. Food Chem. Toxicol. 36 321–326

    Article  CAS  PubMed  Google Scholar 

  • El-Nezami H, Polychronaki N, Salminen S and Mykkanen H 2002 Binding rather than metabolism may explain the interaction of two food-grade Lactobacillus strains with zearalenone and its derivatives α-zearalenone. Appl. Environ. Microbiol. 68 3545–3549

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Feinberg B and McLaughlin CS 1989 Biochemical mechanism of action of trichothecene mycotoxins; in Trichothecene mycotoxicoses: pathophysiologic effects, Vol. I (ed) VR Beasley (Boca Raton: CRC Press) pp 27–35

    Google Scholar 

  • Fukal L 1990 A survey of cereals, cereal products, feedstuffs and porcine kidneys for ochratoxin A by radioimmunoassay. Food Addit. Contam. 7 253–258

    Article  CAS  PubMed  Google Scholar 

  • Gandomi H, Misaghi A, Basti AA, Bokaei S, Khosravi A, Abbasifar A and Javan AJ 2009 Effect of Zataria multiflora Boiss. Essential oil on growth and aflatoxin formation by Aspergillus flavus in culture media and cheese. Food Chem. Toxicol. 47 2397–2400

    Article  CAS  PubMed  Google Scholar 

  • Gerding J, Ali N, Schwartzbord J, Cramer B, Brown DL, Degen GH and Humpf HU 2015 A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach. Mycotoxin Res. 31 127–136

    Article  CAS  PubMed  Google Scholar 

  • Gray SL, Lackey BR, Tate PL, Riley MB and Camper ND 2004 Mycotoxins in root extract of American and Asian ginseng bind estrogen receptors α and β. Exp. Biol. Med. 229 560–568

    CAS  Google Scholar 

  • Hameed HG 1993 Extrusion and chemical treatments for destruction of aflatoxin in naturally-contaminated corn, Ph.D. thesis, University of Arizona

  • Hamid AB and Smith JE 1987 Degradation of aflatoxin by Aspergillus flavus. J. Gen. Microbiol. 133 2023–2029

    CAS  PubMed  Google Scholar 

  • Hasan HAH 1996 Destruction of aflatoxin B1 on sorghum grain with acids, salts and ammonia derivatives. Cryptogam. Mycol. 17 129–134

    Google Scholar 

  • Hernandez-Hierro JM, Garcia-Villanova RJ and Gonzalez-Martin I 2008 Potential of near infrared spectroscopy for the analysis of mycotoxins applied to naturally contaminated red paprika found in the Spanish market. Anal. Chim. Acta. 622 189–194

    Article  CAS  PubMed  Google Scholar 

  • Herzallah SM 2009 Determination of aflatoxins in eggs, milk, meat and meat products using HPLC fluorescent and UV detectors. Food Chem. 114 1141–1146

    Article  CAS  Google Scholar 

  • Hu W, Chen H, Zhang H, He G, Li X, Zhang X, Liu Y and Li CM 2014 Sensitive detection of multiple mycotoxins by SPRi with gold nanoparticles as signal amplification tags. J. Colloid Interface Sci. 431 71–75

    Article  CAS  PubMed  Google Scholar 

  • Huang F, Zhao J, Zhou L, Wang J, Gong Y, Chen X, Guo Z, Wang Q, et al. 2010 Antifungal activity of the essential oil of Illicium verum fruit and its main component trans-Anethole. Molecules 15 7558–7569

    Article  CAS  PubMed  Google Scholar 

  • Huang LC, Zheng N, Zheng BQ, Wen F, Cheng JB, Han RW, Xu XM, Li SL, et al. 2014 Simultaneous determination of aflatoxin M1, ochratoxin A, zearalenone and α-zearalenol in link by UHPLC-MS/MS. Anal. Methods 146 242–249

    CAS  Google Scholar 

  • Hult K, Piestina R, Habazin-Novak V, Radic B and Ceovic S 1982 Ochratoxin A in human blood and Balkan endemic nephropathy. Arch. Toxicol. 51 313–321

    Article  CAS  Google Scholar 

  • Hussaini AM, Timothy AG, Olufunmilayo HA, Ezekiel AS and Godwin HO 2007 Fungi and some mycotoxins contaminating rice (Oryza sativa) in Niger state, Nigeria. Afr. J. Biotechnol. 6 99–108

    CAS  Google Scholar 

  • International Agency for Research on Cancer (IARC) 2002 Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. Monograph on the evaluation of carcinogenic risk to humans, Vol. 82 (Lyon: IARC)

    Google Scholar 

  • Jayashree T and Subramanyam C 1999 Antiaflatoxigenic activity of eugenol is due to inhibition of lipid peroxidation. Lett. Appl. Microbiol. 28 179–183

    Article  CAS  PubMed  Google Scholar 

  • Kitabatake N, Trivedi AB and Doi E 1991 Thermal decomposition and detoxification of Citrinin under various moisture conditions. J. Agric. Food Chem. 39 2240–2244

    Article  CAS  Google Scholar 

  • Kolosova AY, De Saeger S, Sibanda L, Verheijen R and Van Peteghem C 2007 Development of a colloidal gold-based lateral-flow immunoassay for the rapid simultaneous detection of zearalenone and deoxynivalenol. Anal. Bioanal. Chem. 389 2103–2107

    Article  CAS  PubMed  Google Scholar 

  • Kos G, Lohninger H and Krska R 2003 Development of a method for the determination of Fusarium fungi on corn using mid-infrared spectroscopy with attenuated total reflection and chemometrics. Anal. Chem. 75 1211–1217

    Article  CAS  PubMed  Google Scholar 

  • Krishnamachari KAVR, Bhat RV, Nagarajan V and Tilak TBG 1975 Hepatitis due to aflatoxicosis. An outbreak in western India. Lancet 1 1061–1063

  • Kuiper-Goodman T 1998 Food safety: mycotoxins and phycotoxins in perspective; in Mycotoxins and Phycotoxins- development in chemistry, toxicology and food safety. Proceedings of the IX IUPAC International Symposium (eds) M Minaglia, H Van Egmond, C Brera and J Gilbert (Fort Collins: Alaken Inc) pp 25–48

    Google Scholar 

  • Kuiper-Goodman T and Scott PM 1989 Risk assessment of the mycotoxin ochratoxin A. Biomed. Environ. Sci. 2 179–248

    CAS  PubMed  Google Scholar 

  • Kumar A, Shukla R, Singh P and Dubey NK 2010 Chemical composition, antifungal and antiaflatoxigenic activities of Ocimum sanctum L. essential oil and its safety assessment as plant based antimicrobial. Food Chem. Toxicol. 48 539–543

    Article  CAS  PubMed  Google Scholar 

  • Kurtz HJ and Mirocha J 1978 Zearalenone (F2) induced estrogenic syndrome in swine; in Mycotoxic fungi, mycotoxins, mycotoxicoses, Vol. 2 (eds) TD Wyllie and LG Morehouse (New York: Marcel Dekker) pp 1256–1264

    Google Scholar 

  • Lee SL and Cucullu AF 1978 Conversion of aflatoxin B1 to aflatoxin D1 in ammoniated peanut and cottonseed meals. J. Agric. Food Chem. 26 881–884

    Article  CAS  PubMed  Google Scholar 

  • Levi C 1980 Mycotoxins in coffee. J. AOAC Int. 63 1282–1285

    CAS  Google Scholar 

  • Lillehoj EB, Ciegler A and Hall HH 1967 Aflatoxin B1 uptake by Flavobacterium aurantiacum and resulting toxic effects. J. Bacteriol. 93 464–4715

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lin L, Zhang J, Wang P, Wang Y and Chen J 1998 Thin-layer chromatography of mycotoxins and comparison with other chromatographic methods. J. Chromatogr. A. 815 3–20

    Article  CAS  PubMed  Google Scholar 

  • Line EJ, Brackett RE and Wilkinson RE 1994 Evidence for degradation of aflatoxin B1 by Flavobacterium aurantiacum. J. Food Prot. 57 788–791

    CAS  Google Scholar 

  • Liu DL, Yao DS, Liang R, Ma L, Cheng WA and Gu LQ 1998 Detoxification of aflatoxin B1 by enzymes isolated from Armellaria tabescens. Food Chem. Toxicol. 36 563–574

    Article  CAS  PubMed  Google Scholar 

  • Liu R, Chang M, Jin Q, Huang J, Liu Y and Wang X 2011 Degradation of aflatoxin B1 in aqueous medium through UV irradiation. Eur. Food Res. Technol. 233 1007–1012

    Article  CAS  Google Scholar 

  • Maeba H, Takamoto Y, Kamimura M and Miura T 1988 Destruction and detoxification of aflatoxins with ozone. J. Food Sci. 53 667–668

    Article  CAS  Google Scholar 

  • Magan N and Olsen M 2004 Mycotoxins in food: detection and control (Woodhead Publishing Series in Food Science, Technology and Nutrition)

  • Mahjoub AM and Bullerman LB 1988 Effects of storage time, sunlight, temperature and frying on stability of aflatoxin B1 in olive oil. Lebensm. Wiss. Technol. 21 429–435

    Google Scholar 

  • Mann GE, Codifer LP Jr and Dollear FG 1967 Effects of heat on aflatoxin in oilseed meals. J. Agric. Food Chem. 15 1090–1092

    Article  CAS  Google Scholar 

  • Marasas WFO, Kellerman TS, Gelderblom WCA, Coetzer JEW, Thiel PG and Van der Lugt JJ 1988 Leukoencephalomalacia in horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onederstepoort J. Vet. Res. 55 197–203

    CAS  Google Scholar 

  • McLean M and Dutton MF 1995 Cellular interactions and metabolism of aflatoxin: an update. Pharmacol. Ther. 65 163–192

  • Megalla SE and Mohran MA 1984 Fate of aflatoxin B1 in fermented dairy products. Mycopathologia 88 27–29

    Article  CAS  PubMed  Google Scholar 

  • Meija EG, Pina GL and Gomez MR 1997 Antimutagenic activity of natural xanthrophylls against aflatoxin B1 in Salmonella typhimurium. Environ. Mol. Mutagen. 30 346–353

    Article  Google Scholar 

  • Milanez TV and Valente-Soares LM 2006 Gas chromatography-mass spectrometry determination of trichothecene mycotoxins in commercial corn harvested in the state of Sao Paulo; Brazil. J. Braz. Chem. Soc. 17 412–416

    Article  CAS  Google Scholar 

  • Molinelli A, Grossalber K, Fuhrer M, Baumgartner S, Sulyok M and Krska R 2008 Development of qualitative and semiqualitative immunoassay-based rapid strip tests for the detection of T-2 toxin in wheat and oat. J. Agric. Food Chem. 56 2589–2594

    Article  CAS  PubMed  Google Scholar 

  • Moss MO 2002 Risk assessment for aflatoxins in foodstuffs. Int. Biodeterior. Biodegrad. 50 137–142

    Article  CAS  Google Scholar 

  • Mushtaq M, Sultana B, Anwar F, Khan MZ and Ashrafuzzaman M 2012 Occurrence of aflatoxins in selected processed foods from Pakistan. Int. J. Mol. Sci. 13 8324–8337

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Muture BN and Oqana G 2005 Aflatoxin levels in maize products during the 2004 food poisoning outbreak in Eastern Province of Kenya. East Afr. Med. J. 82 275–279

    Article  CAS  PubMed  Google Scholar 

  • Nguyen MT, Tozlovanu M, Tran TL and Pfohl-Leszkowicz A 2007 Occurrence of aflatoxin B1, citrinin and ochratoxin A in rice in five provinces of the central region of Vietnam. Food Chem. 105 42–47

    Article  CAS  Google Scholar 

  • Olsen M 1989 Metabolism of zearalenone in farm animals; in Fusarium mycotoxins, taxonomy and pathogenicity, 1st edition (eds) J Chelkowsi (Amsterdam-Oxford-New York) pp 167–177

  • Osman NA, Abdelgadir AM, Moss MO and Bener A 1999 Aflatoxin contamination of rice in the United Arab Emirates. Mycotoxin Res. 15 39–44

    Article  CAS  PubMed  Google Scholar 

  • Pal A and Dhar TK 2004 An analytical device for on-site immunoassay. Demonstration of its applicability in semiquantitative detection of aflatoxin B1 in a batch of samples with ultrahigh sensitivity. Anal. Chem. 76 98–104

    Article  CAS  PubMed  Google Scholar 

  • Paster N, Barkai-Golan R and Padova R 1985 Effect of gamma radiation on ochratoxin production by the fungus Aspergillus ochraceus. J. Sci. Food Agric. 36 445–449

    Article  CAS  Google Scholar 

  • Peraica M, Radic B, Lucic A and Pavlovic M 1999 Toxic effects of mycotoxins in humans. Bull. World Health Organ. 77 754–766

    CAS  PubMed Central  PubMed  Google Scholar 

  • Pettersson H and Aberg L 2003 Near-infrared spectroscopy for determination of mycotoxins in cereals. Food Control. 14 229–232

    Article  CAS  Google Scholar 

  • Pfohl-Leszkowicz A, Grosse Y, Castegnaro M, Nicolov IG, Chernozemsky IN, Bartsch H, Betbeder AM, Creppy EE, et al. 1993 Ochratoxin A-related DNA adducts in urinary tract tumours of Bulgarian subjects. IARC Sci. Publ. 124 141–148

    CAS  PubMed  Google Scholar 

  • Pinto E, Vale-Silva L, Cavaleiro C and Salgueiro L 2009 Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. J. Med. Microbiol. 58 1454–1462

    Article  PubMed  Google Scholar 

  • Pons WA Jr and Franz AO Jr 1978 High performance liquid chromatographic determination of aflatoxins in peanut products. J. AOAC Int. 61 793–800

    CAS  Google Scholar 

  • Price RL and Jorgensen KV 1985 Effects of processing on aflatoxin levels and on mutagenic potential of tortillas made from naturally contaminated corn. J. Food Sci. 50 347–357

    Article  CAS  Google Scholar 

  • Prudente AD Jr and King JM 2002 Efficacy and safety evaluation of ozonation to degrade aflatoxin in corn. J. Food Sci. 67 2866–2872

    Article  CAS  Google Scholar 

  • Rauscher R, Edenharder R and Platt KL 1998 In vitro mutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids. Mutat. Res. 413 129–142

    Article  CAS  PubMed  Google Scholar 

  • Reddy KRN, Reddy CS and Muralidharan K 2009 Detection of Aspergillus spp. and aflatoxin B1 in rice in India. Food Microbiol. 26 27–31

    Article  CAS  PubMed  Google Scholar 

  • Richard JL 2003 Mycotoxins and human disease; in Clinical mycology (eds) EJ Anaissie, MR McGinnis and MA Pfaller (New York: Churchill Livingstone) pp 589–598

    Google Scholar 

  • Rizzo I, Vedoya G, Maurutto S, Haidukowski M and Varsavsky E 2004 Assessment of toxigenic fungi on Argentinean medicinal herbs. Microbiol. Res. 159 113–120

    Article  CAS  PubMed  Google Scholar 

  • Rodriquez-Carraso Y, Berrado H, Font G and Manes J 2012 Multi-mycotoxin analysis in wheat semolina using an acetonitrile-based extraction procedure and gas chromatography-tandem spectrometry. J. Chromatogr. A 1270 28–40

  • Romagnoli B, Menna V, Gruppioni N and Bergamini C 2007 Aflatoxins in spices, aromatic herbs, herb-teas and medicinal plant marketed in Italy. Food Control. 18 697–701

    Article  CAS  Google Scholar 

  • Roy AK and Kumari V 1991 Aflatoxin and citrinin in seeds of some medicinal plants under storage. Pharm. Biol. 29 62–65

    Article  CAS  Google Scholar 

  • Saha D, Acharya D, Roy D, Shrestha D and Dhar TK 2007 Simultaneous enzyme immunoassay for the screening of aflatoxin B1 and ochratoxin A in chili samples. Anal. Chim. Acta 584 343–349

  • Santos L, Marin S, Sanchis V and Ramos AJ 2009 Screening of mycotoxin multicontamination in medicinal and aromatic herbs sampled in Spain. J. Sci. Food Agric. 89 1802–1807

    Article  CAS  Google Scholar 

  • Scott PM 1995 Mycotoxin methodology. Food Addit. Contam. 12 395–403

    Article  CAS  PubMed  Google Scholar 

  • Serralheiro ML and Quinta ML 1985 Rapid thin layer chromatographic determination of aflatoxin M1 in powdered milk. J. AOAC Int. 68 952–954

    CAS  Google Scholar 

  • Sewram V, Shephard GS, Merwe LVD and Jacobs TV 2006 Mycotoxin contamination of dietary and medicinal wild plants in the Eastern Cape Province of South Africa. J. Agric. Food Chem. 54 5688–5693

    Article  CAS  PubMed  Google Scholar 

  • Shantha T 1999 Fungal degradation of aflatoxin B1. Nat. Toxins. 7 175–178

    Article  CAS  PubMed  Google Scholar 

  • Shantha T and Sreenivasa Murthy V 1977 Photo-degradation of aflatoxin in groundnut oil. Indian J. Technol. 15 453–454

    CAS  Google Scholar 

  • Shukla RS, Verma RJ and Mehta DN 2002 Kinetic and mechanistic investigations on reductions of aflatoxins by lactic acid. Bioorg. Med. Chem. Lett. 12 2737–2741

    Article  CAS  PubMed  Google Scholar 

  • Singh VP 1998 Enzymatic degradation of aflatoxins in shake flask cultures of A. flavus CMI 1102566: A possible role of peroxidase in biological control mechanism. J. Phytol. Res. 11 7–10

    CAS  Google Scholar 

  • Singh J, Reen RK and Wrehel FJ 1994 Piperine, a major ingredient of black and long peppers, protects against aflatoxin B1-induced cytotoxicity and micronuclei formation H411EC3 rat hepatoma cells. Cancer Lett. 86 195–200

    Article  CAS  PubMed  Google Scholar 

  • Spanjer MC, Rensen PM and Scholten JM 2008 LC-MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs. Food Addit. Contam. Part A Chem. Anal. Control Exp. Risk Assess. 25 472–489

  • Stack ME and Pohland AE 1975 Collaborative study of a method for chemical confirmation of the identity of aflatoxin. J. AOAC Int. 58 110–113

    CAS  Google Scholar 

  • Sugita-Konishi Y, Nakajima M, Tabata S, Ishikuro E, Tanaka T, Norizuki H, Itoh Y, Aoyama K, et al. 2006 Occurrence of aflatoxins, ochratoxins A, and fumonisins in retail foods in Japan. J. Food Prot. 69 1365–1370

    CAS  PubMed  Google Scholar 

  • Sun PS and Chu FS 1977 A simple solid-phase radioimmunoassay doe aflatoxin B1. J. Food Saf. 1 67–75

    Article  CAS  Google Scholar 

  • Teshima R, Hirai K, Sato M, Ikebuchi H, Ichinoe M and Terao T 1990 Radioimmunoassay of nivalenol in barley. Appl. Environ. Microbiol. 56 764–768

    CAS  PubMed Central  PubMed  Google Scholar 

  • Thirumala-Devi K, Mayo MA, Reddy G, Emmanuel KE, Larondelle Y and Reddy DVR 2001 Occurrence of ochratoxin A in black pepper, coriander, ginger and turmeric in India. Food Addit. Contam. 18 830–835

    Article  CAS  PubMed  Google Scholar 

  • Tian J, Huang B, Luo Z, Zeng H, Ban X, He J and Wang Y 2011 The control of Aspergillus flavus with Cinnamomum jensenianum Hand.-Mazz essential oil and its potential use as a food preservative. Food Chem. 130 520–527

    Article  CAS  Google Scholar 

  • Torres MR, Sanchis V and Ramos AJ 1998 Occurrence of fumonisins in Spanish beers analyzed by an enzyme-linked immunosorbent assay method. Int. J. Food Microbiol. 39 139–143

    Article  CAS  PubMed  Google Scholar 

  • Tosch D, Waltking AE and Schlesier JF 1984 Comparison of liquid chromatography and high performance thin layer chromatography for determination of aflatoxin in peanut products. J. AOAC Int. 67 337–339

    CAS  Google Scholar 

  • Trivedi AB, Doi E and Kitabatake N 1992 Detoxification of ochratoxin A on heating under acidic and alkaline conditions. Biosci. Biotechnol. Biochem. 56 741–745

    Article  CAS  Google Scholar 

  • Trucksess MW, Weaver CM, Oles CJ, D’Ovidio K and Rader JI 2006 Determination of aflatoxins and ochratoxin A in ginseng and other botanical roots by immunoaffinity column cleanup and liquid chromatography with fluorescence detection. J. AOAC Int. 89 624–630

    CAS  PubMed Central  PubMed  Google Scholar 

  • Trung TS, Tabuc C, Bailly S, Querin A, Guerre P and Bailly JD 2008 Fungal mycoflora and contamination of maize from Vietnam with aflatoxin B1 and fumonisin B1. World Mycotoxin J. 1 87–94

    Article  CAS  Google Scholar 

  • Visconti A, Pascale M and Centonze G 1999 Determination of ochratoxin A in wine by means of immunoaffinity column clean-up and high performance liquid chromatography. J. Chromatogr. A 864 89–101

  • Voss KA, Riley RT, Moore ND and Burns TD 2012 Alkaline cooking (nixtamalization) and the reduction in the in vivo toxicity of fumonisin-contaminated corn in a rat feeding bioassay. Food Addit. Contam., Part A 30 1415–1421

  • Vrabcheva T, Usleber E, Dietrich R and Martlbauer E 2000 Co-occurrence of ochratoxin A and citrinin in cereals from Bulgarian villages with a history of Balkan endemic nephropathy. J. Agric. Food Chem. 48 2483–2488

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Dostalek J and Knoll W 2009 Long range surface plasmon-enhanced fluorescence spectroscopy for the detection of aflatoxin M1 in milk. Biosens. Bioelectron. 24 2264–2267

    Article  CAS  PubMed  Google Scholar 

  • Wang SK, Wang TT, Huang GL, Shi RF, Yang LG and Sun GJ 2014 Stimulation of the proliferation of human normal esophageal epithelial cells by fumonisin B1 and its mechanism. Exp. Ther. Med. 7 55–60

    PubMed Central  PubMed  Google Scholar 

  • Wattanapat R, Nakayama T and Beuchat LR 1995 Characteristics of acid hydrolysate from defatted peanut flour. J. Food Sci. 60 443–445

    Article  CAS  Google Scholar 

  • Wild CP and Gong YY 2010 Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis 31 71–82

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Williams KR and Dutton MF 1988 Destruction of Aflatoxin during the production of hydrolysed vegetable protein. J. Food Prot. 51 887–891

    CAS  Google Scholar 

  • Zhang DH, Li PW, Zhang Q, Yang Y, Zhang W, Guan D and Ding XX 2012 Extract-free immunochromatographic assay for on-site tests of aflatoxin M1 in milk. Anal. Methods 4 3307–3313

  • Zuoxin L, Junxia G and Jiujiang Y 2006 Aflatoxin in stored maize and rice grains in Liaoning Province, China. J. Stored Prod. Res. 42 468–479

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alka Mehta.

Additional information

[Aiko V and Mehta A 2015 Occurrence, detection and detoxification of mycotoxins. J. Biosci.] DOI 10.1007/s12038-015-9569-6

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Aiko, V., Mehta, A. Occurrence, detection and detoxification of mycotoxins. J Biosci 40, 943–954 (2015). https://doi.org/10.1007/s12038-015-9569-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12038-015-9569-6

Keywords

Navigation