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Association of DISC1 Polymorphisms with Late-Onset Alzheimer’s Disease in Northern Han Chinese

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Abstract

The disrupted-in-schizophrenia-1 (DISC1) is a candidate gene for psychiatric diseases and plays various roles in brain development. It has been reported as a candidate gene for Alzheimer's disease (AD) in a recent large genome-wide association study in Caucasians. To explore the associations between DISC1 and AD, we performed a case–control study including 2318 subjects in Northern Han Chinese. We found that one single nucleotide polymorphism (rs6675281) was associated with the risk of late-onset Alzheimer’s disease (LOAD) in northern Han Chinese population. As for rs821616 and rs3738401, no association was detected with LOAD. In conclusion, DISC1 increased the risk for LOAD in northern Han Chinese population.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (81471309, 81371406, 81571245, and 81501103), the Shandong Provincial Outstanding Medical Academic Professional Program, Qingdao Key Health Discipline Development Fund, Qingdao Outstanding Health Professional Development Fund, and Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders.

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Authors and Affiliations

  1. Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, Shandong Province, 266071, People’s Republic of China

    Xiao-Yan Zhang, Meng-Shan Tan, Yu Wan, Chen-Chen Tan, Zi-Xuan Wang, Lan Tan & Jin-Tai Yu

  2. Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, People’s Republic of China

    Hui-Fu Wang & Lan Tan

  3. Department of Geriatric, Qingdao Mental Health Center, Qingdao, 266034, China

    Ling-Li Kong & Zhan-Jie Zheng

  4. Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, People’s Republic of China

    Wei Zhang

  5. College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, 266000, China

    Lin Tan

  6. Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China

    Teng Jiang

  7. Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, 1207, San Francisco, CA, 94158, USA

    Jin-Tai Yu

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  1. Xiao-Yan Zhang
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  2. Hui-Fu Wang
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  4. Yu Wan
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  7. Chen-Chen Tan
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  8. Wei Zhang
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  10. Lin Tan
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  11. Teng Jiang
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  12. Lan Tan
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Correspondence to Lan Tan or Jin-Tai Yu.

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Xiao-Yan Zhang and Hui-Fu Wang are both co-first authors.

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Zhang, XY., Wang, HF., Tan, MS. et al. Association of DISC1 Polymorphisms with Late-Onset Alzheimer’s Disease in Northern Han Chinese. Mol Neurobiol 54, 2922–2927 (2017). https://doi.org/10.1007/s12035-016-9881-7

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  • DOI: https://doi.org/10.1007/s12035-016-9881-7

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