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Hyperglycemia and Mortality Risk in Patients with Primary Intracerebral Hemorrhage: A Meta-Analysis

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Abstract

Hyperglycemia may be associated with worse functional outcomes in patients with primary intracerebral hemorrhage. We performed a systematic review and meta-analysis to investigate the relationship between hyperglycemia and mortality risk in patients with primary intracerebral hemorrhage. We searched PubMed and Embase databases for studies investigating the association between hyperglycemia and mortality risk in patients with primary intracerebral hemorrhage. We estimated the pooled relative risk (RR) with its 95 % confidence interval (95 % CI) to assess the impact of hyperglycemia on mortality risk. Seventeen studies with a total of 6527 primary intracerebral hemorrhage patients were included. Meta-analysis of those studies showed that hyperglycemia significantly increased risk of mortality in patients with primary intracerebral hemorrhage (RR = 2.36, 95 % CI 1.79–3.12). Subgroup analysis by time of follow-up showed that hyperglycemia significantly increased risk of short-term mortality (RR = 3.97, 95 % CI 2.13–7.43) and long-term mortality (RR = 1.53, 95 % CI 1.14–2.05). The RR of mortality for per 1-mmol/L increment in glucose level was 1.14 (95 % CI 1.06–1.22). In patients with primary intracerebral hemorrhage, hyperglycemia significantly increases risk of both short-term mortality and long-term mortality.

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Acknowledgments

There was no source of funding in the study. We thank the authors of included studies for the useful data.

Conflict of Interests

None of the authors have any conflict of interests to declare.

Compliance with Ethical Standards

None of the authors have any conflict of interests to declare. Our meta-analysis didn’t involve human participants or animals, and no informed consent was needed.

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Authors and Affiliations

  1. Neurosurgery Department, The First Affiliated Hospital of General Hospital of PLA, Beijing, 100048, China

    Xiaoming Guo, Zhiwen Zhang, Shouchun Li & Lizhi Zhang

  2. Neurology Department, The First Affiliated Hospital of General Hospital of PLA, Beijing, 100048, China

    Helin Li

  3. Neurosurgery Department, Air Force General Hospital of PLA, Beijing, 100048, China

    Jiajing Zhang

  4. Department of Medicine, Guizhou Hospital, Guiyang, 550002, China

    Guiqing Han

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  1. Xiaoming Guo
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  2. Helin Li
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  3. Zhiwen Zhang
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  4. Shouchun Li
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  5. Lizhi Zhang
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  6. Jiajing Zhang
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  7. Guiqing Han
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Correspondence to Xiaoming Guo.

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Guo, X., Li, H., Zhang, Z. et al. Hyperglycemia and Mortality Risk in Patients with Primary Intracerebral Hemorrhage: A Meta-Analysis. Mol Neurobiol 53, 2269–2275 (2016). https://doi.org/10.1007/s12035-015-9184-4

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  • DOI: https://doi.org/10.1007/s12035-015-9184-4

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