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CR1 in Alzheimer's Disease

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Abstract

The complement component receptor 1 gene (CR1), which encodes a type-I transmembrane glycoprotein, has recently been identified as one of the most important risk genes for late-onset Alzheimer's disease (LOAD). In this article, we reviewed the recent evidence concerning the role of CR1 in LOAD. First, we introduced the structure, localization and physiological function of CR1 in humans. Afterward, we summarized the relation of CR1 polymorphisms with LOAD risk. Finally, we discussed the possible impact of CR1 on the pathogenesis of AD including amyloid-β pathology, tauopathy, immune dysfunction and glial-mediated neuroinflammation. We hope that a more comprehensive understanding of the role that CR1 played in AD may lead to the development of novel therapeutics for the prevention and treatment of AD.

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Acknowledgments

This work was supported by the grants from the National Natural Science Foundation of China to L.T. (81171209, 81371406) and J.T.Y. (81000544), the grants from the Shandong Provincial Natural Science Foundation to L.T. (ZR2011HZ001) and J.T.Y. (ZR2010HQ004), the Medicine and Health Science Technology Development Project of Shandong Province to L.T. (2011WSA02018) and J.T.Y. (2011WSA02020) and the Innovation Project for Postgraduates of Jiangsu Province to T.J. (CXLX13_561).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China

    Xi-Chen Zhu, Jin-Tai Yu, Teng Jiang, Lei Cao & Lan Tan

  2. Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China

    Jin-Tai Yu, Ping Wang & Lan Tan

  3. Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China

    Jin-Tai Yu & Lan Tan

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  1. Xi-Chen Zhu
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Correspondence to Jin-Tai Yu, Ping Wang or Lan Tan.

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Zhu, XC., Yu, JT., Jiang, T. et al. CR1 in Alzheimer's Disease. Mol Neurobiol 51, 753–765 (2015). https://doi.org/10.1007/s12035-014-8723-8

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