Abstract
Adult neurogenesis is a unique form of plasticity found in the hippocampus, a brain region key to learning and memory formation. While many external stimuli are known to modulate the generation of new neurons in the hippocampus, little is known about the local circuitry mechanisms that regulate the process of adult neurogenesis. The neurogenic niche in the hippocampus is highly complex and consists of a heterogeneous population of cells including interneurons. Because interneurons are already highly integrated into the hippocampal circuitry, they are in a prime position to influence the proliferation, survival, and maturation of adult-generated cells in the dentate gyrus. Here, we review the current state of our understanding on the interplay between interneurons and adult hippocampal neurogenesis. We focus on activity- and signaling-dependent mechanisms, as well as research on human diseases that could provide better insight into how interneurons in general might add to our comprehension of the regulation and function of adult hippocampal neurogenesis.
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References
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Acknowledgements
The authors would like to acknowledge the past figures of Dr. Jessica Ables, Dr. Nathan DeCarolis, and Aparna Sankararaman for inspiring the figures in this review. This work was supported by grants to AJE from the National Institutes of Health and in particular grants from the National Institute on Drug Abuse (R01DA016765, R01DA016765-07S1, K02DA023555, R21DA023701) and grants from the National Alliance for Research on Schizophrenia and Depression and NASA. IM is supported by a postdoctoral fellowship on a Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research T32 Training Grant (T32DA 007290) from NIDA. The content is solely the responsibility of the authors and does not necessarily represent the official views of these granting organizations.
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Masiulis, I., Yun, S. & Eisch, A.J. The Interesting Interplay Between Interneurons and Adult Hippocampal Neurogenesis. Mol Neurobiol 44, 287–302 (2011). https://doi.org/10.1007/s12035-011-8207-z
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DOI: https://doi.org/10.1007/s12035-011-8207-z