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Friend or foe, the role of EGR-1 in cancer

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Abstract

Early growth response-1 (EGR-1), also termed NEFI-A and Krox-24, as a multi-domain protein is implicated in several vital physiological processes, including development, metabolism, cell growth and proliferation. Previous studies have implied that EGR-1 was producing in response to the tissue injury, immune response and fibrosis. Meanwhile, emerging studies stressed the pronounced correlation of EGR-1 and human cancers. Nevertheless, the intricate mechanisms of cancer-reduce EGR-1 alteration still poorly characterized. In the review, we evaluated the effects of EGR-1 in tumor cell proliferation, apoptosis, migration, invasion and tumor microenvironment, and then, we dwell on the intricate signaling pathways that EGR-1 involved in. The aberrantly expressed of EGR-1 in cancers are expected to provide a new cancer therapy strategy or a new marker for assessing treatment efficacy.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81572349, 81872080), Jiangsu Provincial Medical Talent (ZDRCA2016055), the Science and Technology Department of Jiangsu Province (BK20181148) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

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  1. Department of Pathology, Xuzhou Medical University, 209 Tong-shan Road, Xuzhou, 221004, Jiangsu, People’s Republic of China

    Tong-tong Li, Man-ru Liu & Dong-sheng Pei

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Li, Tt., Liu, Mr. & Pei, Ds. Friend or foe, the role of EGR-1 in cancer. Med Oncol 37, 7 (2020). https://doi.org/10.1007/s12032-019-1333-6

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