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Increased MMP-21 expression is associated with poor overall survival of patients with gastric cancer

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Abstract

Matrix metalloproteinase-21 (MMP-21) has been shown to enhance tumor invasion and metastasis ability in some solid tumors. In the present study, we investigated the expression of MMP-21 as well as its association with overall survival of gastric cancer patients. MMP-21 expression was investigated in 296 cases of gastric cancer by immunohistochemistry assay. Statistical analysis was utilized to evaluate the association of MMP-21 expression with overall survival of patients. MMP-21 expression was proved to be increased in gastric cancer compared with that in normal tissues (P < 0.05). It was also proved MMP-21 expression was associated with tumor invasion, metastasis and TNM stage (P < 0.001). MMP-21 expression was showed to be associated with overall survival of gastric cancer patients for patients with tumor of higher MMP-21 expression tend to have worse overall survival (P < 0.001). Multivariate analysis proved MMP-21 to be an independent prognostic factor for overall survival of gastric cancer patients (P < 0.001). These results suggested the potential role of MMP-21 in progression of human gastric cancer. It might also be a novel molecular marker to predict overall survival of patients with gastric cancer.

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Conflict of interest

We declared no conflict of interest.

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Authors and Affiliations

  1. Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710032, Shaanxi, China

    Tao Wu, Jianguo Lu, Qing Qiao, Guoqiang Bao, Nan Wang, Xianli He & Xilin Du

  2. Department of Gynaecology and Obstetrics, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China

    Yi Li

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  1. Tao Wu
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  2. Yi Li
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  3. Jianguo Lu
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  4. Qing Qiao
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  5. Guoqiang Bao
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  6. Nan Wang
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  7. Xianli He
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  8. Xilin Du
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Corresponding authors

Correspondence to Xianli He or Xilin Du.

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Tao Wu and Yi Li contributed equally to this study.

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Wu, T., Li, Y., Lu, J. et al. Increased MMP-21 expression is associated with poor overall survival of patients with gastric cancer. Med Oncol 30, 323 (2013). https://doi.org/10.1007/s12032-012-0323-8

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  • DOI: https://doi.org/10.1007/s12032-012-0323-8

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