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CCND1 G870A polymorphism and risk for head and neck cancer: a meta-analysis

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Abstract

CCND1 plays a critical role in cell cycle control and may contribute to head and neck cancer. We performed a meta-analysis of eleven case–control studies that examined the association between CCND1 G870A polymorphism and head and neck cancer risk. Overall, no significant association of this polymorphism with head and neck cancer was found (for AA vs. GG: OR = 0.96, 95% CI = 0.59–1.58, P < 0.01 for heterogeneity; for GA vs. GG: OR = 1.00, 95% CI = 0.74–1.35, P < 0.01 for heterogeneity; for the dominant model GA/AA vs. GG: OR = 0.98, 95% CI = 0.69–1.39, P < 0.01 for heterogeneity; for the recessive model AA vs. GG/GA: OR = 0.94, 95% CI = 0.66–1.33, P < 0.01 for heterogeneity). In subgroup analysis by ethnicity, we also did not find any significant association in European and Asians populations. All the results were not materially altered in any genetic model after the studies which did not fulfill Hardy–Weinberg equilibrium were excluded. In conclusion, our meta-analysis strongly suggested that the CCND1 G870A polymorphism is not associated with head and neck cancer risk.

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Acknowledgments

This study was supported by Nature Science Foundation of Jiangsu Province, China (No. BK2009346).

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Authors and Affiliations

  1. Dental Research Institute, School of Stomatology, Nanjing Medical University, 136 Hanzhong Rd., 210029, Nanjing, China

    Chunbo Tang, Jinhua Yu, Yunong Wu, Zhijun Zhu & Ning Chen

  2. Department of Epidemiology and Biostatistics, Nanjing Medical University, 210029, Nanjing, China

    Zhanwei Wang

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  1. Chunbo Tang
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  2. Zhanwei Wang
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  3. Jinhua Yu
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  4. Yunong Wu
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Correspondence to Chunbo Tang.

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Tang, C., Wang, Z., Yu, J. et al. CCND1 G870A polymorphism and risk for head and neck cancer: a meta-analysis. Med Oncol 28, 1319–1324 (2011). https://doi.org/10.1007/s12032-010-9547-7

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  • DOI: https://doi.org/10.1007/s12032-010-9547-7

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