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TGFB1 509 C/T polymorphism and colorectal cancer risk: a meta-analysis

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Abstract

Transforming growth factor β (TGF-β) is a cytokine. The TGF-β signaling pathway plays an important role in controlling cell proliferation and differentiation involved in colorectal carcinogenesis. In mammalian cells, TGFB1 is the most abundant subtype of TGF-β. The 509 C/T polymorphism in TGFB1 has been implicated in colorectal cancer risk. However, published data remain conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 994 cases and 2,335 controls from five published case–control studies was performed. Overall, significantly increased colorectal cancer risks were found for CC versus TT (OR = 1.62; 95% CI: 1.30–2.02; P heterogeneity = 0.118), TC + CC versus TT (OR = 1.30; 95% CI: 1.08–1.58; P heterogeneity = 0.259) and CC versus TC + TT (OR = 1.48; 95% CI: 1.26–1.75; P heterogeneity = 0.244). In the subgroup analysis by ethnicity, significantly increased risks were also found among Asians for CC versus TT (OR = 1.77; 95% CI: 1.40–2.24; P heterogeneity = 0.519), TC + CC versus TT (OR = 1.38; 95% CI: 1.13–1.68; P heterogeneity = 0.679) and CC versus TC + TT (OR = 1.58; 95% CI: 1.31–1.89; P heterogeneity = 0.340). However, no significant associations were found among Europeans for all genetic models. This meta-analysis showed that TGFB1 509 C allele is a risk factor for developing colorectal cancer in Asians.

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References

  1. Macdonald JS. Adjuvant therapy of colon cancer. CA Cancer J Clin. 1999;49:202–19.

    Article  CAS  PubMed  Google Scholar 

  2. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001;2:533–43.

    Article  CAS  PubMed  Google Scholar 

  3. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006;24:2137–50.

    Article  PubMed  Google Scholar 

  4. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108.

    Article  PubMed  Google Scholar 

  5. Sung JJY, Lau JY, Goh KL, Leung WK. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol. 2005;6:871–6.

    Article  PubMed  Google Scholar 

  6. Ulrich CM, et al. Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene environment interaction? Cancer Epidemiol Biomarkers Prev. 1999;8:659–68.

    CAS  PubMed  Google Scholar 

  7. Morimoto LM, et al. Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? Cancer Epidemiol Biomarkers Prev. 2002;11:1012–8.

    PubMed  Google Scholar 

  8. Maltese P, et al. VEGF gene polymorphisms and susceptibility to colorectal cancer disease in Italian population. Int J Colorectal Dis. 2009;24:165–70.

    Article  PubMed  Google Scholar 

  9. Liang X, et al. Association between HRE-2 gene polymorphism at codon 655 and genetic susceptibility of colorectal cancer. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:302–5.

    CAS  PubMed  Google Scholar 

  10. Tashakori M, Noorinayer B, Khatami F, Zali MR. Role of tumor necrosis factor gene polymorphism (-308 and-238) in colorectal cancer susceptibility. Ann Oncol. 2008;19:I30–1.

    Google Scholar 

  11. Chae YS, et al. Association of vascular endothelial growth factor gene polymorphisms with susceptibility and clinicopathologic characteristics of colorectal cancer. J Korean Med Sci. 2008;23:421–7.

    Article  CAS  PubMed  Google Scholar 

  12. Tashakori M, Noorinayer B, Tashakori M. Association of single nucleotide polymorphism in the promoter of TNF-alpha gene (-308 G > A) with susceptibility to colorectal cancer among Iranian population. Ann Oncol. 2008;19:82.

    Google Scholar 

  13. Campa D, et al. A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer. Mutat Res-Fund Mol M. 2008;645:56–60.

    Article  CAS  Google Scholar 

  14. Frances CP, et al. Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility. J Gastroenterol Hepatol. 2007;22:2298–302.

    Article  CAS  PubMed  Google Scholar 

  15. Yaylim-Eraltan I, et al. Investigation of the VDR gene polymorphisms association with susceptibility to colorectal cancer. Cell Biochem Funct. 2007;25:731–7.

    Article  CAS  PubMed  Google Scholar 

  16. Skoglund J, et al. Investigation of the TGFBR1 gene and its role as a colorectal cancer and adenoma susceptibility gene. Proc Annu Meet Am Assoc Cancer Res. 2006;47:873.

    Google Scholar 

  17. Jin MJ, et al. The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population. Cancer Genet Cytogenet. 2005;163:38–43.

    Article  CAS  PubMed  Google Scholar 

  18. Bermano G, et al. Glutathione peroxidase 4 gene polymorphism and susceptibility to colorectal cancer. J Nutr. 2004;134:3526S.

    Google Scholar 

  19. Hsieh YY, et al. Polymorphism for transforming growth factor beta 1–509 (TGF-B1–509): association with endometriosis. Biochem Genet. 2005;43:203–10.

    Article  CAS  PubMed  Google Scholar 

  20. Chung SJ, Kim JS, Jung HC, Song IS. Transforming growth factor-β1 509T reduces risk of colorectal cancer, but not adenoma in Koreans. Cancer Sci. 2007;98:401–4.

    Article  CAS  PubMed  Google Scholar 

  21. Watanabe Y, et al. A catalog of 106 single-nucleotide polymorphisms (SNPs) and other types of variations in genes for transforming growth factor-β1 (TGF-β1) and its signaling pathway. J Hum Genet. 2002;47:478–83.

    Article  CAS  PubMed  Google Scholar 

  22. Crivello A, et al. Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma. Ann N Y Acad Sci. 2006;1089:98–103.

    Article  CAS  PubMed  Google Scholar 

  23. Shu XO, et al. Genetic polymorphisms in the TGF-β1 gene in breast cancer survival: a report from the Shanghai breast cancer study. Cancer Res. 2004;64:836–9.

    Article  CAS  PubMed  Google Scholar 

  24. Park KH, et al. Single nucleotide polymorphisms of the TGFB1 gene and lung cancer risk in a Korean population. Cancer Genet Cytogenet. 2006;169:39–44.

    Article  CAS  PubMed  Google Scholar 

  25. Gewaltig J, Mangasser-Stephan K, Gartung C, Biesterfeld S, Gressner AM. Association of polymorphisms of the transforming growth factor-β1 gene with the rate of progression of HCV-induced liver fibrosis. Clin Chim Acta. 2002;316:83–94.

    Article  CAS  PubMed  Google Scholar 

  26. Awad MR, et al. Genotypic variation in the transforming growth factor-beta 1 gene—association with transforming growth factor-pi production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation. 1998;66:1014–20.

    Article  CAS  PubMed  Google Scholar 

  27. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  CAS  PubMed  Google Scholar 

  28. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    CAS  PubMed  Google Scholar 

  29. Amirghofran Z, Jalali SA, Ghaderi A, Hosseini SV. Genetic polymorphism in the transforming growth factor β1 gene (-509 C/T and-800 G/A) and colorectal cancer. Cancer Genet Cytogenet. 2009;190:21–5.

    Article  CAS  PubMed  Google Scholar 

  30. Wu GY, et al. Association between EGF, TGF-β1, VEGF gene polymorphism and colorectal cancer. World J Surg. 2009;33:124–9.

    Article  PubMed  Google Scholar 

  31. Zhang YJ, et al. Genetic polymorphisms of transforming growth factor-β1 and its receptors and colorectal cancer susceptibility: a population-based case–control study in China. Cancer Lett. 2009;275:102–8.

    Article  CAS  PubMed  Google Scholar 

  32. Wu HM, et al. Transforming growth factor-beta 1 gene C-509T polymorphism and genetic susceptibility to colorectal cancer. Shi Jie Hua Ren Xiao Hua Za Zhi. 2008;16:4020–3.

    CAS  Google Scholar 

  33. Walther A, et al. Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer. 2009;9:489–99.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 200433, Shanghai, People’s Republic of China

    Fang Fang, Long Yu & Lei Yao

  2. Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Sciences, Fudan University, 200433, Shanghai, People’s Republic of China

    Yang Zhong & Lei Yao

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  1. Fang Fang
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  2. Long Yu
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Correspondence to Lei Yao.

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Fang, F., Yu, L., Zhong, Y. et al. TGFB1 509 C/T polymorphism and colorectal cancer risk: a meta-analysis. Med Oncol 27, 1324–1328 (2010). https://doi.org/10.1007/s12032-009-9383-9

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  • DOI: https://doi.org/10.1007/s12032-009-9383-9

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