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Association Between EGF, TGF-β1, VEGF Gene Polymorphism and Colorectal Cancer

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Abstract

Introduction

Up to the present, EGF 61 A/G, TGF-β1 −509 T/C, and VEGF 936 T/C gene polymorphisms have been analyzed in other cancer entities than colorectal cancer. We have now investigated the frequency of these gene polymorphisms among colorectal cancer patients.

Material and methods

A total of 157 colorectal cancer patients and 117 cancer-free healthy people were recruited at the Surgical Department of the Universitätsklinikum Mannheim. All patients and healthy people are Caucasians. Genomic DNA was isolated from peripheral blood, and gene polymorphisms were analyzed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP).

Results

The distribution of EGF 61 G/G homozygotes among colorectal cancer patients was more frequent than that in the control group (33.1% versus 11.1%; Odds Ratio [OR] = 3.962; 95% Confidence Interval [CI] = 2.036–7.708). The frequency of the “G” allele in the colorectal cancer patient group was also higher than that in the control group (51.3% versus 33.3%; OR = 2.105; 95% CI = 1.482–2.988). No difference could be found for the TGF-β1 and VEGF genotypes among colorectal cancer patients and healthy controls.

Conclusions

The EGF 61 G/G genotype and the G allele are significantly related to colorectal cancer. The TGF-β1 −509 T/C and VEGF 936 T/C gene polymorphisms are not related to colorectal cancer.

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Acknowledgments

This study was surported by the Paul-Blümel Stiftung, Hannover, Germany.

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Authors and Affiliations

  1. Department of General Surgery, Zhongshan Hospital, Xiamen University, Xiamen, People’s Republic of China

    Guo-yang Wu

  2. Surgical Clinic, University Hospital Mannheim, 68167, Mannheim, Germany

    Till Hasenberg, Richard Magdeburg, Roderich Bönninghoff, Jörg W. Sturm & Michael Keese

Authors
  1. Guo-yang Wu
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  2. Till Hasenberg
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  3. Richard Magdeburg
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  4. Roderich Bönninghoff
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  5. Jörg W. Sturm
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  6. Michael Keese
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Corresponding author

Correspondence to Michael Keese.

Additional information

Guo-yang Wu and Till Hasenberg contributed equally to this work.

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Wu, Gy., Hasenberg, T., Magdeburg, R. et al. Association Between EGF, TGF-β1, VEGF Gene Polymorphism and Colorectal Cancer. World J Surg 33, 124–129 (2009). https://doi.org/10.1007/s00268-008-9784-5

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  • DOI: https://doi.org/10.1007/s00268-008-9784-5

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