Skip to main content

Advertisement

SpringerLink
Log in

Association Between Stroke and Parkinson’s Disease: a Meta-analysis

  • Published:
Journal of Molecular Neuroscience Aims and scope Submit manuscript

Abstract

Parkinson’s disease (PD) and stroke are both associated with aging, but the relationship between these two disorders remains unclear. Recent evidence has shown that they frequently co-occur and are influenced by each another, although some studies have found inconsistent results. We performed this meta-analysis of patients with PD on stroke risk to clarify the relationship between these two disorders on the basis of the studies published from 1975 to July 2019 in the PubMed, EMBASE, and Cochrane Library databases. In total, 13 case–control studies met the inclusion criteria for meta-analysis. The pooled odds ratio (OR) for PD in relation to the stroke risk was 1.72 (95% confidence interval (CI) 1.19–2.49). The OR for the presence of cerebral infarct among PD in the four studies was 1.35 (95% CI 1.04–1.74). Moreover, the OR for the presence of stroke pathology among PD in the four postmortem studies was 1.86 (95% CI 1.17–2.98). In conclusion, our meta-analysis suggests that there is an association between stroke and PD. Sensitivity analysis was used to test the robustness of our results through the sequential removal of each one study at time, in order to investigate if a single study was driving the study results. These results indicate that PD and stroke may have a common pathogenesis and may share preventive treatment measures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Androutsopoulos VP, Kanavouras K, Tsatsakis AM (2011) Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases. Toxicol Appl Pharmacol 256(3):418–424

    CAS  PubMed  Google Scholar 

  • Baltazar MT, Dinis-Oliveira RJ, de Lourdes Bastos M, Tsatsakis AM, Duarte JA, Carvalho F (2014) Pesticides exposure as etiological factors of Parkinson’s disease and other neurodegenerative diseases-a mechanistic approach. Toxicol Lett 230(2):85–103

    CAS  PubMed  Google Scholar 

  • Becker C, Jick SS, Meier CR (2010) Risk of stroke in patients with idiopathic Parkinson disease. Parkinsonism Relat Disord 16(1):31–35

    PubMed  Google Scholar 

  • Beilina A, Cookson MR (2016) Genes associated with Parkinson’s disease: regulation of autophagy and beyond. J Neurochem 139(Suppl 1):91–107

    CAS  PubMed  Google Scholar 

  • Chaudhuri KR, Healy DG, Schapira AH, National Institute for Clinical, E (2006) Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol 5(3):235–245

    PubMed  Google Scholar 

  • Collier TJ, Kanaan NM, Kordower JH (2011) Ageing as a primary risk factor for Parkinson’s disease: evidence from studies of non-human primates. Nature reviews. Neuroscience 12(6):359–366

    CAS  PubMed  Google Scholar 

  • Dardiotis E, Xiromerisiou G, Hadjichristodoulou C, Tsatsakis AM, Wilks MF, Hadjigeorgiou GM (2013) The interplay between environmental and genetic factors in Parkinson’s disease susceptibility: the evidence for pesticides. Toxicology 307:17–23

    CAS  PubMed  Google Scholar 

  • de Oliveira RM, Sarkander J, Kazantsev AG, Outeiro TF (2012) SIRT2 as a therapeutic target for age-related disorders. Front Pharmacol 3:82

    PubMed  PubMed Central  Google Scholar 

  • Dexter DT, Jenner P (2013) Parkinson disease: from pathology to molecular disease mechanisms. Free Radic Biol Med 62:132–144

    CAS  PubMed  Google Scholar 

  • Eigenbrodt ML, Rose KM, Couper DJ, Arnett DK, Smith R, Jones D (2000) Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke 31(10):2307–2313

    CAS  PubMed  Google Scholar 

  • Fernandez B, Ferrer I, Gil F, Hilfiker S (2017) Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients. Toxicol Rep 4:188–193

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ghebremedhin E, Rosenberger A, Rub U, Vuksic M, Berhe T, Bickeboller H, de Vos RA, Thal DR, Deller T (2010) Inverse relationship between cerebrovascular lesions and severity of lewy body pathology in patients with lewy body diseases. J Neuropathol Exp Neurol 69(5):442–448

    PubMed  Google Scholar 

  • Gill D, Monori G, Tzoulaki I, Dehghan A (2018) Iron status and risk of stroke. Stroke 49(12):2815–2821

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hirsch EC, Vyas S, Hunot S (2012) Neuroinflammation in Parkinson’s disease. Parkinsonism Relat Disord 18(Suppl 1):S210–S212

    PubMed  Google Scholar 

  • Huang YF, Yeh CC, Chou YC, Hu CJ, Cherng YG, Shih CC, Chen TL, Liao CC (2019) Stroke in Parkinson’s disease. QJM 112(4):269–274

    PubMed  Google Scholar 

  • Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55(3):181–184

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jankovic J, Stacy M (2007) Medical management of levodopa-associated motor complications in patients with Parkinson’s disease. CNS Drugs 21(8):677–692

    CAS  PubMed  Google Scholar 

  • Jellinger KA (2003a) Prevalence of cerebrovascular lesions in Parkinson’s disease. A postmortem study. Acta Neuropathol 105(5):415–419

    PubMed  Google Scholar 

  • Jellinger KA (2003b) Prevalence of stroke in Parkinson’s disease. Mov Disord 18(6):723–724

    PubMed  Google Scholar 

  • Jellinger KA (2003c) Prevalence of vascular lesions in dementia with Lewy bodies. A postmortem study. J Neural Transmiss (Vienna, Austria : 1996) 110(7):771–778

    CAS  Google Scholar 

  • Kim T, Mehta SL, Kaimal B, Lyons K, Dempsey RJ, Vemuganti R (2016) Poststroke induction of alpha-synuclein mediates ischemic brain damage. J Neurosci 36(26):7055–7065

    CAS  PubMed  PubMed Central  Google Scholar 

  • Levine RL, Jones JC, Bee N (1992) Stroke and Parkinson’s disease. Stroke 23(6):839–842

    CAS  PubMed  Google Scholar 

  • Li Q, Wang C, Tang H, Chen S, Ma J (2018) Stroke and coronary artery disease are associated with Parkinson’s disease. The Canadian journal of neurological sciences. J Can Sci Neurol 45(5):559–565

    Google Scholar 

  • Lynch-Day MA, Mao K, Wang K, Zhao M, Klionsky DJ (2012) The role of autophagy in Parkinson’s disease. Cold Spring Harb Perspect Med 2(4):a009357

    PubMed  PubMed Central  Google Scholar 

  • Marttila RJ, Rinne UK (1976) Arteriosclerosis, heredity, and some previous infections in the etiology of Parkinson’s disease. A case-control study. Clin Neurol Neurosurg 79(1):46–56

    CAS  PubMed  Google Scholar 

  • Mastaglia FL, Johnsen RD, Kakulas BA (2002) Prevalence of stroke in Parkinson’s disease: a postmortem study. Mov Disord 17(4):772–774

    PubMed  Google Scholar 

  • McCann SJ, LeCouteur DG, Green AC, Brayne C, Johnson AG, Chan D, McManus ME, Pond SM (1998) The epidemiology of Parkinson’s disease in an Australian population. Neuroepidemiology 17(6):310–317

    CAS  PubMed  Google Scholar 

  • Nataraj A, Rajput AH (2005) Parkinson’s disease, stroke, and related epidemiology. Mov Disord 20(11):1476–1480

    PubMed  Google Scholar 

  • Novak V, Novak P, Spies JM, Low PA (1998) Autoregulation of cerebral blood flow in orthostatic hypotension. Stroke 29(1):104–111

    CAS  PubMed  Google Scholar 

  • Patel M, Coutinho C, Emsley HC (2011) Prevalence of radiological and clinical cerebrovascular disease in idiopathic Parkinson’s disease. Clin Neurol Neurosurg 113(10):830–834

    CAS  PubMed  Google Scholar 

  • Pilotto A, Turrone R, Liepelt-Scarfone I, Bianchi M, Poli L, Borroni B, Alberici A, Premi E, Formenti A, Bigni B, Cosseddu M, Cottini E, Berg D, Padovani A (2016) Vascular risk factors and cognition in Parkinson’s disease. J Alzheimers Dis 51(2):563–570

    CAS  PubMed  Google Scholar 

  • Pringsheim T, Jette N, Frolkis A, Steeves TD (2014) The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 29(13):1583–1590

    PubMed  Google Scholar 

  • Rose KM, Tyroler HA, Nardo CJ, Arnett DK, Light KC, Rosamond W, Sharrett AR, Szklo M (2000) Orthostatic hypotension and the incidence of coronary heart disease: the Atherosclerosis Risk in Communities study. Am J Hypertens 13(6 Pt 1):571–578

    CAS  PubMed  Google Scholar 

  • Satoh A, Imai S (2014) Systemic regulation of mammalian ageing and longevity by brain sirtuins. Nat Commun 5:4211

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schapira AH, Jenner P (2011) Etiology and pathogenesis of Parkinson’s disease. Mov Disord 26(6):1049–1055

    Google Scholar 

  • Scigliano G, Musicco M, Soliveri P, Piccolo I, Ronchetti G, Girotti F (2006) Reduced risk factors for vascular disorders in Parkinson disease patients: a case-control study. Stroke 37(5):1184–1188

    PubMed  Google Scholar 

  • Skeie GO, Muller B, Haugarvoll K, Larsen JP, Tysnes OB (2013) Parkinson disease: associated disorders in the Norwegian population based incident ParkWest study. Parkinsonism Relat Disord 19(1):53–55

    CAS  PubMed  Google Scholar 

  • Struck LK, Rodnitzky RL, Dobson JK (1990) Stroke and its modification in Parkinson’s disease. Stroke 21(10):1395–1399

    CAS  PubMed  Google Scholar 

  • Tajbakhsh A, Rezaee M, Rivandi M, Forouzanfar F, Afzaljavan F, Pasdar A (2017) Paraoxonase 1 (PON1) and stroke; the dilemma of genetic variation. Clin Biochem 50(18):1298–1305

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to acknowledge the investigators for their helpful comments regarding this paper.

Funding

This work was supported by grants from Natural Science Foundation of China (81971192).

Author information

Authors and Affiliations

  1. Department of Neurology, Affiliated Hospital of Qingdao University, No. 16 Jiangsu road, Qingdao, 266003, Shandong Province, People’s Republic of China

    Yumei Liu, Yingying Zhang & Anmu Xie

  2. Medical Record Department, Affiliated Hospital of Qingdao University, Qingdao, China

    Li Xue

Authors
  1. Yumei Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li Xue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yingying Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anmu Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yingying Zhang or Anmu Xie.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflicts of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, Y., Xue, L., Zhang, Y. et al. Association Between Stroke and Parkinson’s Disease: a Meta-analysis. J Mol Neurosci 70, 1169–1176 (2020). https://doi.org/10.1007/s12031-020-01524-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12031-020-01524-9

Keywords

Search

Navigation