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Association Between SLC1A1 Gene and Early-Onset OCD in the Han Chinese Population: A Case–Control Study

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Abstract

Obsessive–compulsive disorder (OCD) is a common and severe mental illness, and its etiology still remains unknown. The glutamate transporter gene solute carrier family 1, member 1 was previously tested as a promising candidate for OCD by several research groups. However, subsequent studies were not consistent. OCD is a heterogeneous disease. Early-onset OCD is a demographically and clinically distinct subtype of OCD and may be a more homogeneous subtype. Gender-matched 244 early-onset OCD patients, 244 late-onset OCD patients, and 244 healthy controls were genotyped with four SNPs (rs10491734, rs2228622, rs301430, and rs301443) through TaqMan SNP genotyping assays. There were statistical differences in allele and genotype frequencies of rs10491734 in early-onset OCD patients compared to late-onset OCD or control subjects. The haplotype analysis showed that the four-locus haplotype (A-A-C-C and A-G-C-C) were associated with early onset obsessive–compulsive disorder after Bonferroni correction. The present study provided suggestive evidence that the rs10491734 was significantly associated with early-onset OCD in the Han Chinese population. However, these findings need further replication.

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Acknowledgments

The authors thank Shanghai Mental Health Center and all the patients and volunteers who made this research possible. This study was supported by grants from National High Technology Research and Development Program of China (863 program, no. 2007AAO2Z420 and no. 2008AA02Z412); Doctorate Foundation of Shanghai Jiao Tong University School of Medicine (BXJ201047); National Natural Science Foundation of China (81171280).

Conflict of Interest

The manuscript is new and original and it has never been published either electronically or in print. All of the authors have no conflict of interest affecting this study.

Role of the Funding Source

This study was supported by grants from the National High Technology Research and Development Program of China (863 program, no. 2007aao2z420 and no. 2008AA02Z412); Doctorate Foundation of Shanghai Jiao Tong University School of Medicine (BXJ201047); and the National Natural Science Foundation of China (81171280).

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Authors and Affiliations

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030, Shanghai, China

    Haisu Wu, Xuemei Wang, Zeping Xiao, Shunying Yu, Liping Zhu, Dongxiang Wang, Kaida Jiang, Zhen Wang, Tianhong Zhang & Drew Fralick

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  1. Haisu Wu
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Correspondence to Zeping Xiao.

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Wu, H., Wang, X., Xiao, Z. et al. Association Between SLC1A1 Gene and Early-Onset OCD in the Han Chinese Population: A Case–Control Study. J Mol Neurosci 50, 353–359 (2013). https://doi.org/10.1007/s12031-013-9995-6

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  • DOI: https://doi.org/10.1007/s12031-013-9995-6

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