Abstract
Bioferrofluids obtained from carbon coated iron nanoparticles are promising candidates for magnetic drug delivery. The carbon cages render the particles biocompatible, and provide a good support for drug adsorption. We propose a method in which gold plated permanent magnets are implanted directly in the affected organ, close to the tumour, by endoscopic techniques. The bioferrofluid charged with the chemotherapeutic agent is injected and the particles attracted to the magnet, then desorption of the drug takes place at the tumoral region. This method seems to be more promising, costless and effective than that based on the application of external magnetic fields. Preliminary results of drug adsorption and a preclinical experimental animal model are described.
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Fernández-Pacheco, R., Ibarra, M.R., Valdivia, J.G. et al. Carbon coated magnetic nanoparticles for local drug delivery using magnetic implants. Nanobiotechnol 1, 300–303 (2005). https://doi.org/10.1007/s12030-005-0051-7
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DOI: https://doi.org/10.1007/s12030-005-0051-7