Skip to main content
Log in

Associated Factors of Survival Rate and Screening for Colorectal Cancer in Iran: a Systematic Review

  • Review Article
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Purpose

Colorectal cancer (CRC) is one of the most important cancers, which has various patterns in the world. The aim of this study was to determine the factor associated to survival and looking for screening in Iran.

Methods

A literature search was conducted using PubMed, Web of Science, Scopus, SID, and Magiran on June 30, 2018. Studies that performed survival analysis and the barrier of screening for colorectal cancer were included in this review.

Results

Fifty-three articles for survival and 11 for screening were included and examined. The important factors of survival are the age, cancer stage, tumor grade, ethnicity, marital status, family history of cancer, smoking, metastasis, and obesity. For barrier of screening, the cost, shame, fear of diagnosis the cancer, absence of clinical symptoms, and time limit were determined.

Conclusion

Remarkably, knowledge, attitude, and behaviors about CRC screening in Iran are very moderate to poor. According to diversity of survival rates and low tendency to screening, we need to further and deepen studies of barrier and facilitators of screening.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ferlay J, Colombet M, Soerjomataram I. Global and regional estimates of the incidence and mortality for 38 cancers: GLOBOCAN 2018. Lyon: International Agency for Research on Cancer. World Health Organization; 2018.

    Google Scholar 

  2. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9(1):88.

    PubMed  PubMed Central  Google Scholar 

  3. Johnson CM, Wei C, Ensor JE, Smolenski DJ, Amos CI, Levin B, et al. Meta-analyses of colorectal cancer risk factors. Cancer Causes Control. 2013;24(6):1207–22.

    PubMed  PubMed Central  Google Scholar 

  4. Forbes LJ, Warburton F, Richards M, Ramirez A. Risk factors for delay in symptomatic presentation: a survey of cancer patients. Br J Cancer. 2014;111(3):581–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Lyratzopoulos G, Abel G, Brown C, Rous B, Vernon S, Roland M, et al. Socio-demographic inequalities in stage of cancer diagnosis: evidence from patients with female breast, lung, colon, rectal, prostate, renal, bladder, melanoma, ovarian and endometrial cancer. Ann Oncol. 2012;24(3):843–50.

    PubMed  PubMed Central  Google Scholar 

  6. Rachet B, Ellis L, Maringe C, Chu T, Nur U, Quaresma M, et al. Socioeconomic inequalities in cancer survival in England after the NHS cancer plan. Br J Cancer. 2010;103(4):446–53.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Ramirez A, Westcombe A, Burgess C, Sutton S, Littlejohns P, Richards M. Factors predicting delayed presentation of symptomatic breast cancer: a systematic review. Lancet. 1999;353(9159):1127–31.

    CAS  PubMed  Google Scholar 

  8. Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin. 2008;58(3):130–60.

    PubMed  Google Scholar 

  9. Gany FM, Herrera AP, Avallone M, Changrani J. Attitudes, knowledge, and health-seeking behaviors of five immigrant minority communities in the prevention and screening of cancer: a focus group approach. Ethn Health. 2006;11(1):19–39.

    PubMed  Google Scholar 

  10. Maree JE, Wright SC. How would early detection be possible? An enquiry into cancer related knowledge, understanding and health seeking behaviour of urban black women in Tshwane, South Africa. Eur J Oncol Nurs. 2010;14(3):190–6.

    PubMed  Google Scholar 

  11. Faivre J, Bossard N, Jooste V. Trends in net survival from colon cancer in six European Latin countries: results from the SUDCAN population-based study. Eur J Cancer Prev : the official journal of the European Cancer Prevention Organisation (ECP). 2017;26 Trends in cancer net survival in six European Latin Countries: the SUDCAN study:S40–s47. https://doi.org/10.1097/cej.0000000000000293.

    Article  Google Scholar 

  12. Mengual-Ballester M, Pellicer-Franco E, Valero-Navarro G, Soria-Aledo V, García-Marín JA, Aguayo-Albasini JL. Increased survival and decreased recurrence in colorectal cancer patients diagnosed in a screening programme. Cancer Epidemiol. 2016;43:70–5.

    PubMed  Google Scholar 

  13. Wells G SB, O’Connell D, Peterson j, Welch V, Losos M (2000) The Newcastle–Ottawa Scale (NOS) for assessing the quality of non-randomized studies in meta-analysis.

  14. Baghianimoghadam M, FATTAHI AM, Akhondi M, Mortazavizadeh M, Fallahzadeh H. Intention of colorectal cancer patients’ first degree relatives to screening based on planned behavior theory. TOLOO-E-BEHDASHT. 2012;10:13–22.

    Google Scholar 

  15. Baghianimoghadam MH, Ardakani MF, Akhoundi M, Mortazavizadeh MR, Fallahzadeh MH, Baghianimoghadam B. Effect of education on knowledge, attitude and behavioral intention in family relative with colorectal cancer patients based on theory of planned behavior. Asian Pac J Cancer Prev. 2012;13(12):5995–8.

    PubMed  Google Scholar 

  16. Bidouei F, Abdolhosseini S, Jafarzadeh N, Izanloo A, Ghaffarzadehgan K, Abdolhosseini A, et al. Knowledge and perception toward colorectal cancer screening in east of Iran. Int J Health Policy Manag. 2014;3(1):11–5.

    PubMed  PubMed Central  Google Scholar 

  17. Salimzadeh H, Bishehsari F, Delavari A, Barzin G, Amani M, Majidi A, et al. Cancer risk awareness and screening uptake in individuals at higher risk for colon cancer: a cross-sectional study. BMJ Open. 2016;6(12):e013833.

    PubMed  PubMed Central  Google Scholar 

  18. Salimzadeh H, Bishehsari F, Sauvaget C, Amani M, Hamzehloo G, Nikfarjam A, et al. Feasibility of colon cancer screening by fecal immunochemical test in Iran. Arch Iran Med (AIM). 2017;20(12):726–33.

    Google Scholar 

  19. Salimzadeh H, Delavari A, Montazeri A, Mirzazadeh A. Knowledge and practice of iranians toward colorectal cancer, and barriers to screening. Int J Prev Med. 2012;3(1):29.

    PubMed  PubMed Central  Google Scholar 

  20. Salimzadeh H, Eftekhar H, Majdzadeh R, Montazeri A, Shojaeizadeh D, Delavari A. More than half of senior residents in Tehran have never heard about colorectal cancer screening. Asian Pac J Cancer Prev. 2011;12(11):2851–6.

    PubMed  Google Scholar 

  21. Taheri-Kharameh Z, Noorizadeh F, Sangy S, Zamanian H, Shouri-Bidgoli AR, Oveisi H. Factors associated with adherence to colorectal cancer screening among moderate risk individuals in Iran. Asian Pac J Cancer Prev. 2015;16(18):8371–5.

    PubMed  Google Scholar 

  22. HA AS-BZTK, Sharififard F, Arani MS, Gol AHA, Sulmati MZ, Mirzaei S, et al. Evaluation of knowledge, attitude and practice of people over 50 years old toward colorectal cancer screening, based on health belief model. Qom Univ Med Sci J. 2015;9(1):59–65.

    Google Scholar 

  23. Moattari M, SFM RM, Zare N, Sakina G. The effect of education based on health belief model on the knowledge and participation of at risk individuals in colorectal cancer screening. Res Med. 2008;33(1):47–54.

    Google Scholar 

  24. Roozitalab M, GS MM, Mahdi SF, Zare N. The effect of health beliefs on university administrative staff participation in colorectal cancer screening programs-1383. Digestive journal. 2004;13(1):19–24.

    Google Scholar 

  25. Moghimi DB, Safaei A, Zali MR. (2008)Survival rates and prognostic factors in colorectal cancer patients. Asian Pac J Cancer Prev. 2016;17(7):3575–81.

    Google Scholar 

  26. Asghari Jafarabadi M, Hajizadeh E, Kazemnejad A, Fatemi S. Site-specific evaluation of prognostic factors on survival in Iranian colorectal cancer patients: a competing risks survival analysis. Asian Pac J Cancer Prev. 2009;10(5):815–21.

    CAS  PubMed  Google Scholar 

  27. Esna-ashari F, Sohrabi MR, Abadi AR, Mehrabian AA, Kolahi AA, Yavari P, et al. Colorectal cancer prevalence according to survival data in Iran in 2007. Pejouhesh dar Pezeshki (Research in Medicine). 2008;32(3):221–5.

    Google Scholar 

  28. Moghimi-Dehkordi B, Safaee A, Zali MR. Comparison of colorectal and gastric cancer: survival and prognostic factors. Saudi J Gastroenterol: official journal of the Saudi Gastroenterology Association. 2009;15(1):18.

    Google Scholar 

  29. Moradi A, Khayamzadeh M, Guya MM, Mirzaei HR, Salmanian R, Rakhsha A, et al. Survival of colorectal cancer in Iran. Asian Pac J Cancer Prev. 2009;10(4):583–6.

    PubMed  Google Scholar 

  30. Safaee AM-DB, Fatemi SR, Ghiasi S, Zali MR. Pathology and prognosis of colorectal cancer. Iran J Cancer Prev. 2009;2(3):137–41.

    Google Scholar 

  31. Asghari Jafarabadi M, Hajizadeh E, Kazemnejad A, Fatemi S. Comparison the role of BMI, pathologic stage and hereditary related factors on survival between colon and rectal cancers: frailty competing risks model. Iran J Epidemiol. 2010;6(3):35–49.

    Google Scholar 

  32. Safaee A, Moghimi-Dehkordi B, Fatemi S, Ghiasi S, Nemati-Malek F, Zali M. Characteristics of colorectal mucinous adenocarcinoma in Iran. Asian Pac J Cancer Prev. 2010;11(5):1373–5.

    PubMed  Google Scholar 

  33. Akhoond MR, Kazemnejad A, Hajizadeh E, GAnbary Motlagh A, Zali MR. Comparison of influential factors affecting survival of patients with colon and rectum cancer using competing risks model. Koomesh. 2011;12(2):119–28.

    Google Scholar 

  34. Ghabeljoo M, Jafarabadi MA, Mohammadi SM, Hajizadeh E, Kazemnejad A, Fatemi SR. Patterns of survival for anatomical sites of colorectal cancer with shift to advanced lesions in Iran. Asian Pac J Cancer Prev. 2011;12(5):1225–31.

    PubMed  Google Scholar 

  35. Gohari MR, Biglarian A, Bakhshi E, Pourhoseingholi MA. Use of an artificial neural network to determine prognostic factors in colorectal cancer patients. Asian Pac J Cancer Prev. 2011;12(6):1469–72.

    PubMed  Google Scholar 

  36. Mehrabani D, Almasi-Hashiani A, Moshfeghi K, Khedmati E. Survival rate and its predictors in colorectal cancer patients, Southern Iran. Middle-East J Sci Res. 2012;12(8):1072–7.

    Google Scholar 

  37. Aryaie M, Roshandel G, Semnani S, Asadi-Lari M, Aarabi M, Vakili MA, Kazemnejhad V, Sedaghat SM, Solaymani-Dodaran M (2013) Predictors of colorectal cancer survival in Golestan, Iran: a population-based study. Epidemiology and health 35.

  38. Heidarnia MA, Monfared ED, Akbari ME, Yavari P, Amanpour F, Mohseni M. Social determinants of health and 5-year survival of colorectal cancer. Asian Pac J Cancer Prev. 2013;14(9):5111–6.

    PubMed  Google Scholar 

  39. Akhavan A, Binesh F, Soltani A. Survival of rectal cancer in Yazd, Iran. Asian Pacific J Cancer Prev: APJCP. 2014;15(12):4857–60.

    Google Scholar 

  40. Nosrati A, Naghshvar F, Torabizadeh Z, Salehi F. Correlation of colorectal cancer stem cell marker CD24 expression with clinicopathologic features and survival of patients with colorectal cancer. Govaresh. 2014;19(2):86–94.

    Google Scholar 

  41. Ahmadi A, Mobasheri M, Hashemi Nazari SS. Survival time and relative risk of death in patients with colorectal cancer in an Iranian population: a cohort study. J Mazandaran Univ Med Sci. 2014;24(111):2–8.

    Google Scholar 

  42. Fatemi SR, Pourhoseingholi MA, Asadi F, Vahedi M, Pasha S, Alizadeh L, et al. Recurrence and five-year survival in colorectal cancer patients after surgery. Iran J Cancer Prev. 2015;8(4).

  43. Semnani S, Noorafkan Z, Aryaie M, Sedaghat SM, Moghaddami A, Kazemnejhad V, et al. Determinants of healthcare utilisation and predictors of outcome in colorectal cancer patients from northern Iran. Eur J Cancer Care. 2016;25(2):318–23.

    CAS  Google Scholar 

  44. Zargar A, Miroliaee A, Gooraji SA, Hajaghamohammadi A. Determination of effective factors on survival of GI cancers: results of five years follow up in Iranian population. Global J Health Sci. 2016;8(6):256.

    Google Scholar 

  45. Mehrkhani F, Nasiri S, Donboli K, Meysamie A, Hedayat A. Prognostic factors in survival of colorectal cancer patients after surgery. Color Dis. 2009;11(2):157–61.

    CAS  Google Scholar 

  46. Dianatinasab M, Ghaem H, Rezaianzadeh A, Hosseini SV, Khazraei H. Colorectal Cancer mortality in shiraz, Iran. Asian Pac J Cancer Prev. 2016;17(8):4101–5.

    PubMed  Google Scholar 

  47. Ghahremani R, Yavari P, Khodakarim S, Etemad K, Khosravi A. The estimated survival rates for colorectal cancer and related factors in Iran from 1384 to 1388 using the Aalen’s additive risk model. Iran J Epidemiol. 2016;11(4):20–9.

    Google Scholar 

  48. Saki Malehi A, Hajizadeh E, Fatemi R. Evaluation of prognostic variables for classifying the survival in colorectal patients using the decision tree. Iran J Epidemiol. 2012;8(2):13–9.

    Google Scholar 

  49. Mehrdad P, Masoud S, Edris S, Mehrnoush A. Mucinous and non-mucinous adenocarcinoma in colorectal cancer patients. Ann Oncol. 2017;28(3):75–9.

    Google Scholar 

  50. Zahir ST, NazemianYazdi M, Arasteh P, Mortazavizadeh M, Karbalaeian M, ZareMehrjardi M. Clinicopathological features and survival rate of colorectal adenocarcinoma patients with and without a KRAS mutation: a five year study in Yazd, Iran. Asian Pacific J Cancer Prev: APJCP. 2016;17(7):3417–22.

    Google Scholar 

  51. Zare-Bandamiri M, Khanjani N, Jahani Y, Mohammadianpanah M. Factors affecting survival in patients with colorectal cancer in Shiraz, Iran. Asian Pac J Cancer Prev. 2016;17(1):159–63.

    PubMed  Google Scholar 

  52. Madadizadeh F, Ghanbarnejad A, Ghavami V, Bandamiri MZ, Mohammadianpanah M. Applying additive hazards models for analyzing survival in patients with colorectal cancer in Fars Province, Southern Iran. Asian Pacific J Cancer Prev: APJCP. 2017;18(4):1077.

    Google Scholar 

  53. Moamer S, Baghestani A, Pourhoseingholi MA, Hajizadeh N, Ahmadi F, Norouzinia M. Evaluation of prognostic factors effect on survival time in patients with colorectal cancer, based on Weibull Competing-Risks Model. Gastroenterol Hepatol Bed to Bench. 2017;10(1):54–9.

    Google Scholar 

  54. Moamer S, Baghestani AR, Pourhoseingholi MA, Maboudi AAK, Shahsavari S, Zali MR, Majd TM (2017) Application of the parametric regression model with the four-parameter log-logistic distribution for determining of the effecting factors on the survival rate of colorectal cancer patients in the presence of competing risks. Iran Red Crescent Med J 19 (6).

  55. Rasouli MA, Moradi G, Roshani D, Nikkhoo B, Ghaderi E, Ghaytasi B. Prognostic factors and survival of colorectal cancer in Kurdistan province, Iran: a population-based study (2009–2014). Medicine. 2017;96(6):e5941.

    PubMed  PubMed Central  Google Scholar 

  56. Sanei B, Mahmoudieh M, Nasr-Esfahani M. Survival and recurrence time among patients with colon cancer reffered to Alzahra Hospital, Isfahan, Iran, during 2001-2010. J Isfahan Med Sch. 2017;35(431):598–608.

    Google Scholar 

  57. Zare-Bandamiri M, Fararouei M, Zohourinia S, Daneshi N, Dianatinasab M. Risk factors predicting colorectal cancer recurrence following initial treatment: a 5-year cohort study. Asian Pacific J Cancer Prev: APJCP. 2017;18(9):2465–70.

    Google Scholar 

  58. Esna-Ashari F, Sohrabi M, Abadi A, Mehrabian A, Mofid B, Bohluli M, et al. Colorectal cancer prevalence according to survival data in Iran-2007. Iran J Cancer Prev. 2012;2(1):15–8.

    Google Scholar 

  59. Karimi ZA, Saadat A, Jalalian HR, Esmaeili M (2011) Epidemiology and survival analysis of colorectal cancer and its related factors.

  60. Ghadimi M, Mahmoodi M, Mohammad K, Zeraati H, Hosseini M, Sheikh Fathollahi M. Comparison of survival analysis of gastrointestinal Cancer patients using parametric and Cox models. J Sch Public Health Inst Public Health Res. 2010;8(2):1–14.

    Google Scholar 

  61. Fekri N, Parsaee R, Shahid Sales S, Amini A, Esmaeily H. Detection of effective factors in the survival rate of colon cancer patients using survival modeling. J North Khorasan Univ Med Sci. 2013;5(3):621–8. https://doi.org/10.29252/jnkums.5.3.621.

    Article  Google Scholar 

  62. Roshanaei G, Komijani A, Sadighi A, Faradmal J (2014) Prediction of survival in patients with colorectal cancer referred to the Hamadan MRI center using of Weibull parameter model and determination of its risk factors during 2005-2013.

  63. Vakili M, Aghakoochak A, Pirdehghan A, Shiryazdy M, Saffarmoghadam A. The survival rate of patients with colorectal cancer in Yazd during 2001-2011. SSU_J. 2014;22(3):1187–95.

    Google Scholar 

  64. Parsaee R, Fekri N, SHAHID SS, AFZAL AM, Shaarbaf EE, Esmaeily H (2015) Prognostic factors in the survival rate of colorectal cancer patients.

  65. Roudbari M, Abbasi ASL, Barfei F, Gohari MR, Khodabakhshi R. Survival analysis of colorectal cancer patients and its prognostic factors using cox regression. Razi J Med Sci. 2015;22(130):21–8.

    Google Scholar 

  66. Moamar S, Baghestani AR, Pourhoseingholi MA, Maboudi AA (2016) Survival of patients with colorectal cancer based on parametric competing risk survival analysis.

  67. Abdolalian Z, Rafeie M, Baghestani A, Pourhosseingholi M, Daneshvar T. Analyzing the survival of colorectal cancer patients of Tehran Taleghani Hospital using non-mixture cure model. Arak Med Univ J (AMUJ). 2016;19:98–106.

    Google Scholar 

  68. Atefeh Ghorbanzadeh LG AK, Kambiz Akhavan, Abbas Esmaeilzadeh, Ali Bahari, Ali Hadian Far (2016) Survival and its effective factors in patients with colorectal cancer referred to imam Reza hospital in 2005-2015.

  69. Rahimi Pordanjani S, Baeradeh N, Lotfi MH, Pourmohammadi B. Epidemiology of colorectal cancer: incidence, mortality, survival rates and risk factors. Razi J Med Sci. 2016;23(144):41–50.

    Google Scholar 

  70. Ansari R, Amjadi H, Norozbeigi N, Zamani F, Mir-Nasseri S, Khaleghnejad A, et al. Survival analysis of colorectal cancer in patients underwent surgical operation in Shariati and Mehr Hospital-Tehran, in a retrospective study. Govaresh. 2007;12(1):7–15.

    Google Scholar 

  71. Mehrkhani F, Nasiri S, Sorush A, Karamnezhad M, Mehrkhani F, Mosafa S, et al. Prognostic factors in the survival rate of colorectal cancer patients after surgery. Color Dis. 2010;11(2):157–61.

    Google Scholar 

  72. Saedi H, Ghavamnasiri M, Toosi M, Homaei F, Roodbari S. The assessment of prognostic factors in patients with nonmetastatic rectal adenocarcinoma referred to Omid Hospital (Mashhad), Iran. J Gorgan Univ Med Sci. 2009;11(2):28–32.

    Google Scholar 

  73. Mirhosseini SM, Fakhri M, Mozaffary A, Lotfaliany M, Behzadnia N, Ansari Aval Z, et al. Risk factors affecting the survival rate in patients with symptomatic pericardial effusion undergoing surgical intervention. Interact Cardiovasc Thorac Surg. 2012;16(4):495–500.

    PubMed  PubMed Central  Google Scholar 

  74. Baghestani AR, Daneshva T, Pourhoseingholi MA, Asadzadeh H. Survival of colorectal cancer in the presence of competing-risks-modeling by Weibull distribution. Asian Pac J Cancer Prev. 2016;17(3):1193–6.

    PubMed  Google Scholar 

  75. Yoosefi M, Baghestani AR, Pourhoseingholi MA, Baghban AA, Agha SHS, Zali MR. Evaluation of the survival time of the patients with colorectal cancer using exponential model. Govaresh. 2017;22(2):95–100.

    Google Scholar 

  76. Abu-Helalah MA, Alshraideh HA, Abuseif A, Arqoob K, Ajaj A. Delay in presentation, diagnosis and treatment for colorectal cancer patients in Jordan. J Gastrointest Cancer. 2016;47(1):36–46.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hamid Salehiniya.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mozafar Saadati, H., Khodamoradi, F. & Salehiniya, H. Associated Factors of Survival Rate and Screening for Colorectal Cancer in Iran: a Systematic Review. J Gastrointest Canc 51, 401–411 (2020). https://doi.org/10.1007/s12029-019-00275-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-019-00275-0

Keywords

Navigation