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Minimally Invasive Endoscopic Surgery for Treatment of Spontaneous Intracerebral Hematomas: A Single-Center Analysis

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Abstract

Background

Endoscopic minimally invasive surgery to evacuate ICH has been reported to be more effective than conservative treatment or standard surgical craniotomy. However, most of these reports are based on Asian populations, while European reports do not exist. Here, we, therefore, report our experience from a European neurosurgical stroke center.

Methods

The variables assessed were patient characteristics, technical aspects of surgery, surgical complications, the outcomes grade of hematoma evacuation, 30-day mortality, and functional outcome (defined by modified Rankin Scale, mRS). The mRS was dichotomized into favorable (0–3) and unfavorable outcome (4–6). Mortality was compared to external evidence on conservatively and surgically treated patients by Poisson regression analysis with adjustment for ICH score.

Results

Thirty-four patients with ICH were analyzed. The mean age was 62 (standard deviation [SD] 12) years, mean hematoma volume (SD) was 84 (35) ml, and mean time from onset to surgery (SD) was 17 (10) h. Operative times did not exceed 1.5 h. A significant mean hematoma reduction (SD) from 84 (35) ml to 21 (30) ml (p < 0.0001) could be achieved, resulting in a median evacuation rate of 87 %. Early complications related to surgery did not occur. A favorable outcome was observed in 44 % of the patients. Overall, 30-day mortality was 18 %. The relative risk of mortality compared to conventional treatment from other studies was 32 % (95 % confidence interval 23–43 %, p = 0.02).

Conclusions

This European surgical stroke center series of an endoscopic operative technique demonstrates safety and efficacy with regard to reduction of hematoma size in patients with large and space-occupying spontaneous ICH. The study suggests that low mortality and acceptable outcomes may be achievable by minimally invasive hematoma surgery. Whether this technique reduces long-term morbidity compared to standard treatment needs to be further investigated in larger prospective randomized controlled trials.

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Conflict of Interest

The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Neurosurgery, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany

    Berk Orakcioglu, Christopher Beynon & Andreas W. Unterberg

  2. Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany

    Julian Bösel

  3. Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany

    Christian Stock

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  1. Berk Orakcioglu
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  2. Christopher Beynon
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  4. Christian Stock
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Correspondence to Berk Orakcioglu.

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Orakcioglu, B., Beynon, C., Bösel, J. et al. Minimally Invasive Endoscopic Surgery for Treatment of Spontaneous Intracerebral Hematomas: A Single-Center Analysis. Neurocrit Care 21, 407–416 (2014). https://doi.org/10.1007/s12028-014-9987-6

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