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How Patients Die After Intracerebral Hemorrhage

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Abstract

Introduction

Severity of illness scores predict all-cause mortality after intracerebral hemorrhage (ICH), but do not differentiate between proximate mechanisms or predict the timing. We hypothesized that death by neurologic criteria [brain death (BD)], withdrawal of life support, and cardiovascular death would be distinct after ICH.

Methods

We prospectively enrolled patients with spontaneous ICH without underlying vascular malformation or neoplasm. We recorded clinical data and the proximate mechanism of death (BD, withdrawal of life support, cardiovascular death, or other cause). Time to death was compared with Kaplan–Meier methods (log-rank test). Data are median (IQR).

Results

Among 89 patients, 15 had withdrawal of life support, 5 had BD, 2 died from cardiac arrest, and 3 died from other causes. Among patients who died, ICH score, age, Glasgow Coma Scale, NIH Stroke Scale, and proximate cause were not associated with the proximate mechanism of death. The time to death was different (P < 0.001) depending on the proximate mechanism. Patients with BD died 1 [0–1] 1 day after ICH, withdrawal of life support led to death 5 [1–13] days after ICH, cardiac death occurred 35 [35–85] days after ICH, and other causes led to death 33 [26–33] days after ICH. Among patients where life support was withdrawn, a higher ICH score on admission was related to earlier death (P = 0.002).

Conclusions

Proximate mechanisms of death after ICH occur at distinct times. Withdrawal of life support leads to earlier death in patients with a higher severity of injury. Medical causes of death can be effectively prevented after ICH.

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Acknowledgments

Andrew M. Naidech has received research support from NovoNordisk and the Northwestern Memorial Foundation unrelated to this work, and speaker fees from EKR Therapeutics (unrelated to this work).

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Authors and Affiliations

  1. Northwestern University, 710 N Lake Shore Drive 11th Floor, Chicago, 60611, IL, USA

    Andrew M. Naidech, Richard A. Bernstein, Sarice L. Bassin, Rajeev K. Garg, Storm Liebling, Bernard R. Bendok, H. Hunt Batjer & Thomas P. Bleck

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  1. Andrew M. Naidech
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  2. Richard A. Bernstein
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Correspondence to Andrew M. Naidech.

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Naidech, A.M., Bernstein, R.A., Bassin, S.L. et al. How Patients Die After Intracerebral Hemorrhage. Neurocrit Care 11, 45–49 (2009). https://doi.org/10.1007/s12028-009-9186-z

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  • DOI: https://doi.org/10.1007/s12028-009-9186-z

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