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Clinical characteristics and outcome of intracerebral hemorrhage in young adults

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Abstract

Data on determinants of prognosis after intracerebral hemorrhage (ICH) in young adults are scarce. Our aim was to identify clinical determinants of prognosis after ICH in adults aged 18–50. We investigated 98 consecutive patients with an ICH, aged 18–50 years, admitted to our hospital between 1980 and 2010. Collected ICH characteristics included presenting symptoms, etiology, location, severity and Glasgow Coma Scale (GCS). Outcomes were case-fatality (death within 30 days), poor functional outcome (modified Rankin Scale >2), long-term mortality and recurrent ICH. We assessed discriminatory power of factors associated with case-fatality [area under receiver operating curve (AUC)]. Case-fatality was 20.4 % (n = 20) and well predicted by the GCS (AUC 0.83). Among 30-day survivors, a poor functional outcome at discharge was present in 51.3 %. During a mean follow-up of 11.3 years mortality was only increased in patients aged 40–50 years [standardized mortality ratio 4.8 (95 % CI 2.3–8.6)], but not in patients aged 18–40 years. Recurrent ICH occurred in 6 patients [10-year cumulative incidence 12.2 % (95 % CI 1.5–22.9 %)], all with the index ICH attributable to structural vascular malformations. Prognosis after ICH in young adults is poor, mainly due to high case-fatality, that is well predicted by the GCS. An exception is 30-day survivors <40 years, who have a similar risk of dying as the general population. Recurrence risk is especially present in patients with structural vascular malformations, whereas risk seems to be very low in other patients.

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Conflicts of interest

None.

Ethical standard

This study was conducted in accordance with the 1964 Declaration of Helsinki and its later amendments. The medical review ethics committee region Arnhem-Nijmegen approved the study and granted a waiver of consent to collect information on vital status and cause of death. Participants provided written informed consent.

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Authors and Affiliations

  1. Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands

    Loes CA Rutten-Jacobs, Noortje AM Maaijwee, Renate M. Arntz, Hennie C. Schoonderwaldt, Ewoud J. van Dijk & Frank-Erik de Leeuw

  2. Department of Clinical Neurosciences, Neurology Unit, University of Cambridge, Cambridge, UK

    Loes CA Rutten-Jacobs

  3. Department of Neurology, Medisch Spectrum Twente, Enschede, The Netherlands

    Lucille D. Dorresteijn

Authors
  1. Loes CA Rutten-Jacobs
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  2. Noortje AM Maaijwee
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  3. Renate M. Arntz
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  4. Hennie C. Schoonderwaldt
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  5. Lucille D. Dorresteijn
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  6. Ewoud J. van Dijk
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  7. Frank-Erik de Leeuw
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Correspondence to Frank-Erik de Leeuw.

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Rutten-Jacobs, L.C., Maaijwee, N.A., Arntz, R.M. et al. Clinical characteristics and outcome of intracerebral hemorrhage in young adults. J Neurol 261, 2143–2149 (2014). https://doi.org/10.1007/s00415-014-7469-6

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  • DOI: https://doi.org/10.1007/s00415-014-7469-6

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