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Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference

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Abstract

In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.

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Acknowledgments

The authors gratefully acknowledge the support from the William and Ella Owens Medical Research Foundation, the William Stamps Farish Fund, and the State of Texas through the Texas Center for Superconductivity at the University of Houston.

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Authors and Affiliations

  1. Electrical and Computer Engineering Department, University of Houston, Houston, TX, 77204, USA

    Jarek Wosik, Martha Suarez-Villagran & John H. Miller Jr

  2. Texas Center for Superconductivity, University of Houston, HSC Bldg., Rm. 202, Houston, TX, 77204-5002, USA

    Jarek Wosik

  3. Physics Department, University of Houston, Houston, TX, USA

    Martha Suarez-Villagran & John H. Miller Jr

  4. The Houston Methodist Research Institute, Houston, TX, 77030, USA

    Rafik M. Ghobrial & Malgorzata Kloc

  5. Department of Surgery, The Houston Methodist Hospital, 6550 Fannin St., Houston, TX, 77030, USA

    Rafik M. Ghobrial & Malgorzata Kloc

  6. M.D. Anderson Cancer Center, Department of Genetics, The University of Texas, Houston, TX, 77030, USA

    Malgorzata Kloc

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  1. Jarek Wosik
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Wosik, J., Suarez-Villagran, M., Miller, J.H. et al. Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference. Immunol Res 67, 1–11 (2019). https://doi.org/10.1007/s12026-019-9066-3

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