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Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain–Barré syndrome patients

  • PATHOGENESIS AND THERAPY IN AUTOIMMUNE DISEASES
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Abstract

Guillain–Barré syndrome (GBS) is an acute, autoimmune inflammatory disorder of peripheral nervous system characterized by a severe functional motor weakness. Treatment with intravenous immunoglobulin (IVIg) is one of the approved and preferred therapeutic strategies for GBS. However, the mechanisms underlying the therapeutic benefit with IVIg in GBS are not completely understood. In the present study, we observed that GBS patients have increased frequencies of Th1 and Th17 cells, but reduced number of Foxp3+ regulatory T cells (Treg cells) with defective functions. We show that IVIg treatment in GBS patients results in a marked reduction in the frequency of Th1 and Th17 cells with a concomitant expansion of Treg cells. Importantly, IVIg-expanded Treg cells exhibited an increased T cell suppressive function. Together our results demonstrate that therapeutic benefit of IVIg in GBS patients implicates the reciprocal regulation of Th1/Th17 and Treg cells.

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Acknowledgments

This study was supported by Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie, Université Paris Descartes and Journées de Neurologie de Langue Française (M.R.). This work is partially supported by financial support from CSL Behring France.

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Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale Unité 1138, 75006, Paris, France

    Mohan S. Maddur, Magalie Rabin, Pushpa Hegde, Jagadeesh Bayry & Srini V. Kaveri

  2. Centre de Recherche des Cordeliers, Equipe - Immunopathology and Therapeutic Immunointervention, 75006, Paris, France

    Mohan S. Maddur, Magalie Rabin, Pushpa Hegde, Jagadeesh Bayry & Srini V. Kaveri

  3. Sorbonne Universités, UMR S 1138, UPMC Univ Paris 06, 75006, Paris, France

    Mohan S. Maddur, Jagadeesh Bayry & Srini V. Kaveri

  4. UMR S 1138, Université Paris Descartes, 75006, Paris, France

    Mohan S. Maddur, Jagadeesh Bayry & Srini V. Kaveri

  5. Réanimation Neurologique, Neurologie 1, Hôpital de la Pitié-Salpêtrière, 75651, Paris, France

    Francis Bolgert & Moneger Guy

  6. Centre de Référence ‘Neuropathies Périphériques Rares’ et Service de Neurologie, Hôpital Universitaire Limoges, 87042, Limoges, France

    Jean-Michel Vallat & Laurent Magy

  7. International Associated Laboratory IMPACT (Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India), National Institute of Immunohaematology, Mumbai, 400012, India

    Jagadeesh Bayry & Srini V. Kaveri

Authors
  1. Mohan S. Maddur
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  2. Magalie Rabin
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  3. Pushpa Hegde
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  4. Francis Bolgert
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  5. Moneger Guy
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  6. Jean-Michel Vallat
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  7. Laurent Magy
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  8. Jagadeesh Bayry
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  9. Srini V. Kaveri
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Corresponding authors

Correspondence to Jagadeesh Bayry or Srini V. Kaveri.

Additional information

Mohan S. Maddur and Magalie Rabin have contributed equally to this work.

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Maddur, M.S., Rabin, M., Hegde, P. et al. Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain–Barré syndrome patients. Immunol Res 60, 320–329 (2014). https://doi.org/10.1007/s12026-014-8580-6

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  • DOI: https://doi.org/10.1007/s12026-014-8580-6

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