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Pituitary Adenoma with Tumoral Granulomatous Reaction

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Abstract

Herein, we report a unique case of an adult male with a corticotrophic pituitary adenoma of silent subtype 1 exhibiting conspicuous idiopathic tumoral noncaseating granulomatous inflammation. The lesion was unassociated with clinical or laboratory evidence of either systemic sarcoidosis or infection. Histochemical and polymerase chain reaction (PCR) studies revealed neither fungi nor tubercle bacilli. We suggest that tumoral production of an as yet uncharacterized antigen may have induced the granulomatous inflammatory reaction.

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Acknowledgment

The authors express their appreciation to Seanne P. Buckwalter, M.S. and Dr. Nancy L. Wengenack of the Division of Microbiology, Mayo Clinic, for performance of PCR reactions and to Mr. and Mrs. Jarislowsky and the Lloyd Carr-Harris Foundations for their generous financial support. We also acknowledge the expert secretarial support of Mrs. Denise Chase.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Bernd W. Scheithauer, Ana Isabel Silva & Ricardo Lloyd

  2. Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA

    John L. D. Atkinson

  3. Department of Endocrinology and Metabolism, Mayo Clinic, Rochester, MN, USA

    Todd B. Nippoldt

  4. Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN, USA

    Timothy J. Kaufmann

  5. Department of Pathology, Hospital Sao Marcos, Braga, Portugal

    Ana Isabel Silva

  6. Department of Pathology, St. Michael’s Hospital, Toronto, ON, Canada

    Kalman Kovacs & Eva Horvath

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  1. Bernd W. Scheithauer
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  2. Ana Isabel Silva
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  3. John L. D. Atkinson
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  8. Ricardo Lloyd
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Correspondence to Bernd W. Scheithauer.

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Scheithauer, B.W., Silva, A.I., Atkinson, J.L.D. et al. Pituitary Adenoma with Tumoral Granulomatous Reaction. Endocr Pathol 18, 86–90 (2007). https://doi.org/10.1007/s12022-007-0017-5

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