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System for Integrated Neuroimaging Analysis and Processing of Structure

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Abstract

Mapping brain structure in relation to neurological development, function, plasticity, and disease is widely considered to be one of the most essential challenges for opening new lines of neuro-scientific inquiry. Recent developments with MRI analysis of structural connectivity, anatomical brain segmentation, cortical surface parcellation, and functional imaging have yielded fantastic advances in our ability to probe the neurological structure-function relationship in vivo. To date, the image analysis efforts in each of these areas have typically focused on a single modality. Here, we extend the cortical reconstruction using implicit surface evolution (CRUISE) methodology to perform efficient, consistent, and topologically correct analyses in a natively multi-parametric manner. This effort combines and extends state-of-the-art techniques to simultaneously consider and analyze structural and diffusion information alongside quantitative and functional imaging data. Robust and consistent estimates of the cortical surface extraction, cortical labeling, diffusion-inferred contrasts, diffusion tractography, and subcortical parcellation are demonstrated in a scan-rescan paradigm. Accompanying this demonstration, we present a fully automated software system complete with validation data.

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Acknowledgments

The authors are appreciative of the careful feedback from the anonymous reviewers and editor (Dr. David Kennedy). This research was supported by NIH/NIA N01-AG-4-0012, NINDS 5R01NS070906, 1R03EB012461, 1R01NS056307, NIH/NIDAK25DA025356 (Bazin), and NIH/NINDSR01NS054255 (Pham).

Grant Support

J. L. Prince/B. A. Landman (subcontract): NIH/NIA N01-AG-4-0012, J. Prince: 1R01NS056307, B. Landman 1R03EB012461.

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Authors and Affiliations

  1. Department of Electrical Engineering, Vanderbilt University, 2301 Vanderbilt Pl., Station B, PO Box 351679, Nashville, TN, 37235-1679, USA

    Bennett A. Landman

  2. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA

    Bennett A. Landman & Jerry L. Prince

  3. The Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA

    Bennett A. Landman

  4. Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA

    John A. Bogovic, Aaron Carass, Min Chen, Snehashis Roy, Navid Shiee, Zhen Yang, Dzung Pham & Jerry L. Prince

  5. The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Bhaskar Kishore, Dzung Pham & Jerry L. Prince

  6. Center for Neuroscience and Regenerative Medicine, Washington, DC, USA

    Dzung Pham

  7. Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD, USA

    Susan M. Resnick

  8. Department of Neurophysics, Max Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

    Pierre-Louis Bazin

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  1. Bennett A. Landman
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Corresponding author

Correspondence to Bennett A. Landman.

Appendix A

Appendix A

The regions indicated in Fig. 6 are as defined by (Desikan et al. 2006) and indexed as follows. 1 : L-Subcortical Region, 2 : L-Banks of Superior Temporal Sulcus, 3 : L-Caudal Anterior Cingulate, 4 : L-Caudal Middle Frontal, 5 : L-Corpus Callosum, 6 : L-Cuneus, 7 : L-Entorhinal 8 : L-Fusiform, 9 : L-Inferior Parietal, 10 : L-Inferior Temporal, 11 : L-Isthmus, 12 : L-Lateral Occipital, 13 : L-Lateral Orbitofrontal, 14 : L-Lingual, 15 : L-Medial Orbitofrontal, 16 : L-Middle Temporal, 17 : L-Parahippocampal, 18 : L-Paracentral, 19 : L-Pars Opercularis, 20 : L-Pars Orbitalis, 21 : L-Pars Triangularis, 22 : L-Pericalcarine, 23 : L-Postcentral, 24 : L-Posterior Cingulate, 25 : L-Precentral, 26 : L-Precuneus, 27 : L-Rostral Anterior Cingulate, 28 : L-Rostral Middle Frontal, 29 : L-Superior Frontal, 30 : L-Superior Parietal, 31 : L-Superior Temporal, 32 : L-Supramarginal, 33 : L-Frontal Pole, 34 : L-Temporal Pole, 35 : L-Transverse Temporal, 36 : R-Subcortical Region, 37 : R-Banks of the Superior Temporal Sulcus, 38 : R-Caudal Anterior Cingulate, 39 : R-Caudal Middle Frontal, 40 : R-Corpus Callosum, 41 : R-Cuneus, 42 : R-Entorhinal, 43 : R-Fusiform, 44 : R-Inferior Parietal, 45 : R-Inferior Temporal, 46 : R-Isthmus, 47 : R-Lateral Occipital, 48 : R-Lateral Orbitofrontal, 49 : R-Lingual, 50 : R-Medial Orbitofrontal, 51 : R-Middle Temporal, 52 : R-Parahippocampal, 53 : R-Paracentral, 54 : R-Pars Opercularis, 55 : R-Pars Orbitalis, 56 : R-Pars Triangularis, 57 : R-Pericalcarine, 58 : R-Postcentral, 59 : R-Posterior Cingulate, 60 : R-Precentral, 61 : R-Precuneus, 62 : R-Rostral Anterior Cingulate, 63 : R-Rostral Middle Frontal,64 : R-Superior Frontal, 65 : R-Superior Parietal, 66 : R-Superior Temporal, 67 : R-Supramarginal, 68 : R-Frontal Pole, 69 : R-Temporal Pole, 70 : R-Transverse Temporal

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Landman, B.A., Bogovic, J.A., Carass, A. et al. System for Integrated Neuroimaging Analysis and Processing of Structure. Neuroinform 11, 91–103 (2013). https://doi.org/10.1007/s12021-012-9159-9

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