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Effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction

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Abstract

The influence of glucagon-like peptide-1 has been studied in several studies in patients with acute myocardial infarction, but not in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We planned to evaluate the effects of liraglutide on left ventricular function in patients with NSTEMI. A total of 90 patients were randomized 1:1 to receive either liraglutide (0.6 mg for 2 days, 1.2 mg for 2 days, followed by 1.8 mg for 3 days) or placebo for 7 days. Eighty-three patients completed the trial. Transthoracic echocardiography was used to assess left ventricular function. At 3 months, the primary endpoint, the difference in the change in left ventricular ejection fraction between the two groups was +4.7 % (liraglutide vs. placebo 95 % CI +0.7 to +9.2 % P = 0.009) under intention-to-treat analysis. The difference in decrease in serum glycosylated hemoglobin levels was −0.2 % (liraglutide vs. placebo 95 % CI −0.1 to −0.3 %; P < 0.001). Inflammation and oxidative stress improved significantly in the liraglutide group compared to the placebo group. Liraglutide could improve left ventricular function in patients with NSTEMI, making it a potential adjuvant therapy for NSTEMI.

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Acknowledgments

We express our sincere appreciation to all participants in this study. We also thank Ping Jian Guo, Hang Yu, and Chang Fu Liu, who assisted in this study.

Contributors

All authors have substantially contributed to the manuscript in terms of conception and design, analysis and interpretation of data, drafting the article, revising it critically for important intellectual content, and final approval of the version.

Funding

This study was supported by the National Natural Science Foundation of China (Fund Number 81441008).

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    Authors and Affiliations

    1. Department of Cardiology, PLA General Hospital at Beijing, Beijing, China

      Wei-Ren Chen, Ying Zhang, Yun-Dai Chen, Shun-Ying Hu, Geng Qian, Jing Wang, Jun-Jie Yang, Zhi-Feng Wang & Feng Tian

    2. International Medical Centre, PLA General Hospital at Beijing, Beijing, China

      Xue-Qin Shen

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    Wei-Ren Chen and Xue-Qin Shen have contributed equally to this work.

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    Chen, WR., Shen, XQ., Zhang, Y. et al. Effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction. Endocrine 52, 516–526 (2016). https://doi.org/10.1007/s12020-015-0798-0

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