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Role of BMP7 in appetite regulation, adipogenesis, and energy expenditure

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Abstract

Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions. This review will also discuss the synthesis and action of BMP7, along with its receptors and signal transduction. A brief note about BMP7-mediated brown fat development and energy balance is also discussed.

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Authors and Affiliations

  1. Endocrinology and Metabolism Division, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India

    Supriya Saini, Arul Joseph Duraisamy, Susovon Bayen & Praveen Vats

  2. Department of Applied Physiology, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India

    Shashi Bala Singh

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  1. Supriya Saini
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  2. Arul Joseph Duraisamy
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  4. Praveen Vats
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Correspondence to Praveen Vats.

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Saini, S., Duraisamy, A.J., Bayen, S. et al. Role of BMP7 in appetite regulation, adipogenesis, and energy expenditure. Endocrine 48, 405–409 (2015). https://doi.org/10.1007/s12020-014-0406-8

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