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Association between CTLA-4 genetic polymorphisms and susceptibility to osteosarcoma in Chinese Han population

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Abstract

Osteosarcoma (OS) is the most common malignant primary bone tumor in the world. The cytotoxic T-lymphocyte antigen-4 gene (CTLA-4) is an important candidate gene for influencing the development of OS. This study aimed to investigate the potential association of CTLA-4 genetic polymorphisms with OS risk in Chinese Han population. A total of 415 OS patients and 431 healthy controls were enrolled in this study. The created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods were used to detect the genotyping of CTLA-4 c.75G>C and c.326G>A genetic polymorphisms. We observed that the genotypes/alleles of c.75G>C and c.326G>A genetic polymorphisms were statistically associated with the increased risk of OS (for c.75G>C, CC versus (vs.) GG: OR 1.72, 95 % CI 1.09–2.74; C vs. G: OR 1.30, 95 % CI 1.06–1.60; for c.326G>A, AA vs. GG: OR 2.12, 95 % CI 1.31–3.42; A vs. G: OR 1.31, 95 % CI 1.07–1.61). The allele-C/genotype-CC of c.75G>C and allele-A/genotype-AA of c.326G>A may contribute to OS susceptibility. These data indicate that CTLA-4 genetic polymorphisms are potentially related to OS risk in Chinese Han population, and might be used as molecular markers for evaluating the risk of OS.

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Authors and Affiliations

  1. Department of Spine, The Second Xiangya Hospital Affiliated with Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan Province, People’s Republic of China

    Jinshan He & Guohua Lv

  2. Department of Orthopedics, Subei People’s Hospital, Clinical Medical School of Yangzhou University, Yangzhou, 225001, Jiangsu Province, People’s Republic of China

    Jinshan He, Jingcheng Wang, Daxin Wang, Shanhe Dai, Tangyun Yv, Pengtao Chen, Renshi Ma & Chunyv Diao

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  1. Jinshan He
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  2. Jingcheng Wang
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Correspondence to Guohua Lv.

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He, J., Wang, J., Wang, D. et al. Association between CTLA-4 genetic polymorphisms and susceptibility to osteosarcoma in Chinese Han population. Endocrine 45, 325–330 (2014). https://doi.org/10.1007/s12020-013-0050-8

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