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Horizons in Sjögren’s Syndrome Genetics

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Abstract

Sjögren’s syndrome (SS) is a complex polygenic autoimmune disorder. A few major genetic effects have been identified. Historically, HLA and non-HLA genetic associations have been reported. Recently, the HLA region continued to reveal association findings. A new susceptibility region has been suggested by a study of a D6S349 microsatellite marker. Among non-HLA studies, recent association of immunoglobulin κ chain allotype KM1 with anti-La autoantibodies in primary Sjögren’s syndrome confirms findings in a study from two decades ago. Meanwhile, mouse models have been employed to study the genetic contribution to salivary lymphadenitis or dry eyes and mouth. Gene transfer exploration in mouse models shows promise. The authors review the HLA and non-HLA association studies and the mouse model work that has been reported. Newly developed genomic capacity will provide, in the future, a much closer approximation of the true picture of the genetic architecture of Sjögren’s syndrome.

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Acknowledgments

We appreciate support of the NIH grants AR42460, AR12253, AI24717, AI31584, AR049084, RR020143, AR048940, and DE015223 (JBH), NIH grant number P20-RR015577 from the National Center for Research Resources (AHS), and US Department of Veteran Affairs (CC103) for our work.

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Authors and Affiliations

  1. Arthritis and Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA

    Pamela H. Williams, Beth L. Cobb, Bahram Namjou, R. Hal Scofield, Amr H. Sawalha & John B. Harley

  2. Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    R. Hal Scofield, Amr H. Sawalha & John B. Harley

  3. US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA

    R. Hal Scofield, Amr H. Sawalha & John B. Harley

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  1. Pamela H. Williams
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Correspondence to John B. Harley.

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Williams, P.H., Cobb, B.L., Namjou, B. et al. Horizons in Sjögren’s Syndrome Genetics. Clinic Rev Allerg Immunol 32, 201–209 (2007). https://doi.org/10.1007/s12016-007-8002-9

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