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Advances in Progenitor Cell Therapy Using Scaffolding Constructs for Central Nervous System Injury

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Abstract

Traumatic brain injury (TBI) is a major cause of morbidity and mortality in the United States. Current clinical therapy is focused on optimization of the acute/subacute intracerebral milieu, minimizing continued cell death, and subsequent intense rehabilitation to ameliorate the prolonged physical, cognitive, and psychosocial deficits that result from TBI. Adult progenitor (stem) cell therapies have shown promise in pre-clinical studies and remain a focus of intense scientific investigation. One of the fundamental challenges to successful translation of the large body of pre-clinical work is the delivery of progenitor cells to the target location/organ. Classically used vehicles such as intravenous and intra arterial infusion have shown low engraftment rates and risk of distal emboli. Novel delivery methods such as nanofiber scaffold implantation could provide the structural and nutritive support required for progenitor cell proliferation, engraftment, and differentiation. The focus of this review is to explore the current state of the art as it relates to current and novel progenitor cell delivery methods.

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Authors and Affiliations

  1. Department of Surgery, University of Texas Medical School at Houston, Houston, TX, USA

    Peter A. Walker, Kevin R. Aroom, Fernando Jimenez, Shinil K. Shah, Matthew T. Harting, Brijesh S. Gill & Charles S. Cox Jr

  2. Department of Pediatric Surgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 5.236, Houston, TX, 77030, USA

    Peter A. Walker, Kevin R. Aroom, Fernando Jimenez, Shinil K. Shah, Matthew T. Harting & Charles S. Cox Jr

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  1. Peter A. Walker
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Supported by grants: NIH T32 GM 08 79201; NIH P018/N01 HB 37163; M01 RR 02558; Texas Higher Education Coordinating Board; Children’s Memorial Hermann Hospital Foundation

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Walker, P.A., Aroom, K.R., Jimenez, F. et al. Advances in Progenitor Cell Therapy Using Scaffolding Constructs for Central Nervous System Injury. Stem Cell Rev and Rep 5, 283–300 (2009). https://doi.org/10.1007/s12015-009-9081-1

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