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Cardioprotective Effect of Anisodamine Against Myocardial Ischemia Injury and its Influence on Cardiomyocytes Apoptosis

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Abstract

Anisodamine is an ancient Chinese medicine derived from Tibet as a belladonna alkaloid, which is usually used for improvement of blood circulation in patients with organ phosphorus poisoning or shock. In this study, for the first time, we report its cardioprotective effects on preventing ischemia/reperfusion (I/R) injury of patients with acute myocardial infarction (AMI), and decreasing the myocardial infarction area and severity in heart of Sprague–Dawley (SD) rats. Our results suggest a potential molecular mechanism of anisodamine against the I/R injury in cardiomyocytes is associated with its anti-apoptotic effect. Anisodamine treatment decreases the expression of caspase-3 and caspase-8, and increases Bcl-2/Bax ratio in cardiomyocytes. Our data suggest that anisodamine can provide significant cardioprotection against I/R injury, potentially through the suppression of cardiomyocytes apoptosis.

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Authors and Affiliations

  1. Hebei Medical University, Shijiazhuang City, Hebei Province, China

    Kun Xing, Lingling Jiang, Shiru Bai & Xile Bi

  2. Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, China

    Xianghua Fu, Yanbo Wang, Wei Li, Xinshun Gu, Guozhen Hao & Qing Miao

  3. Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang City, Hebei Province, China

    Xiaolin Ge

  4. Bethune International Hospital of Chinese PLA, Shijiazhuang City, Hebei Province, China

    Yuhong Peng

  5. The No.1 Hospital of Baoding City, Baoding City, Hebei Province, China

    Wei Geng

  6. The First Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, China

    Liye Wei

Authors
  1. Kun Xing
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  2. Xianghua Fu
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  3. Lingling Jiang
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  4. Yanbo Wang
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  5. Wei Li
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  6. Xinshun Gu
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  7. Guozhen Hao
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  8. Qing Miao
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  9. Xiaolin Ge
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  10. Yuhong Peng
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  11. Wei Geng
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  12. Shiru Bai
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  13. Liye Wei
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  14. Xile Bi
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Correspondence to Xianghua Fu.

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Xing, K., Fu, X., Jiang, L. et al. Cardioprotective Effect of Anisodamine Against Myocardial Ischemia Injury and its Influence on Cardiomyocytes Apoptosis. Cell Biochem Biophys 73, 707–716 (2015). https://doi.org/10.1007/s12013-015-0642-4

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  • DOI: https://doi.org/10.1007/s12013-015-0642-4

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