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Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer

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Abstract

Gastric cancer has high morbidity and mortality. Identification of patients with high gastric cancer risk at early stage will improve patient prognosis. In this study, we examined two single nucleotide polymorphism (SNP) sites of COX-2 gene in gastric cancer patients and explored the effect of the SNPs on the morbidity of gastric cancer. We found that the SNPs COX-2-1195G/A and COX-2-8473T/C are correlated with the occurrence of gastric cancer, and the patients with variants A and C of the SNPs are liable to have gastric cancer. Our study provides a potential method for screening of susceptible population of gastric cancer for early-stage intervention in patients.

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Authors and Affiliations

  1. Department of Clinical Laboratory, The People’s Hospital of Wenshan Prefecture, No. 228, Kaihua Middle Road, Wenshan City, 663000, Yunnan, China

    Xingre Lu, Fengyu Chen, Xiaowen Liu, Diao Yuan, Yunju Zi, Xiang He & Running He

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  1. Xingre Lu
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  2. Fengyu Chen
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  3. Xiaowen Liu
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  4. Diao Yuan
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  5. Yunju Zi
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  6. Xiang He
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  7. Running He
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Correspondence to Xingre Lu.

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Lu, X., Chen, F., Liu, X. et al. Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer. Cell Biochem Biophys 72, 657–660 (2015). https://doi.org/10.1007/s12013-014-0465-8

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  • DOI: https://doi.org/10.1007/s12013-014-0465-8

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