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Accelerated Regeneration of Skin Injury by Co-transplantation of Mesenchymal Stem Cells from Wharton’s Jelly of the Human Umbilical Cord Mixed with Microparticles

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Abstract

This study was set to explore a new strategy for repairing skin wounds, co-transplantation of mesenchymal stem cells from Wharton’s Jelly of the human umbilical cord (hUC-Wharton’s jelly-MSCs) and microparticles. A mixture of hUC-Wharton’s jelly-MSCs and microparticles was co-transplanted to 10-mm diameter, full-thickness, mid-dorsal, excisional skin wounds of mice. After 7, 14, and 21 days, the tissue sections were sampled for reconstruction analysis and histological examination. Our results showed that hUC-Wharton’s jelly-MSCs possess the potentials for multi-directional differentiation. After co-transplantation, there was remarkable development of newborn skin and its appendages. Newly generated layers of epidermis, sebaceous glands, hair follicle, and sweat glands were observed. This promising innovative strategy could significantly increase the quality of repair and regeneration of skin after injuries.

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Authors and Affiliations

  1. Burns Department, Zhujing Hospital, Southern Medical University, Guangzhou, 510280, China

    Shengjun Shi, Siyuan Jia & Guangping Chen

  2. Endocrinology Department, Guangdong No.2 Province People’s Hospital, Guangzhou, 510317, China

    Jingwen Liu

Authors
  1. Shengjun Shi
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  2. Siyuan Jia
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  3. Jingwen Liu
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  4. Guangping Chen
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Correspondence to Jingwen Liu.

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Shi, S., Jia, S., Liu, J. et al. Accelerated Regeneration of Skin Injury by Co-transplantation of Mesenchymal Stem Cells from Wharton’s Jelly of the Human Umbilical Cord Mixed with Microparticles. Cell Biochem Biophys 71, 951–956 (2015). https://doi.org/10.1007/s12013-014-0292-y

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  • DOI: https://doi.org/10.1007/s12013-014-0292-y

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