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Propofol Administration Modulates AQP-4 Expression and Brain Edema After Traumatic Brain Injury

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Abstract

The increased intracranial pressure caused by brain edema following traumatic brain injury (TBI) always leads to poor patient prognosis. Aquaporin-4 (AQP-4) plays an important role in edema formation and resolution, which may provide a novel therapeutic target for edema treatment. In this present study, we found that propofol treatment, within a short time, after TBI significantly reduced brain edema in a controlled cortical injury rat model and suppressed in vivo expression of AQP-4. The ameliorating effect of propofol was associated with attenuated expression of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). In addition, the regulatory effect of propofol on AQP-4 expression was investigated in cultured astrocytes. Results showed that propofol could block the stimulatory effect of IL-1β and TNF-α on AQP-4 expression in cultured astrocytes. We also found that both NFκB and p38/MAPK pathways were involved in IL-1β and TNF-α-induced AQP-4 expression and that propofol functions as a dual inhibitor of NFκB and p38/MAPK pathways. In conclusion, treatment with propofol, within a short time, after TBI attenuates cerebral edema and reduces the expression of AQP-4. Propofol modulates acute AQP-4 expression by attenuating IL-1β and TNF-α expression and inhibiting IL-1β and TNF-α induced AQP-4 expression.

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Authors and Affiliations

  1. Emergency Center, The Affiliated Wuxi People’s Hospital, Nanjing Medical University, Wuxi, 214023, China

    Zhongyang Ding, Jiaming Zhang, Jinyu Xu, Guangjie Sheng & Guorong Huang

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  1. Zhongyang Ding
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  2. Jiaming Zhang
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Correspondence to Zhongyang Ding.

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Ding, Z., Zhang, J., Xu, J. et al. Propofol Administration Modulates AQP-4 Expression and Brain Edema After Traumatic Brain Injury. Cell Biochem Biophys 67, 615–622 (2013). https://doi.org/10.1007/s12013-013-9549-0

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