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Effects of Atorvastatin on Pathological Changes in Brain Tissue and Plasma MMP-9 in Rats with Intracerebral Hemorrhage

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Abstract

To explore the effects of atorvastatin on hydrocephalus, neurocyte apoptosis, and the level of plasma matrix metalloproteinase-9 (MMP-9) after intracerebral hemorrhage (ICH) in rats. A rat model of ICH was established by intracerebral injection of collagenase. The brain water content was determined by the wet/dry weight ratio, ultrastructural changes in brain tissue were observed by electron microscopy, and the level of plasma MMP-9 was quantified by ELISA. Atorvastatin showed significant effects in reducing the brain water content, blocking neuron apoptosis, and decreasing plasma MMP-9 in rats with ICH. There was a positive linear correlation between plasma MMP-9 and the brain water content. Atorvastatin can significantly relieve brain edema, decrease the brain injury caused by MMP-9 and protect neurons in rats with ICH.

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References

  1. Wu, J. (Ed.). (2005). Neurology (Vol. 8, pp. 170–174). Beijing: The People’s Medical Publishing House.

  2. Hua, Y., Xi, G., Keep, R. F., et al. (2000). Complement activation in the brain after experimental hemorrhage. Journal of Neurosurgery, 92(6), 1016.

    Article  PubMed  CAS  Google Scholar 

  3. Karki, K., Knight, R. A., Han, Y., et al. (2009). Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage. Stroke, 40(10), 3384–3389.

    Article  PubMed  CAS  Google Scholar 

  4. Rosenberg, G. A., Mun-Bryce, S., Wesley, M., et al. (1990). Collagenase induced intracerebral hemorrhage in rats. Stroke, 21(5), 801–807.

    Article  PubMed  CAS  Google Scholar 

  5. Niizuma, K., Endo, H., & Chan, P. H. (2009). Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. Journal of Neurochemistry, 109(Suppl 1), 133–138.

    Article  PubMed  CAS  Google Scholar 

  6. Rosell, A., Cuadrado, E., Ortega-Aznar, A., et al. (2008). MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke, 39(4), 1121–1126.

    Article  PubMed  CAS  Google Scholar 

  7. Wu, C. H., Huang, F. Y., Wang, K. Y., et al. (2008). Expression of matrix metalloproteinase MMP-9 in the plasma and hematoma fluid of intracerebral hemorrhage patients. Zhonghua Yi Xue Za Zhi, 88(3), 174–176.

    PubMed  CAS  Google Scholar 

  8. Hogue, J. C., Lamarche, B., Tremblay, A. J., et al. (2008). Differential effect of atorvastatin and fenofibrate on plasma oxidized low-density lipoprotein, inflammation markers, and cell adhesion molecules in patients with type 2 diabetes mellitus. Metabolism, 57(3), 380–386.

    Article  PubMed  CAS  Google Scholar 

  9. Chu, C. S., Lee, K. T., Lee, M. Y., et al. (2006). Effects of rosiglitazone alone and in combination with atorvastatin on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. American Journal of Cardiology, 97(5), 646–650.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

This study is sponsored by Science Technology Project of Binzhou Medical College (BY2007KJ44).

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Authors and Affiliations

  1. Department of Cardiovasology, Affiliated Hospital, Binzhou Medical College, Binzhou, 256600, China

    Jing-Jing Cui, Dong Wang, Fei Gao & Yue-Rong Li

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  1. Jing-Jing Cui
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  2. Dong Wang
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  3. Fei Gao
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  4. Yue-Rong Li
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Correspondence to Dong Wang.

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Cui, JJ., Wang, D., Gao, F. et al. Effects of Atorvastatin on Pathological Changes in Brain Tissue and Plasma MMP-9 in Rats with Intracerebral Hemorrhage. Cell Biochem Biophys 62, 87–90 (2012). https://doi.org/10.1007/s12013-011-9264-7

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  • DOI: https://doi.org/10.1007/s12013-011-9264-7

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