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Resistance training improves cardiac function and cardiovascular autonomic control in doxorubicin-induced cardiotoxicity

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Abstract

Doxorubicin (DOX) is an anticancer chemotherapy drug that is widely used in clinical practice. It is well documented that DOX impairs baroreflex responsiveness and left ventricular function and enhances sympathetic activity, cardiac sympathetic afferent reflexes and oxidative stress, which contribute to hemodynamic deterioration. Because resistance training (RT)-induced cardioprotection has been observed in other animal models, the objective of this study was to assess the effects of RT during DOX treatment on hemodynamics, arterial baroreflex, cardiac autonomic tone, left ventricular function and oxidative stress in rats with DOX-induced cardiotoxicity. Male Wistar rats were submitted to a RT protocol (3 sets of 10 repetitions, 40% of one-repetition maximum (1RM) of intensity, 3 times per week, for 8 weeks). The rats were separated into 3 groups: sedentary control, DOX sedentary (2.5 mg/kg of DOX intraperitoneal injection, once a week, for 6 weeks) and DOX + RT. After training or time control, the animals were anesthetized and 2 catheters were implanted for hemodynamic, arterial baroreflex and cardiac autonomic tone. Another group of animals was used to evaluate left ventricular function. We found that RT in DOX-treated rats decreased diastolic arterial pressure, heart rate, sympathetic tone and oxidative stress. In addition, RT increased arterial baroreflex sensitivity, vagal tone and left ventricular developed pressure in rats with DOX-induced cardiotoxicity. In summary, RT is a useful non-pharmacological strategy to attenuate DOX-induced cardiotoxicity.

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Acknowledgements

We thank the Brazilian Board of Scientific and Technological Development (CNPq), the Coordination for the Improvement of Higher-Level-Education Personnel (CAPES) and the Foundation for Support to Technological Research and Innovation of the State of Sergipe (FAPITEC-SE) for the financial support.

Funding

Brazilian Board of Scientific and Technological Development (CNPq), the Coordination for the Improvement of Higher-Level-Education Personnel (CAPES) and the Foundation for Support to Technological Research and Innovation of the State of Sergipe (FAPITEC-SE).

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Authors and Affiliations

  1. Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil

    Larissa Andrade de Sá Feitosa, Cácia Oliveira Dantas, Diego Santos de Souza, Carla Maria Lins de Vasconcelos, Rodrigo Miguel-dos-Santos, Sandra Lauton-Santos, Lucindo José Quíntans-Júnior, Márcio Roberto Viana Santos & Valter Joviniano de Santana-Filho

  2. Department of Health Education, Federal University of Sergipe, Lagarto, Sergipe, Brazil

    Jéssica dos Santos Carvalho & André Sales Barreto

  3. Cardiac Exercise Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

    Rodrigo Miguel-dos-Santos

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Feitosa, L.A.d., Carvalho, J.d.S., Dantas, C.O. et al. Resistance training improves cardiac function and cardiovascular autonomic control in doxorubicin-induced cardiotoxicity. Cardiovasc Toxicol 21, 365–374 (2021). https://doi.org/10.1007/s12012-020-09627-w

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