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Nano-Molybdenum and Macleaya cordata Extracts Improved Antioxidant Capacity of Grazing Nanjiang Brown Goats on Copper and Cadmium-Contaminated Prairies

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Abstract

To investigate the effects of nano-ammonium octamolybdate (nano-Mo) and Macleaya cordata extracts (MCE) on antioxidant capacity of grazing Nanjiang brown goats on natural prairies under Cu and Cd stress, a 2 × 2 factorial design was adopted in this test, and two factors were nano-Mo (0, 10 mg/kg) and MCE (0, 3000 mg/kg). 24 hm2 polluted grassland was used in this 30-day trial and was equally divided into twelve fenced units. A total of 36 Nanjiang brown goats (1 year old) with an average body weight (BW) of 40.9 ± 2.1 kg were used in this test. The dietary treatments were (1) CON group, basic diet; (2) Nano-Mo group, basic diet + 10 mg/kg added Mo (nano-Mo); (3) MCE group, basic diet + 3000 mg/kg added MCE; and (4) combined group, basic diet + 10 mg/kg added nano-Mo and 3000 mg/kg added MCE. Nano-Mo or combination of nano-Mo and MCE diets significantly decreased the Cu content in serum and the liver of grazing goats (P < 0.05) and increased the Fe and Mo contents in serum and the liver (P < 0.05). The supplementation of nano-Mo, MCE, and combined diets extremely increased the levels of blood Hb, RBC, and PCV (P < 0.05), as well as the activities of serum SOD, GSH-Px, CAT, and Cp (P < 0.05), and greatly decreased the blood WBC content (P < 0.05) and the serum MDA content (P < 0.05). In conclusion, the application of nano-Mo and/or MCE diets on contaminated grasslands changed the contents of mineral elements in serum and the liver of grazing goats, reduced oxidative stress, and improved antioxidant capacity. The combination of nano-Mo and MCE can alleviate the toxic damage of combined heavy metal contaminations.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. Gao JQ, Yu Y, Wang DH, Liu LJ (2019) The content and distribution characteristics of heavy metals in root soils in the Jiajika Lithium resource area Western Sichuan Province. Rock Miner Anal 38(6):381–392

    Google Scholar 

  2. Hu WY, Wang HF, Dong LR, Huang BA, Borggaard OK, Hansen HCB, He Y, Holm PE (2018) Source identification of heavy metals in peri-urban agricultural soils of southeast China: an integrated approach. Environ Pollut 237:650–661

    Article  CAS  Google Scholar 

  3. Ravindra K, Mor S (2019) Distribution and health risk assessment of arsenic and selected heavy metals in groundwater of Chandigarh, India. Environ Pollut 250:820–830

    Article  CAS  Google Scholar 

  4. Li HX, Ji HB, Shi CJ, Gao Y, Zhang Y, Xu XY, Ding HJ, Tang L, Xing YX (2017) Distribution of heavy metals and metalloids in bulk and particle size fractions of soils from coalmine brownfield and implications on human health. Chemosphere 172:505–515

    Article  CAS  Google Scholar 

  5. Li YF, Shen XY, Liu FY, Luo L, Wang YC (2021) Molybdenum fertilization improved antioxidant capacity of grazing Nanjiang brown goat on copper-contaminated pasture. Biol Trace Elem Res. https://doi.org/10.1007/s12011-021-02735-w

    Article  PubMed  PubMed Central  Google Scholar 

  6. Nie J, Liu YG, Zeng GM, Zheng BH, Tan XF, Liu H, Xie JL, Gan C, Liu W (2016) Cadmium accumulation and tolerance of Macleaya cordata: a newly potential plant for sustainable phytoremediation in Cd-contaminated soil. Environ Sci Pollut Res 23(10):10189–10199

    Article  CAS  Google Scholar 

  7. Zhou SH, Zhang CY, Xiao QY, Zhuang Y, Gu XL, Yang F, Xing CH, Hu GL, Cao HB (2016) Effects of different levels of molybdenum on rumen microbiota and trace elements changes in tissues from goats. Biol Trace Elem Res 174(1):85–92

    Article  CAS  Google Scholar 

  8. Li YF, He J, Luo L, Wang YC (2021) The combinations of sulfur and molybdenum fertilization improved antioxidant capacity in grazing Nanjiang brown goat. Biol Trace Elem Res. https://doi.org/10.1007/s12011-021-02702-5

    Article  PubMed  PubMed Central  Google Scholar 

  9. Li YF, Wang YC, Shen XY, Liu FY (2021) The combinations of sulfur and molybdenum fertilizations improved antioxidant capacity of grazing Guizhou semi-fine wool sheep under copper and cadmium stress. Ecotoxicol Environ Saf 222:112520

    Article  CAS  Google Scholar 

  10. Lee MT, Lin WC, Yu B, Lee TT (2017) Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals-a review. Asian-Austral J Anim Sci 30(3):299–308

    Article  CAS  Google Scholar 

  11. Chen JQ, Zhang S, Tong JY, Teng XJ, Zhang ZY, Li S, Teng XH (2020) Whole transcriptome-based miRNA-mRNA network analysis revealed the mechanism of inflammation-immunosuppressive damage caused by cadmium in common carp spleens. Sci Total Environ 717:137081

    Article  CAS  Google Scholar 

  12. Han Q, Zhang JY, Sun Q, Xu YM, Teng XH (2020) Oxidative stress and mitochondrial dysfunction involved in ammonia-induced nephrocyte necroptosis in chickens. Ecotoxicol Environ Saf 203:110974

    Article  CAS  Google Scholar 

  13. Shah SWA, Chen DC, Zhang JY, Liu YL, Ishfaq M, Tang Y, Teng XH (2020) The effect of ammonia exposure on energy metabolism and mitochondrial dynamic proteins in chicken thymus: through oxidative stress, apoptosis, and autophagy. Ecotoxicol Environ Saf 206:111413

    Article  CAS  Google Scholar 

  14. Chen JQ, Xu YM, Han Q, Yao YC, Xing HJ, Teng XH (2019) Immunosuppression, oxidative stress, and glycometabolism disorder caused by cadmium in common carp (Cyprinus carpio L.): application of transcriptome analysis in risk assessment of environmental contaminant cadmium. J Hazard Mater 366:386–394

    Article  CAS  Google Scholar 

  15. Song CJ, Gan SQ, He J, Shen XY (2021) Effects of nano-zinc on immune function in Qianbei-pockmarked goats. Biol Trace Elem Res 199(2):578–584

    Article  CAS  Google Scholar 

  16. Shen XY, Huo B, Gan SQ (2020) Effects of nano-selenium on antioxidant capacity in Se-deprived Tibetan Gazelle (Procapra picticaudata) in the Qinghai-Tibet Plateau. Biol Trace Elem Res 199(3):981–988

    Article  Google Scholar 

  17. Zhu ZM, Chen JB, Li TX, Chen L, Ma DH (2011) Resource and environmental significance of heavy metals in Lala copper mine tailings. Rock Miner Anal 30(1):43–48

    CAS  Google Scholar 

  18. Li YF, Wang YC, Shen XY (2021) Effects of sulfur fertilization on antioxidant capacity of Wumeng semi-fine wool sheep in the Wumeng Prairie. Pol J Environ Stud https://doi.org/10.15244/pjoes/132792

  19. Bao SD (2000) Soil agrochemical analysis [M]. China Agricultural Publishing House, Beijing, pp 22–42

    Google Scholar 

  20. GB 15618–2018. Soil environmental quality risk control standard of soil contamination of agricultural land (trial). Beijing, Ministry of Ecology and Environment of the People’s Republic of China

  21. Kan XQ, Dong YQ, Feng L, Zhou M, Hou HB (2021) Contamination and health risk assessment of heavy metals in China’s lead-zinc mine tailings: a meta-analysis. Chemosphere 267:128909

    Article  CAS  Google Scholar 

  22. Pott EB, Henry PR, Zanett MA, Rao PV, JrEJ H, Ammerman CB (1999) Effects of high dietary molybdenum concentration and duration of feeding time on molybdenum and copper metabolism in sheep. Anim Feed Sci Technol 79(1–2):93–105

    Article  CAS  Google Scholar 

  23. Heidari AH, Zamiri MJ, Nazem MN, Shirazi MRJ, Akhlaghi A, Pirsaraei ZA (2021) Detrimental effects of long-term exposure to heavy metals on histology, size and trace elements of testes and sperm parameters in Kermani sheep. Ecotoxicol Environ Saf 207:111563

    Article  CAS  Google Scholar 

  24. Nishito Y, Kambe T (2018) Absorption mechanisms of iron, copper, and zinc: an overview. J Nutr Sci Vitam 6(1):1–7

    Article  Google Scholar 

  25. Li YF, He J, Shen XY (2020) Effects of nano-selenium poisoning on immune function in the Wumeng semi-fine wool sheep. Biol Trace Elem Res 199(8):2919–2924

    Article  Google Scholar 

  26. Zhang D (2015) Cadmium poisoning and mechanism of zinc on cadmium poisoning. Huazhong Agricultural University, Wuhan

    Google Scholar 

  27. Chen DC, Ning FY, Zhang JY, Tang Y, Teng XH (2020) NF-κB pathway took part in the development of apoptosis mediated by miR-15a and oxidative stress via mitochondrial pathway in ammonia-treated chicken splenic lymphocytes. Sci Total Environ 729:139017

    Article  CAS  Google Scholar 

  28. Li Z, Shah SWA, Zhou Q, Yin XJ, Teng XH (2021) The contributions of miR-25–3p, oxidative stress, and heat shock protein in a complex mechanism of autophagy caused by pollutant cadmium in common carp (Cyprinus carpio L.) hepatopancreas. Environ Pollut 287:117554

    Article  CAS  Google Scholar 

  29. Liu LL, Yang BY, Cheng YP, Lin HJ (2015) Ameliorative effects of selenium on cadmium-induced oxidative stress and endoplasmic reticulum stress in the chicken kidney. Biol Trace Elem Res 167(2):308–319

    Article  CAS  Google Scholar 

  30. Feng Y (2020) Effect of hydroxyapatite on cadmium immobilization and rhizosphere microbial diversity in cadmium contaminated soil. Hebei University, Baoding

    Google Scholar 

  31. Chi YK, Zhang ZZ, Song CJ, Xiong KN, Shen XY (2020) Effects of fertilization on physiological and biochemical parameters of Wumeng sheep in China’s Wumeng Prairie. Pol J Environ Stud 29(1):79–85

    Article  CAS  Google Scholar 

  32. Chen JQ, Chen DC, Li JX, Liu YL, Gu XH, Teng XH (2021) Cadmium-induced oxidative stress and immunosuppression mediated mitochondrial apoptosis via JNK-FoxO3a-PUMA pathway in common carp (Cyprinus carpio L.) gills. Aquat Toxicol 233:105775

    Article  CAS  Google Scholar 

  33. Zhang JQ, Zheng SF, Wang SC, Liu QQ, Xu SW (2020) Cadmium-induced oxidative stress promotes apoptosis and necrosis through the regulation of the miR-216a-PI3K/AKT axis in commoncarp lymphocytes and antagonized by selenium. Chemosphere 258:127341

    Article  CAS  Google Scholar 

  34. Li YF, He J, Shen XY, Zhao K (2021) Effects of foliar application of nano-molybdenum fertilizer on copper metabolism of grazing Chinese Merino sheep (Junken type) on natural grasslands under copper and cadmium stress. Biol Trace Elem Res. https://doi.org/10.1007/s12011-021-02889-7

    Article  PubMed  PubMed Central  Google Scholar 

  35. Guo JM, Xing HJ, Cai JZ, Zhang HF, Xu SW (2021) H2S exposure-induced oxidative stress promotes LPS-mediated hepatocyte autophagy through the PI3K/AKT/TOR pathway. Ecotoxicol Environ Saf 209:111801

    Article  CAS  Google Scholar 

  36. Pilarczyk B, Jankowiak D, Tomza-Marciniak A, Pilarczyk R, Sablik P, Drozd R, Tylkowska A, Skolmowska M (2012) Selenium concentration and glutathione peroxidase (GSH-Px) activity in serum of cows at different stages of lactation. Biol Trace Elem Res 147:91–96

    Article  CAS  Google Scholar 

  37. Jiao WY, Han Q, Xu YM, Jiang HJ, Xing HJ, Teng XH (2019) Impaired immune function and structural integrity in the gills of common carp (Cyprinuscarpio L.) caused by Chlorpyrifos exposure: through oxidative stress and apoptosis. Fish Shellfish Immun 86:239–245

    Article  CAS  Google Scholar 

  38. Song N, Li XJ, Cui Y, Zhang TY, Xu SW, Li S (2021) Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631–5p/DUSP6 crosstalk on ROS production. J Hazard Mater 418:126172

    Article  CAS  Google Scholar 

Download references

Funding

This work was supported by Research and Application of Key Technologies for Safe Low Excretion Feed Production in Large-scale Pig Farms (2018NZ0046).

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Authors and Affiliations

  1. College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, China

    Yuanfeng Li, Jian He, Qionglian Zhang & Yachao Wang

  2. Swine Research Institute, Tie Qi Li Shi Group Co., Mianyang, 621006, China

    Yuanfeng Li & Lian Li

Authors
  1. Yuanfeng Li
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  2. Jian He
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  3. Qionglian Zhang
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  4. Lian Li
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  5. Yachao Wang
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Contributions

Yuanfeng Li: Conceptualization, methodology, preparation, investigation, software, data curation, formal analysis, writing-original draft. Jian He: Preparation, investigation, formal analysis, resources, funding acquisition. Qionglian Zhang: Conceptualization, investigation, data curation, writing-original draft. Lian Li: Supervision, conceptualization, methodology, project administration, resources. Yachao Wang: Visualization, investigation, software, formal analysis, resources, writing-reviewing and editing.

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Correspondence to Yachao Wang.

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The protocol for the present experiment was approved by the Institutional Animal Care and Use Committee of Southwest University of Science and Technology (SWUST20210185).

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Yuanfeng Li, Jian He and Qionglian Zhang are Equal contributors, they are co-first authors.

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Li, Y., He, J., Zhang, Q. et al. Nano-Molybdenum and Macleaya cordata Extracts Improved Antioxidant Capacity of Grazing Nanjiang Brown Goats on Copper and Cadmium-Contaminated Prairies. Biol Trace Elem Res 200, 2734–2740 (2022). https://doi.org/10.1007/s12011-021-02915-8

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