Abstract
In this study, green and eco-friendly biosynthesis of selenium nanoparticles (Se-NPs) were performed using Penicillium expansum ATTC 36200 for multiple biomedical applications. Mycosynthesized Se-NPs were completely characterized using UV, FT-IR, XRD, SEM, and TEM techniques. Se-NPs biosynthesized by P. expansum was characterized as a spherical shape with average size 4 to 12.7 nm. Moreover, Se-NPs were evaluated for multiple biomedical applications as antimicrobial, antioxidant, and anticancer activities and hemocompatibility. Results illustrated that Se-NPs have potential antimicrobial activity against Gram-positive (Bacillus subtilis ATCC6051 and Staphylococcus aureus ATCC23235), Gram-negative bacteria (Escherichia coli ATCC8739and Pseudomonas aeruginosa ATCC9027), fungi (Candida albicans ATCC90028, Aspergillus niger RCMB 02724 and Aspergillus fumigatus RCMB 02568), and antioxidant activity. Additionally, Se-NPs exhibited anticancer activity against PC3 cell line; IC50 was 99.25 μg/mL. Meanwhile, they showed non-hemolytic activity on human RBCs at concentration up to 250 μg/mL. In conclusion, biosynthetic Se-NPs by P. expansum are promising for many safe-use biomedical applications.
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The data used to support the findings of this study are available from the corresponding author upon request.
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Hashem, A.H., Khalil, A.M.A., Reyad, A.M. et al. Biomedical Applications of Mycosynthesized Selenium Nanoparticles Using Penicillium expansum ATTC 36200. Biol Trace Elem Res 199, 3998–4008 (2021). https://doi.org/10.1007/s12011-020-02506-z
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DOI: https://doi.org/10.1007/s12011-020-02506-z