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Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats

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Abstract

There is now substantial epidemiological evidence that diabetes is a risk factor for cerebrovascular disease. The protection by vanadium from focal cerebral ischemia in diabetic rats was studied in this paper. Rats with streptozotocin-induced diabetes were subjected to middle cerebral artery occlusion followed by 4 weeks of administration of 0.6 mg/ml sodium orthovanadate in drinking water. Vanadium significantly improved the outcome in diabetic rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. Vanadium reduces brain damage in streptozotocin-induced diabetic rats by imitating action of insulin.

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Acknowledgment

This work was supported by the Key New Drugs Innovation project from Ministry of Science and Technology (2009ZX09502-017), Program for New Century Excellent Talents in University (NCET-10-0273), Beijing Nova Program (2010B035), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, Young Scientist project from IPCAS (08CX043004), NNSF grant (30800301), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).

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Authors and Affiliations

  1. School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, 100102, China

    Zhenquan Liu, Pengtao Li, Dan Zhao & Huiling Tang

  2. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China

    Jianyou Guo

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  1. Zhenquan Liu
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  2. Pengtao Li
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Correspondence to Jianyou Guo.

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Liu, Z., Li, P., Zhao, D. et al. Protection by Vanadium, a Contemporary Treatment Approach to Both Diabetes and Focal Cerebral Ischemia in Rats. Biol Trace Elem Res 145, 66–70 (2012). https://doi.org/10.1007/s12011-011-9168-9

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  • DOI: https://doi.org/10.1007/s12011-011-9168-9

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