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Effects of Zinc Glycine Chelate on Oxidative Stress, Contents of Trace Elements, and Intestinal Morphology in Broilers

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Abstract

Three hundred and sixty healthy Ross × Ross 1-day-old broilers were used to study the effects of zinc glycine chelate (Zn-Gly) on oxidative stress, contents of trace elements, and intestinal morphology. All broilers were randomly assigned to six treatment groups, which replicates three times. Diets were as follows: (1) control (containing 29.3 mg zinc (Zn)/kg basic diet (0–21 days) and 27.8 mg Zn/kg (22–42 days)); (2) basic diet plus 30 mg Zn/kg from Zn-Gly; (3) basic diet plus 60 mg Zn/kg from Zn-Gly; (4) basic diet plus 90 mg Zn/kg from Zn-Gly; (5) basic diet plus 120 mg Zn/kg from Zn-Gly; and (6) positive control, basic diet plus 120 mg Zn/kg from zinc sulfate (ZnSO4). The results showed that the addition of 90 or 120 mg/kg Zn-Gly led to an improvement of activity of Cu/Zn superoxide dismutase and glutathione peroxidase and a reduction of malondialdehyde content in livers at 21 and 42 days. With 90 mg/kg Zn-Gly, the content of sera zinc increased by 17.55% (P < 0.05) in 21-day broilers and 10.77% (P > 0.05) in 42-day broilers compared with that of the control. Adding 120 mg/kg Zn-Gly or ZnSO4 to broilers' diets greatly enhanced the content of zinc in feces at 21 days (P < 0.05) and at 42 days (P < 0.05). For 42-day chickens, increased villus height and decreased crypt depth of the jejunum could be observed in the second growth stage of broilers fed with 90 mg/kg Zn-Gly. Also, intestinal wall thickness decreased (P < 0.05). In addition, adding 90 mg/kg Zn-Gly to the diet markedly elevated villus length of duodenum and decreased crypt depth of ileum (P < 0.05) in 42-day broilers.

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Acknowledgements

This work was supported by Grant Agreement 2004CB117506, a Key Science Project“973” Award from National Science and Technology Committee, and by Grant Agreement 2009C02007-2, a Key Science Project Award from Zhejiang province Science and Technology Committee, People's Republic of China. The authors would like to thank the Weifeng Bio.Corporation, China, for providing food grade zinc glycine chelate for this research.

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  1. The Key Laboratory of Molecular Animal Nutrition, College of Animal Science, Hua Jia Chi Campus, Zhejiang University, 164 Qiu Tao North Road, 310029, Hangzhou, China

    Wenqiang Ma, Haihua Niu, Jiang Feng, Yong Wang & Jie Feng

  2. The Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

    Wenqiang Ma

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  1. Wenqiang Ma
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Correspondence to Jie Feng.

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Ma, W., Niu, H., Feng, J. et al. Effects of Zinc Glycine Chelate on Oxidative Stress, Contents of Trace Elements, and Intestinal Morphology in Broilers. Biol Trace Elem Res 142, 546–556 (2011). https://doi.org/10.1007/s12011-010-8824-9

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