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Age-Related Changes of Elements in Human Olfactory Bulbs and Tracts and Relationships Among Their Contents

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Abstract

To elucidate compositional changes of the olfactory bulb and tract with aging, the authors investigated age-related changes of elements in the olfactory bulbs and tracts of Japanese and the relationships among the elements. After ordinary dissection at Nara Medical University was finished, the olfactory bulbs were resected with the olfactory tracts from 40 subjects. The subjects consisted of 15 men and 25 women, ranging in age from 65 to 102 years (average age = 84.6 ± 7.5 years). After ashing with nitric acid and perchloric acid, element contents in the olfactory bulbs and tracts were analyzed by inductively coupled plasma-atomic emission spectrometry. Seven elements of Ca, P, S, Mg, Zn, Fe, and Na did not change significantly in the olfactory bulbs and tracts with aging. The Ca, P, and S contents of major elements were less than 10 mg/g in all of the olfactory bulbs and tracts. Regarding the relationships among the elements, extremely or very significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na in the olfactory bulbs and tracts, with one exception. In addition, an extremely significant direct correlation was found between S and Mg contents and a very significant direct correlation was found between P and S contents. As P increased in the olfactory bulb and tract, Ca, Mg, Zn, Na, and S also increased in the olfactory bulb and tract.

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Authors and Affiliations

  1. Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara, 634-8521, Japan

    Lining Ke, Setsuko Tohno, Yoshiyuki Tohno, Cho Azuma & Yumi Moriwake

  2. Department of Anatomy, Histology, and Embryology, Fujian Medical University, Fuzhou, Fujian, 350004, China

    Lining Ke & Wei Wang

  3. Laboratory of Environmental Biology, Department of Life Science, Faculty of Science and Engineering, Kinki University, Higashi-Osaka, Osaka, 577-8502, Japan

    Takeshi Minami

  4. Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Nutcharin Ongkana

Authors
  1. Lining Ke
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  2. Setsuko Tohno
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  3. Yoshiyuki Tohno
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  4. Cho Azuma
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  5. Yumi Moriwake
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  6. Takeshi Minami
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  7. Nutcharin Ongkana
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  8. Wei Wang
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Correspondence to Yoshiyuki Tohno.

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Ke, L., Tohno, S., Tohno, Y. et al. Age-Related Changes of Elements in Human Olfactory Bulbs and Tracts and Relationships Among Their Contents. Biol Trace Elem Res 126, 65–75 (2008). https://doi.org/10.1007/s12011-008-8187-7

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  • DOI: https://doi.org/10.1007/s12011-008-8187-7

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