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Age-related Changes of Elements in Human Corpus Callosum and Relationships Among These Elements

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Abstract

To elucidate compositional changes of the corpus callosum with aging, the authors investigated age-related changes of elements and relationships with their element contents in the corpus callosum. After ordinary dissection by medical students at Nara Medical University was finished, the genu, trunk, and splenium of the corpus callosum were resected from the subjects ranging in age from 58 to 94 years. The element contents of the corpus callosum were determined by inductively coupled plasma-atomic emission spectrometry. The contents of Ca, P, S, Mg, Zn, Fe, and Na did not change significantly in the genu, trunk, and splenium of the corpus callosum with aging. Regarding the relationships among the element contents, significant correlations were found among the contents of Ca, P, S, Mg, and Fe in all of the genu, trunk, and splenium of the corpus callosum with some exceptions.

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Acknowledgement

Portions of this work were supported by a Grant-in-Aid for Scientific Research no. 17200032 from Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara, 634-8521, Japan

    Setsuko Tohno, Cho Azuma, Yoshiyuki Tohno, Yumi Moriwake & Atsuko Izu

  2. Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand

    Nutcharin Ongkana & Pasuk Mahakkanukrauh

  3. Laboratory of Environmental Biology, Department of Life Science, Faculty of Science and Engineering, Kinki University, Higashi-Osaka, Osaka, 577-8502, Japan

    Takeshi Minami

Authors
  1. Setsuko Tohno
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  2. Cho Azuma
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  3. Nutcharin Ongkana
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  4. Yoshiyuki Tohno
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  5. Pasuk Mahakkanukrauh
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  6. Yumi Moriwake
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  7. Atsuko Izu
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  8. Takeshi Minami
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Correspondence to Yoshiyuki Tohno.

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Tohno, S., Azuma, C., Ongkana, N. et al. Age-related Changes of Elements in Human Corpus Callosum and Relationships Among These Elements. Biol Trace Elem Res 121, 124–133 (2008). https://doi.org/10.1007/s12011-007-8037-z

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  • DOI: https://doi.org/10.1007/s12011-007-8037-z

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