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Lifelong Consumption of Sodium Selenite: Gender Differences on Blood–Brain Barrier Permeability in Convulsive, Hypoglycemic Rats

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Abstract

The aim of this study was to compare the effects of hypoglycemia and induced convulsions on the blood–brain barrier permeability in rats with or without lifelong administration of sodium selenite. There is a significant decrease of the blood–brain barrier permeability in three brain regions of convulsive, hypoglycemic male rats treated with sodium selenite when compared to sex-matched untreated rats (p < 0.05), but the decrease was not significant in female rats (p > 0.05). The blood–brain barrier permeability of the left and right hemispheres of untreated, moderately hypoglycemic convulsive rats of both genders was better than their untreated counterparts (p < 0.05). Our results suggest that moderate hypoglycemia and lifelong treatment with sodium selenite have a protective effect against blood–brain barrier permeability during convulsions and that the effects of sodium selenite are gender-dependent.

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Acknowledgements

This study was supported by the Research Fund of University of Istanbul. Project number: BYP-136/201202.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Dentistry, Istanbul University, Capa, Istanbul, Turkey

    F. Burcu Seker

  2. Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa, 34390, Istanbul, Turkey

    Sibel Akgul & Baria Oztas

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  1. F. Burcu Seker
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  2. Sibel Akgul
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  3. Baria Oztas
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Correspondence to F. Burcu Seker.

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Seker, F.B., Akgul, S. & Oztas, B. Lifelong Consumption of Sodium Selenite: Gender Differences on Blood–Brain Barrier Permeability in Convulsive, Hypoglycemic Rats. Biol Trace Elem Res 124, 12–19 (2008). https://doi.org/10.1007/s12011-008-8101-3

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  • DOI: https://doi.org/10.1007/s12011-008-8101-3

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