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Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma

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Abstract

Oral squamous cell carcinoma (OSCC) is a multistep process which is modulated by several endogenous and environmental factors. Epigenetic changes have been found to be equally responsible for OSCC as genetic changes. A plethora of genes showing hypermethylation have been discovered in OSCC. Since these changes are reversible, a lot of emphasis is on using the natural compounds for their ability to cause demethylation which could lead to reactivation of the inactivated tumor suppressor genes. This review encompasses the promoter hypermethylation of tumor suppressor genes in OSCC and its possible reversal using natural compounds. In addition, new compounds which could be screened for their demethylating ability have also been proposed.

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Acknowledgments

The authors acknowledge the help provided by the Department of Zoology, Delhi University, Delhi (India), and Department of Biotechnology, IMS Engineering College, U.P. (India).

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    Authors and Affiliations

    1. Department of Zoology, Delhi University, New Delhi, Delhi, 110007, India

      Meenakshi Jha & Anju Shrivastava

    2. Department of Biotechnology, IMS Engineering College, Ghaziabad, Uttar Pradesh, 201009, India

      Ruchi Aggarwal & Abhimanyu Kumar Jha

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    1. Meenakshi Jha
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    Correspondence to Abhimanyu Kumar Jha or Anju Shrivastava.

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    Meenakshi Jha and Ruchi Aggarwal contributed equally to this work.

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    Jha, M., Aggarwal, R., Jha, A.K. et al. Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma. Appl Biochem Biotechnol 177, 577–594 (2015). https://doi.org/10.1007/s12010-015-1768-y

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