Abstract
Background
Hip fractures in the elderly are common and associated with considerable mortality and disability. Although well known in industrialized countries, the factors associated with mortality after hip fractures are not reported frequently in developing countries and little is known regarding risk factors in Latin America.
Questions/Purpose
We investigated the rate of 1-year mortality and prefracture and fracture characteristics associated with mortality after a hip fracture in elderly Brazilian patients in a large metropolitan area.
Methods
Two hundred forty-six persons 60 years and older admitted to four hospitals in Rio de Janeiro were included after experiencing fractures and were followed for 1 year. Data were collected on sociodemographic, health, and functional status; type of surgery; length of stay; and complications after surgery. Cox regression analyses were conducted to investigate factors associated with 1-year mortality after hip fracture.
Results
Of the 246 patients, 86 died (35%). Of those 86, 22 died in the hospital (25.6%) and 64 (74.4%) died after discharge. Functional status before fracture, older age, male gender, and higher surgical risk increased the risk of mortality, whereas the use of antibiotics and the use of physical therapy after surgery decreased the risk.
Conclusions
Our mortality rate was higher than those reported from industrialized countries. The use of antibiotics and physical therapy are potentially modifiable factors to improve patients’ survival after fracture in Brazil.
Level of Evidence
Level II, prognostic study. See the Guidelines for Authors for a complete description of the levels of evidence.
Similar content being viewed by others
References
Alegre-Lopez J, Cordero-Guevara J, Alonso-Valdivielso JL, Fernandez-Melon J. Factors associated with mortality and functional disability after hip fracture: an inception cohort study. Osteoporos Int. 2005;16:729–736.
Bass E, French DD, Bradham DD. A national perspective of Medicare expenditures for elderly veterans with hip fractures. J Am Med Dir Assoc. 2008;9:114–119.
Beaupre LA, Jones CA, Saunders LD, Johnston DW, Buckingham J, Majumdar SR. Best practices for elderly hip fracture patients: a systematic overview of the evidence. J Gen Intern Med. 2005;20:1019–1025.
Berry SD, Samelson EJ, Hannan MT, McLean RR, Lu M, Cupples LA, Shaffer ML, Beiser AL, Kelly-Hayes M, Kiel DP. Second hip fracture in older men and women: the Framingham Study. Arch Intern Med. 2007;167:1971–1976.
Chudyk AM, Jutai JW, Petrella RJ, Speechley M. Systematic review of hip fracture rehabilitation practices in the elderly. Arch Phys Med Rehabil. 2009;90:246–262.
Cooper C, Atkinson EJ, Jacobsen SJ, O’Fallon WM, Melton LJ III. Population-based study of survival after osteoporotic fractures. Am J Epidemiol. 1993;137:1001–1005.
Cornwall R, Gilbert MS, Koval KJ, Strauss E, Siu AL. Functional outcomes and mortality vary among different types of hip fractures: a function of patient characteristics. Clin Orthop Relat Res. 2004;425:64–71.
Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002;359:1761–1767.
Dolan MM, Hawkes WG, Zimmerman SI, Morrison RS, Gruber-Baldini AL, Hebel JR, Magaziner J. Delirium on hospital admission in aged hip fracture patients: prediction of mortality and 2-year functional outcomes. J Gerontol A Biol Sci Med Sci. 2000;55:M527–M534.
Farahmand BY, Michaelsson K, Ahlbom A, Ljunghall S, Baron JA; Swedish Hip Fracture Study Group. Survival after hip fracture. Osteoporos Int. 2005;16:1583–1590.
Fortes EM, Raffaelli MP, Bracco OL, Takata ET, Reis FB, Santili C, Lazaretti-Castro M. [High morbidity-mortality and reduced level of osteoporosis diagnosis among elderly people who had hip fractures in Sao Paulo City] [in Portuguese]. Arq Bras Endocrinol Metabol. 2008;52:1106–1114.
Franzo A, Francescutti C, Simon G. Risk factors correlated with post-operative mortality for hip fracture surgery in the elderly: a population-based approach. Eur J Epidemiol. 2005;20:985–991.
Furlaneto ME, Garcez-Leme LE. Delirium in elderly individuals with hip fracture: causes, incidence, prevalence, and risk factors. Clinics. 2006;61:35–40.
Furlaneto ME, Garcez-Leme LE. Impact of delirium on mortality and cognitive and functional performance among elderly people with femoral fractures. Clinics. 2007;62:545–552.
Garcia R, Leme MD, Garcez-Leme LE. Evolution of Brazilian elderly with hip fracture secondary to a fall. Clinics. 2006;61:539–544.
Gdalevich M, Cohen D, Yosef D, Tauber C. Morbidity and mortality after hip fracture: the impact of operative delay. Arch Orthop Trauma Surg. 2004;124:334–340.
Gillespie WJ, Walenkamp G. Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures. Cochrane Database Syst Rev. 2001;1:CD000244.
Giversen IM. Time trends of mortality after first hip fractures. Osteoporos Int. 2007;18:721–732.
Gullberg B, Johnell O, Kanis JA. World-wide projections for hip fracture. Osteoporos Int. 1997;7:407–413.
Haentjens P, Autier P, Barette M, Venken K, Vanderschueren D, Boonen S; Hip Fracture Study Group. Survival and functional outcome according to hip fracture type: a one-year prospective cohort study in elderly women with an intertrochanteric or femoral neck fracture. Bone. 2007;41:958–964.
Haleem S, Lutchman L, Mayahi R, Grice JE, Parker MJ. Mortality following hip fracture: trends and geographical variations over the last 40 years. Injury. 2008;39:1157–1163.
Handoll HH, Sherrington C. Mobilisation strategies after hip fracture surgery in adults. Cochrane Database Syst Rev.2007;1:CD001704.
Hannan EL, Magaziner J, Wang JJ, Eastwood EA, Silberzweig SB, Gilbert M, Morrison RS, McLaughlin MA, Orosz GM, Siu AL. Mortality and locomotion 6 months after hospitalization for hip fracture: risk factors and risk-adjusted hospital outcomes. JAMA. 2001;285:2736–2742.
Hasegawa Y, Suzuki S, Wingstrand H. Risk of mortality following hip fracture in Japan. J Orthop Sci. 2007;12:113–117.
Heinonen M, Karppi P, Huusko T, Kautiainen H, Sulkava R. Post-operative degree of mobilization at two weeks predicts one-year mortality after hip fracture. Aging Clin Exp Res. 2004;16:476–480.
Hommel A, Ulander K, Bjorkelund KB, Norrman PO, Wingstrand H, Thorngren KG. Influence of optimised treatment of people with hip fracture on time to operation, length of hospital stay, reoperations and mortality within 1 year. Injury. 2008;39:1164–1174.
Jacobsen SJ, Goldberg J, Miles TP, Brody JA, Stiers W, Rimm AA. Race and sex differences in mortality following fracture of the hip. Am J Public Health. 1992;82:1147–1150.
Jiang HX, Majumdar SR, Dick DA, Moreau M, Raso J, Otto DD, Johnston DW. Development and initial validation of a risk score for predicting in-hospital and 1-year mortality in patients with hip fractures. J Bone Miner Res. 2005;20:494–500.
Johnell O, Kanis JA. An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos Int. 2004;15:897–902.
Johnell O, Kanis J. Epidemiology of osteoporotic fractures. Osteoporos Int. 2005;16(suppl 2):S3–S7.
Johnell O, Kanis JA, Oden A, Sernbo I, Redlund-Johnell I, Petterson C, De Laet C, Jönsson B. Mortality after osteoporotic fractures. Osteoporos Int. 2004;15:38–42.
Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby AK. The components of excess mortality after hip fracture. Bone. 2003;32:468–473.
Karagiannis A, Papakitsou E, Dretakis K, Galanos A, Megas P, Lambiris E, Lyritis GP. Mortality rates of patients with a hip fracture in a southwestern district of Greece: ten-year follow-up with reference to the type of fracture. Calcif Tissue Int. 2006;78:72–77.
Kilgore ML, Morrisey MA, Becker DJ, Gary LC, Curtis JR, Saag KG, Yun H, Matthews R, Smith W, Taylor A, Arora T, Delzell E. Health care expenditures associated with skeletal fractures among Medicare beneficiaries, 1999–2005. J Bone Miner Res. 2009 May 19 [Epub ahead of print].
Lipschitz DA. Screening for nutritional status in the elderly. Prim Care. 1994;21:55–67.
Mesquita GV, Abreu Lima MALT, Santos AMR, Alves EM, Brito JNPO, Martins MCC. [Morbid-mortality in elderly due to proximal fractures of the femur] [in Portuguese]. Texto Contexto Enferm, Florianópolis. 2009;18:67–73.
Meyer HE, Tverdal A, Falch JA, Pedersen JI. Factors associated with mortality after hip fracture. Osteoporos Int. 2000;11:228–232.
Muniz CF, Arnaut AC, Yoshida M, Trelha CS. [Characterization of aged patients with proximal femoral fractures in a public school hospital care] [in Portuguese]. Revista Espaco para a Saude. 2007;8:33–38.
Muraki S, Yamamoto S, Ishibashi H, Nakamura K. Factors associated with mortality following hip fracture in Japan. J Bone Miner Metab. 2006;24:100–104.
Owens WD, Felts JA, Spitznagel EL Jr. ASA physical status classifications: a study of consistency of ratings. Anesthesiology. 1978;49:239–243.
Peixoto SV, Giatti L, Afradique ME, Lima-Costa MF. [Costs of public hospitalization among elderly in Brazil’s Unified Health System] [in Portuguese]. Epidemiologia e Servicos de Saude. 2004;13:239–246.
Penrod JD, Litke A, Hawkes WG, Magaziner J, Doucette JT, Koval KJ, Silberzweig SB, Egol KA, Siu AL. The association of race, gender, and comorbidity with mortality and function after hip fracture. J Gerontol A Biol Sci Med Sci. 2008;63:867–872.
Pinheiro RS, Coeli CM, Vidal EI, Camargo KR Jr. [Mortality after hip fracture] [in Portuguese] Cadernos Saúde Coletiva, Rio de Janeiro. 2006;14:327–336.
Rae HC, Harris IA, McEvoy L, Todorova T. Delay to surgery and mortality after hip fracture. ANZ J Surg. 2007;77:889–891.
Rocha MA, Azer HW, Nascimento VG. [Functional evolution of proximal femoral end fractures] [in Portuguese]. Acta Ortop Brás. 2008;17:17–21.
Roche JJ, Wenn RT, Sahota O, Moran CG. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ. 2005;331:1374.
Sakaki MH, Oliveira AR, Coelho FF, Leme LEG, Suzuki I, Amatuzzi MM. [Study of the proximal femoral fractures mortality in elderly patients] [in Portuguese]. Acta Ortop Brás. 2004;12:242–249.
Shyu YI, Chen MC, Liang J, Wu CC, Su JY. Predictors of functional recovery for hip fractured elders during 12 months following hospital discharge: a prospective study on a Taiwanese sample. Osteoporos Int. 2004;15:475–482.
Smektala R, Endres HG, Dasch B, Maier C, Trampisch HJ, Bonnaire F, Pientka L. The effect of time-to-surgery on outcome in elderly patients with proximal femoral fractures. BMC Musculoskelet Disord. 2008;9:171.
Souza RC, Pinheiro RS, Coeli CM, Camargo KR Jr. [The Charlson comorbidity index (CCI) for adjustment of hip fracture mortality in the elderly: analysis of the importance of recording secondary diagnoses] [in Portuguese]. Cad Saúde Pública, Rio de Janeiro. 2008;24:315–322.
Souza RC, Pinheiro RS, Coeli CM, Camargo KR Jr, Torres TZ. [Risk adjustment measures for mortality after hip fracture] [in Portuguese]. Rev Saúde Pública. 2007;41:625–631.
Tosteson AN, Gottlieb DJ, Radley DC, Fisher ES, Melton LJ III. Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int. 2007;18:1463–1472.
Veras RP. País Jovem com Cabelos Brancos [Young Country with White Hair]. Rio De Janeiro, Brazil: Relume Dumará; 1994.
Vestergaard P, Rejnmark L, Mosekilde L. Has mortality after a hip fracture increased? J Am Geriatr Soc. 2007;55:1720–1726.
Vestergaard P, Rejnmark L, Mosekilde L. Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications. Osteoporos Int. 2007;18:1583–1593.
Vidal EI, Coeli CM, Pinheiro RS, Camargo KR Jr. Mortality within 1 year after hip fracture surgical repair in the elderly according to postoperative period: a probabilistic record linkage study in Brazil. Osteoporos Int. 2006;17:1569–1576.
Vidal EI, Moreira-Filho DC, Coeli CM, Camargo KR Jr, Fukushima FB, Blais R. Hip fracture in the elderly: does counting time from fracture to surgery or from hospital admission to surgery matter when studying in-hospital mortality? Osteoporos Int. 2009;20:723–729.
Acknowledgments
We thank Rebecca Rupp for careful editing of the article. The design of the study and data collection were performed at the Federal University of Rio De Janeiro and the data analyses and preparation of the manuscript were performed at the Oswaldo Cruz Foundation and at the Solidage Research Group on Frailty and Aging, Montreal, Canada, when Dr. Pereira was a visiting fellow 2007–2008.
Author information
Authors and Affiliations
Corresponding author
Additional information
Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.
Each author certifies that his or her institution approved or waived approval for the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.
Mario A. Sayeg—Deceased.
About this article
Cite this article
Pereira, S.R.M., Puts, M.T.E., Portela, M.C. et al. The Impact of Prefracture and Hip Fracture Characteristics on Mortality in Older Persons in Brazil. Clin Orthop Relat Res 468, 1869–1883 (2010). https://doi.org/10.1007/s11999-009-1147-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11999-009-1147-5