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Erythromelalgia

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References and Recommended Reading

  1. Mork C, Asker CL, Salerud EG, Kvernebo K: Microvascular arteriovenous shunting is a probable pathogenetic mechanism in erythromelalgia. J Invest Dermatol 2000, 114:643–646.

    Article  PubMed  CAS  Google Scholar 

  2. Davis MD, Rooke TW, Sandroni P: Mechanisms other than shunting are likely contributing to the pathophysiology of erythromelalgia. J Invest Dermatol 2000, 115:1166–1167.

    Article  PubMed  CAS  Google Scholar 

  3. Davis M, Sandroni P, Harper CM, et al.: Neurophysiologic and vascular studies in erythromelalgia: a retrospective analysis. J Clin Neuromuscular Dis 1999, 1:57–63.

    Article  Google Scholar 

  4. Davis MD, O’Fallon WM, Rogers RS 3rd, Rooke TW: Natural history of erythromelalgia: presentation and outcome in 168 patients. Arch Dermatol 2000, 136:330–336. This paper reviews the presentation, natural history, and prognosis in 168 patients with erythromelalgia. In addition, a survey of patients documents quality of life scores, and tabulates their self-reported response to treatment.

    Article  PubMed  CAS  Google Scholar 

  5. Smith LA, Allen EV: Erythermalgia (erythromelalgia) of the extremities: a syndrome characterized by redness, heat and pain. Am Heart J 1938, 16:175–188. A historic description of the disease.

    Article  Google Scholar 

  6. Michiels JJ, Abels J, Steketee J, et al.: Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia. Ann Intern Med 1985, 102:466–471.

    PubMed  CAS  Google Scholar 

  7. Ongenae K, Janssens A, Noens L, et al.: Erythromelalgia: a clue to the diagnosis of polycythemia vera. Dermatology 1996, 192:408–410.

    Article  PubMed  CAS  Google Scholar 

  8. Muhiddin KA, Gallen IW, Harries S, Pearce VR: The use of capsaicin cream in a case of erythromelalgia. Postgrad Med J 1994, 70:841–843.

    PubMed  CAS  Google Scholar 

  9. Rudikoff D, Jaffe IA: Erythromelalgia: response to serotonin reuptake inhibitors. J Am Acad Dermatol 1997, 37:281–283.

    Article  PubMed  CAS  Google Scholar 

  10. Moiin A, Yashar SS, Sanchez JE, Yashar B: Treatment of erythromelalgia with a serotonin/noradrenalinereuptake inhibitor. Br J Dermatol 2002, 146:336–337.

    Article  PubMed  CAS  Google Scholar 

  11. Herskovitz S, Loh F, Berger AR, et al.: Erythromelalgia: association with hereditary sensory neuropathy and response to amitriptyline. Neurology 1993, 43:621–622.

    PubMed  CAS  Google Scholar 

  12. McGraw T, Kosek P: Erythromelalgia pain managed with gabapentin. Anesthesiology 1997, 86:988–990.

    Article  PubMed  CAS  Google Scholar 

  13. Bada JL: Treatment of erythromelalgia with propranolol. Lancet 1977, 2:412.

    Article  PubMed  CAS  Google Scholar 

  14. Drenth JP, Michiels JJ, Ozsoylu S: Acute secondary erythermalgia and hypertension in children. Erythermalgia Multidisciplinary Study Group. Eur J Pediatr 1995, 154:882–885.

    Article  PubMed  CAS  Google Scholar 

  15. Kvernebo K: 1998 Erythromelalgia—a condition caused by microvascular arteriovenous shunting. VASA J Vasc Dis 1998, suppl 51:1–39. This extensive document/thesis reviews all the literature available on erythromelalgia and postulates mechanisms of disease. It also provides information derived from studying 40 patients with this disease.

    Google Scholar 

  16. Littleford RC, Khan F, Belch JJ: Skin perfusion in patients with erythromelalgia. Eur J Clin Invest 1999, 29:588–593.

    Article  PubMed  CAS  Google Scholar 

  17. Kvernebo K, Seem E: Erythromelalgia--pathophysiological and therapeutic aspects. A preliminary report. J Oslo City Hosp 1987, 37:9–12.

    PubMed  CAS  Google Scholar 

  18. Conri CL, Azoulai P, Constans J, et al.: Erythromelalgia and low molecular weight heparin [in French]. Therapie 1994, 49:518–519.

    PubMed  CAS  Google Scholar 

  19. Ozsoylu S, Caner H, Gokalp A: Successful treatment of erythromelalgia with sodium nitroprusside. J Pediatr 1979, 94:619–621.

    PubMed  CAS  Google Scholar 

  20. Ozsoylu S, Coskun T: Sodium nitroprusside treatment in erythromelalgia. Eur J Pediatr 1984, 141:185–187.

    Article  PubMed  CAS  Google Scholar 

  21. Stone JD, Rivey MP, Allington DR: Nitroprusside treatment of erythromelalgia in an adolescent female. Ann Pharmacother 1997, 31:590–592.

    PubMed  CAS  Google Scholar 

  22. Davis MD, Sandroni P: Lidocaine patch for pain of erythromelalgia. Arch Dermatol 2002, 138:17–19.

    Article  PubMed  Google Scholar 

  23. Kuhnert SM, Phillips WJ, Davis MD: Lidocaine and mexiletine therapy for erythromelalgia. Arch Dermatol 1999, 135:1447–1449.

    Article  PubMed  CAS  Google Scholar 

  24. Stricker LJ, Green CR: Resolution of refractory symptoms of secondary erythermalgia with intermittent epidural bupivacaine. Reg Anesth Pain Med 2001, 26:488–490.

    Article  PubMed  CAS  Google Scholar 

  25. D’Angelo R, Cohen IT, Brandom BW: Continuous epidural infusion of bupivacaine and fentanyl for erythromelalgia in an adolescent. Anesth Analg 1992, 74:142–144.

    Article  PubMed  CAS  Google Scholar 

  26. Rauck RL, Naveira F, Speight KL, Smith BP: Refractory idiopathic erythromelalgia. Anesth Analg 1996, 82:1097–1101.

    Article  PubMed  CAS  Google Scholar 

  27. Mohr M, Schneider K, Grosche M, Hildebrandt J: Cervical epidural infusion of morphine and bupivacaine in severe erythromelalgia [in German]. Anasthesiol Intensivmed Notfallmed Schmerzther 1994, 29:371–374.

    PubMed  CAS  Google Scholar 

  28. Trapiella Martinez L, Quiros JF, Caminal Montero L, et al.: Treatment of erythromelalgia with buprenorphine [in Spanish]. Rev Clin Esp 1997, 197:792.

    PubMed  CAS  Google Scholar 

  29. Macres S, Richeimer S: Successful treatment of erythromelalgia with intrathecal hydromorphone and clonidine. Clin J Pain 2000, 16:310–313.

    Article  PubMed  CAS  Google Scholar 

  30. Kraus A: Erythromelalgia in a patient with systemic lupus erythematosus treated with clonazepam. J Rheumatol 1990, 17:120.

    PubMed  CAS  Google Scholar 

  31. Sakakibara R, Fukutake T, Kita K, Hattori T: Treatment of primary erythromelalgia with cyproheptadine. J Auton Nerv Syst 1996, 58:121–122.

    Article  PubMed  CAS  Google Scholar 

  32. Calderone DC, Finzi E: Treatment of primary erythromelalgia with piroxicam. J Am Acad Dermatol 1991, 24:145–146.

    Article  PubMed  CAS  Google Scholar 

  33. Pepper H: Primary erythermalgia. Report of a patient treated with methysergide maleate. JAMA 1968, 203:1066–1067.

    Article  PubMed  CAS  Google Scholar 

  34. Vendrell J, Nubiola A, Goday A, et al.: Erythromelalgia associated with acute diabetic neuropathy: an unusual condition. Diabetes Res 1988, 7:149–151.

    PubMed  CAS  Google Scholar 

  35. H’Mila R, Samoud A, Souid M, et al.: Erythermalgia: a rare vascular acrosyndrome [in French]. Arch Fr Pediatr 1991, 48:555–557.

    PubMed  CAS  Google Scholar 

  36. Guillet MH, Le Noach E, Milochau P, et al.: Familial erythermalgia treated with pizotifen [in French]. Ann Dermatol Venereol 1995, 122:777–779.

    PubMed  CAS  Google Scholar 

  37. Drenth JP, Michiels JJ: Treatment options in primary erythermalgia? Am J Hematol 1993, 43:154.

    Article  PubMed  CAS  Google Scholar 

  38. Kasapcopur O, Akkus S, Erdem A, et al.: Erythromelalgia associated with hypertension and leukocytoclastic vasculitis in a child. Clin Exp Rheumatol 1998, 16:184–186.

    PubMed  CAS  Google Scholar 

  39. Cimaz R, Rusconi R, Fossali E, Careddu P: Unexpected healing of cutaneous ulcers in a short child. Lancet 2001, 358:211–212.

    Article  PubMed  CAS  Google Scholar 

  40. Cohen JS: High-dose oral magnesium treatment of chronic, intractable erythromelalgia. Ann Pharmacother 2002, 36:255–260.

    Article  PubMed  Google Scholar 

  41. Confino I, Passwell JH, Padeh S: Erythromelalgia following influenza vaccine in a child. Clin Exp Rheumatol 1997, 15:111–113.

    PubMed  CAS  Google Scholar 

  42. Suh DH, Kim SD, Ahn JS, et al.: A case of erythromelalgia successfully controlled by systemic steroids and pentazocine—is it related to a unique subtype of neutrophilic dermatosis? J Dermatol 2000, 27:204–210.

    PubMed  CAS  Google Scholar 

  43. Postlethwaite JC: Lumbar sympathectomy. A retrospective study of 142 operations on 100 patients. Br J Surg 1973, 60:878–879.

    Article  PubMed  CAS  Google Scholar 

  44. Shiga T, Sakamoto A, Koizumi K, Ogawa R: Endoscopic thoracic sympathectomy for primary erythromelalgia in the upper extremities. Anesth Analg 1999, 88:865–866.

    Article  PubMed  CAS  Google Scholar 

  45. Takeda S, Tomaru T, Higuchi M: A case of primary erythromelalgia (erythermalgia) treated with neural blockade [in Japanese]. Masui 1989, 38:388–3893.

    PubMed  CAS  Google Scholar 

  46. Seishima M, Kanoh H, Izumi T, et al.: A refractory case of secondary erythermalgia successfully treated with lumbar sympathetic ganglion block. Br J Dermatol 2000, 143:868–872.

    Article  PubMed  CAS  Google Scholar 

  47. Zoppi M, Zamponi A, Pagni E, Buoncristiano U: A way to understand erythromelalgia. J Auton Nerv Syst 1985, 13:85–89.

    Article  PubMed  CAS  Google Scholar 

  48. Chakravarty K, Pharoah PD, Scott DG, Barker S: Erythromelalgia —the role of hypnotherapy. Postgrad Med J 1992, 68:44–46.

    Article  PubMed  CAS  Google Scholar 

  49. Graziotti PJ, Goucke CR: Control of intractable pain in erythromelalgia by using spinal cord stimulation. J Pain Symptom Manage 1993, 8:502–504.

    Article  PubMed  CAS  Google Scholar 

  50. Kandel EI: Stereotactic surgery of erythromelalgia. Stereotact Funct Neurosurg 1990, 54-55:96–100.

    Article  PubMed  CAS  Google Scholar 

  51. Sadighi PJ, Arbid EJ: Neurectomy for palliation of primary erythermalgia. Ann Vasc Surg 1995, 9:197–198.

    Article  PubMed  CAS  Google Scholar 

  52. Cohen JS: Erythromelalgia: new theories and new therapies. J Am Acad Dermatol 2000, 43:841–847. This article describes the availability of a support group, called The Erythromelalgia Association, which can be a valuable support to patients with erythromelalgia. The response of 16 patients to treatment are summarized.

    Article  PubMed  CAS  Google Scholar 

  53. van Genderen PJ, Michiels JJ, van Strik R, et al.: Platelet consumption in thrombocythemia complicated by erythromelalgia: reversal by aspirin. Thromb Haemost 1995, 73:210–204.

    PubMed  Google Scholar 

  54. Kuhnert SM, Phillips WJ, Davis MD: Lidocaine and mexiletine therapy for erythromelalgia. Arch Dermatol 1999, 135:1447–1449.

    Article  PubMed  CAS  Google Scholar 

  55. Mork C, Kvernebo K: Erythromelalgia—a mysterious condition? Arch Dermatol 2000, 136:406–409. This editorial provides a thoughtful insight into the controversies surrounding this syndrome.

    Article  PubMed  CAS  Google Scholar 

  56. MICROMEDEX Healthcare Series [software]. Greenwood Village, CO: MICROMEDEX.

  57. Dash’ian GG, Sungurov EB: The surgical treatment of erythromelalgia by the destruction of the inlet areas of the posterior spinal nerve roots [in Russian]. Zh Vopr Neirokhir Im N N Burdenko 1995, 2:14–15.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology and the Gonda Vascular Center, Mayo Clinic and Mayo Foundation, 200 First Street, SW, 55905, Rochester, MN, USA

    Mark D. P. Davis MD & Thom Rooke MD

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  1. Mark D. P. Davis MD
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  2. Thom Rooke MD
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Davis, M.D.P., Rooke, T. Erythromelalgia. Curr Treat Options Cardio Med 4, 207–222 (2002). https://doi.org/10.1007/s11936-002-0002-8

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  • DOI: https://doi.org/10.1007/s11936-002-0002-8

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