Skip to main content
SpringerLink
Log in

Category III chronic prostatitis/chronic pelvic pain syndrome: Insights from the national institutes of health chronic prostatitis collaborative research network studies

  • Published:
Current Urology Reports Aims and scope Submit manuscript

Abstract

Chronic prostatitis/chronic pelvic pain syndrome remains an enigmatic medical condition. Creation of the National Institutes of Health-funded Chronic Prostatitis Collaborative Research Network (CPCRN) has stimulated a renewed interest in research on and clinical aspects of chronic prostatitis/chronic pelvic pain syndrome. Landmark publications of the CPCRN document a decade of progress. Insights from these CPCRN studies have improved our management of chronic prostatitis/chronic pelvic pain syndrome and offer hope for continued progress.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Krieger JN, Nyberg L, Nickel JC: NIH consensus definition and classification of prostatitis. JAMA 1999, 282:236–237.

    Article  PubMed  CAS  Google Scholar 

  2. Schaeffer AJ, Datta NS, Fowler JE Jr, et al.: Overview summary statement: diagnosis and management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Urology 2002, 60(6 Suppl):1–4.

    Article  PubMed  Google Scholar 

  3. Litwin MS, McNaughton-Collins M, Fowler FJ Jr, et al.: The National Institutes of Health Chronic Prostatitis Symptom Index: development and validation of a new outcome measure. J Urol 1999, 162:369–375.

    Article  PubMed  CAS  Google Scholar 

  4. Propert KJ, Litwin MS, Wang Y, et al.: Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). Qual Life Res 2006, 15:299–305.

    Article  PubMed  CAS  Google Scholar 

  5. Nickel JC, McNaughton-Collins M, Litwin SM, et al.: Development and use of a validated outcome measure for prostatitis. J Clin Outcomes Manag 2001, 8:30–37.

    Google Scholar 

  6. McNaughton-Collins MM, O’Leary MP, Calhoun EA, et al.: The Spanish National Institutes of Health-Chronic Prostatitis Symptom Index: translation and linguistic validation. J Urol 2001, 166:1800–1803.

    Article  Google Scholar 

  7. Karakiewicz PI, Perrotte P, Valiquette L, et al.: French-Canadian linguistic validation of the NIH Chronic Prostatitis Symptom Index. Can J Urol 2005, 12:2764–2771.

    Google Scholar 

  8. Schaeffer AJ, Landis JR, Knauss JS, et al.: Demographic and clinical characteristics of men with chronic prostatitis: the NIH Chronic Prostatitis Cohort (CPC) study. J Urol 2002, 168:593–598.

    Article  PubMed  Google Scholar 

  9. Schaeffer AJ, Knauss JS, Landis JR, et al.: Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis: the NIH Chronic Prostatitis Cohort (CPC) study. J Urol 2002, 168:1048–1053.

    Article  PubMed  Google Scholar 

  10. Propert KJ, McNaughton-Collins M, Leiby BE, et al.: A prospective study of symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome: the National Institutes of Health Chronic Prostatitis Cohort study. J Urol 2006, 175:619–623.

    Article  PubMed  Google Scholar 

  11. Pontari MA, McNaughton-Collins M, O’Leary MP, et al.: A case-control study of risk factors in men with chronic pelvic pain syndrome. BJU Int 2005, 96:559–565.

    Article  PubMed  Google Scholar 

  12. Calhoun EA, McNaughton Collins M, Pontari MA, et al.: The economic impact of chronic prostatitis. Arch Intern Med 2004, 164:1231–1236.

    Article  PubMed  Google Scholar 

  13. McNaughton-Collins M, Pontari MA, O’Leary MP, et al.: Quality of life is impaired in men with chronic prostatitis: the Chronic Prostatitis Collaborative Research Network. J Gen Intern Med 2001, 16:656–662.

    Article  PubMed  CAS  Google Scholar 

  14. Tripp DA, Nickel JC, Landis JR, et al.: Predictors of quality of life and pain in CP/CPPS: findings from the NIH Chronic Prostatitis Cohort Study. BJU Int 2004, 94:1279–1282.

    Article  PubMed  Google Scholar 

  15. Tripp DA, Nickel JC, Wang Y, et al.: Catastrophizing and pain-contingent rest predict patient adjustment in men with chronic prostatitis/chronic pelvic pain syndrome. J Pain 2006, 7:697–708.

    Article  PubMed  Google Scholar 

  16. Nickel JC, Tripp DA, Chuai S, et al.: Biopsychosocial factors in quality of life in CP/CPPS [AUA abstract]. J Urol 2007 (in press).

  17. Smith KB, Pukall CF, Tripp DA, Nickel JC: Sexual and relationship functioning in men with chronic prostatitis/chronic pelvic pain syndrome and their partners. Arch Sex Behav 2007, 36:301–311.

    Article  PubMed  Google Scholar 

  18. Smith KB, Tripp DA, Pukall CF, Nickel JC: Predictors of sexual and relationship functioning in couples with chronic prostatitis/chronic pelvic pain syndrome. J Sex Med 2007, 4:733–734.

    Google Scholar 

  19. Shoskes DA, Landis JR, Wang Y, et al.: Impact of post-ejaculatory pain in men with category III chronic prostatitis/chronic pelvic pain syndrome (CPPS). J Urol 2004, 172:542–547.

    Article  PubMed  Google Scholar 

  20. Nickel JC, Alexander RB, Schaeffer AJ, et al.: Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls. J Urol 2003, 170:818–822.

    Article  PubMed  Google Scholar 

  21. Nickel JC, Shoskes D, Wang Y, et al.: How does the pre-and post-massage test (PPMT) 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/ chronic pelvic pain syndrome? J Urol 2006, 176:119–124.

    Article  PubMed  Google Scholar 

  22. Nadler RB, McNaughton-Collins M, Propert KJ, et al.: The prostate specific antigen (PSA) test is not helpful in the diagnostic evaluation of chronic prostatitis/chronic pelvic pain syndrome. Urology 2006, 67:337–342.

    Article  PubMed  Google Scholar 

  23. Nickel JC, Nyberg L, Hennenfent M: Research Guidelines for chronic prostatitis: a consensus report from the first National Institutes of Health-International Prostatitis Collaborative Network (NIH-IPCN). Urology 1999, 54:229–233.

    Article  PubMed  CAS  Google Scholar 

  24. Propert KJ, Alexander RB, Nickel JC, et al.: The design of a multi-center randomized clinical trial for chronic prostatitis/chronic pelvic pain syndrome. Urology 2002, 59:870–876.

    Article  PubMed  Google Scholar 

  25. Alexander RB, Propert KJ, Schaeffer AJ, et al.: Ciprofloxacin and tamsulosin in men with chronic prostatitis/chronic pelvic pain syndrome: a randomized, double-blind trial. Ann Intern Med 2004, 141:581–89.

    PubMed  CAS  Google Scholar 

  26. Trial to compare alfuzosin versus placebo in the treatment of chronic prostatitis/chronic pelvic pain syndrome. Available at http://clinicaltrials.gov/ct/show/NCT00103402?order=2. Accessed May 13, 2008.

  27. Efficacy and safety study of pregabalin to treat chronic prostatitis/chronic pelvic pain syndrome. Available at http://clinicaltrials.gov/ct/show/NCT00371033?order=1. Accessed May 13, 2008.

  28. McNaughton-Collins M, Calhoun EA, Clemens JQ, Litwin MS: Primary care physician practice patterns in the management of chronic prostatitis/chronic pelvic pain syndrome [AUA abstract]. J Urol 2007 (in press).

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Queen’s University, Kingston General Hospital, Kingston, Ontario, K7L 2V7, Canada

    J. Curtis Nickel

Authors
  1. J. Curtis Nickel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard B. Alexander
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rodney Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Richard Berger
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Craig V. Comiter
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nand S. Datta
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jackson E. Fowler
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. John N. Krieger
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. J. Richard Landis
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Mark S. Litwin
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Mary McNaughton-Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Michael P. O’Leary
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Michel A. Pontari
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Anthony J. Schaeffer
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Daniel A. Shoskes
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Paige White
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. John Kusek
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Leroy Nyberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

NIH-CPCRN Study Groups

Corresponding author

Correspondence to J. Curtis Nickel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nickel, J.C., Alexander, R.B., Anderson, R. et al. Category III chronic prostatitis/chronic pelvic pain syndrome: Insights from the national institutes of health chronic prostatitis collaborative research network studies. Curr Urol Rep 9, 320–327 (2008). https://doi.org/10.1007/s11934-008-0055-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11934-008-0055-7

Keywords

Search

Navigation