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Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI)

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Abstract

Objectives: The NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to assess symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We assessed the responsiveness of the NIH-CPSI to change over time and defined thresholds for changes perceptible to patients. Methods: We studied 174 men with CP/CPPS who participated in a placebo-controlled randomized clinical trial. Changes from baseline to six weeks in the NIH-CPSI total score and pain, urinary, and quality of life subscores were compared to a global response assessment (GRA). Effect sizes and Guyatt statistics were calculated to evaluate responsiveness; 95% confidence intervals were produced using bootstrapping. Results: All scores decreased over time with the largest decrease in subjects who reported on the GRA that they were markedly improved. The NIH-CPSI total, pain, and quality of life scores were highly responsive in the improved groups; the urinary score showed minimal responsiveness. There was no evidence of responsiveness among those subjects who worsened on the trial. ROC curves identified a 6-point decline in the NIH-CPSI total score as the optimal threshold to predict treatment response. Conclusions: The NIH-CPSI total score and pain and quality of life subscores are responsive to change over␣time.

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Authors and Affiliations

  1. Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    K. J. Propert & Y. Wang

  2. Departments of Urology and Health Services, David Geffen School of Medicine and School of Public Health, University of California, Los Angeles, CA, USA

    M. S. Litwin

  3. Division of Urology, University of Maryland School of Medicine, Baltimore, MD, USA

    R. B. Alexander

  4. Institute of Health Services Research and Health Policy Studies, and Department of Urology, Northwestern University Medical School, Chicago, IL, USA

    E. Calhoun

  5. Department of Urology, Queen’s University, Kingston, Canada

    J. C. Nickel

  6. Division of Urologic Surgery, Brigham and Women’s Hospital, Boston, MA, USA

    M. P. O’Leary

  7. Department of Urology, Temple University School of Medicine, USA

    M. Pontari

  8. General Medicine Division, Massachusetts General Hospital, Boston, MA, USA

    M. McNaughton-Collins

  9. Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Blockley Hall Room 614, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA

    K. J. Propert

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  1. K. J. Propert
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  2. M. S. Litwin
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  3. Y. Wang
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  4. R. B. Alexander
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  5. E. Calhoun
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  6. J. C. Nickel
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  7. M. P. O’Leary
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  8. M. Pontari
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  9. M. McNaughton-Collins
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the Chronic Prostatitis Collaborative Research Network (CPCRN)

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Correspondence to K. J. Propert.

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Propert, K.J., Litwin, M.S., Wang, Y. et al. Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). Qual Life Res 15, 299–305 (2006). https://doi.org/10.1007/s11136-005-1317-1

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  • DOI: https://doi.org/10.1007/s11136-005-1317-1

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