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Microbial Influences of Mucosal Immunity in Rheumatoid Arthritis

  • Rheumatoid Arthritis (L Moreland, Section Editor)
  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review will summarize recent data defining the relationship between rheumatoid arthritis (RA) and the microbiome at mucosal sites throughout the body. It will highlight what is known, what is speculated, and current knowledge gaps regarding the microbiome in RA.

Recent Findings

An extensive relationship between the microbiome and immune cell function can influence RA-related inflammation and T cell and B cell biology. Studies are beginning to characterize microbial changes in individuals who are at risk for RA, which is a critical element needed to understand the influence of the microbiome on RA pathogenesis.

Summary

Expanding our understanding of the microbiome in RA beyond the bacteria at the gut and oral mucosae into the lung and urogenital surfaces, including viral and fungal components, and establishing the relationship across mucosal sites will be critical in future work. Importantly, approaches to manipulate the microbiome could lead to novel therapeutic and preventive strategies.

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Authors and Affiliations

  1. Division of Rheumatology, University of Colorado Denver, 1775 Aurora Court, Mail Stop B-115, Aurora, CO, 80045, USA

    Timothy M. Wilson, Brandon Trent, Kristine A. Kuhn & M. Kristen Demoruelle

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  1. Timothy M. Wilson
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  2. Brandon Trent
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  3. Kristine A. Kuhn
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  4. M. Kristen Demoruelle
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Correspondence to M. Kristen Demoruelle.

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MKD has received research support from Pfizer Inc. on studies related to RA. All other authors have declared that no conflict of interest exists.

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This article is part of the Topical Collection on Rheumatoid Arthritis

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Wilson, T.M., Trent, B., Kuhn, K.A. et al. Microbial Influences of Mucosal Immunity in Rheumatoid Arthritis. Curr Rheumatol Rep 22, 83 (2020). https://doi.org/10.1007/s11926-020-00960-1

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