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RS3PE: Clinical and Research Development

  • Orphan Diseases (B Manger, Section Editor)
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Abstract

Remitting seronegative symmetrical synovitis with pitting edema or RS3PE is a rare elderly-onset rheumatic syndrome. Although there are overlapping clinical manifestations between RS3PE, elderly-onset rheumatoid arthritis, and polymyalgia rheumatica, RS3PE has distinct characteristics. RS3PE can be associated with neoplasia and various rheumatic conditions, suggesting that it may be heterogeneous, and is considered as a paraneoplastic rheumatic disease. The pathogenesis of RS3PE may involve vascular endothelial growth factor and infection in RS3PE based upon limited data. Patients with RS3PE without concomitant malignancy respond well to small doses of glucocorticoids and carry good prognosis.

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Conflict of Interest

Hongbin Li, Roy D. Altman, and Qingping Yao declare no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. The Division of Rheumatology, Inner Mongolia Medical University, Hohhot, China

    Hongbin Li

  2. The Division of Rheumatology, David Geffen Medical School at UCLA, Los Angeles, CA, USA

    Roy D. Altman

  3. The Department of Rheumatic and Immunologic Disease, Cleveland Clinic, Cleveland, OH, USA

    Qingping Yao

  4. The Division of Rheumatology, Allergy and Immunology, Stony Brook University, Stony Brook, NY, USA

    Qingping Yao

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  1. Hongbin Li
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  2. Roy D. Altman
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  3. Qingping Yao
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Correspondence to Qingping Yao.

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Li, H., Altman, R.D. & Yao, Q. RS3PE: Clinical and Research Development. Curr Rheumatol Rep 17, 49 (2015). https://doi.org/10.1007/s11926-015-0525-0

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