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Heat shock proteins in juvenile idiopathic arthritis: Keys for understanding remitting arthritis and candidate antigens for immune therapy

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Abstract

Juvenile idiopathic arthritis (JIA) is in a majority of the cases of self-limiting, and sometimes even a self-remitting, disease. A growing amount of data suggests that active T cell regulation determines, at least partly, the clinical outcome of JIA. In experimental models of arthritis, a group of highly conserved microbial proteins, heat shock proteins (hsps), can be used to effectively prevent and treat arthritis. This protection is mediated through the induction of cross-reactive T cell responses to self-hsps. In JIA, naturally occurring T cell immune responses to hsps are associated with disease remission in restricted oligoarticular JIA. Moreover, those responses are associated with the induction of T cells with a regulatory phenotype. Taken together, these data imply that immune modulation with hsps can be an effective way to restore natural occurring T cell responses, and, thus, treat JIA and rheumatoid arthritis.

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Authors and Affiliations

  1. Department of Pediatric Immunology, University Medical Center Utrecht, University Hospital for Children and Youth, PO Box 85090, 3508 AB, Utrecht, The Netherlands

    Berent Prakken MD, PhD

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  1. Berent Prakken MD, PhD
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  2. Wietse Kuis MD
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  3. Willem van Eden MD
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  4. Salvatore Albani MD
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Prakken, B., Kuis, W., Eden, W.v. et al. Heat shock proteins in juvenile idiopathic arthritis: Keys for understanding remitting arthritis and candidate antigens for immune therapy. Curr Rheumatol Rep 4, 466–473 (2002). https://doi.org/10.1007/s11926-002-0052-7

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  • DOI: https://doi.org/10.1007/s11926-002-0052-7

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