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Exercise in Treatment of Migraine Including Chronic Migraine

  • Chronic Daily Headache (S-J Wang, Section Editor)
  • Published:
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Abstract

Purpose of Review

With this review, we aimed to investigate the effect of exercise on migraine and explored the possibility of exercise as a treatment option for migraine.

Recent Findings

A close association of physical activity and exercise with migraine has been reported in clinical and population-based studies. Recent randomized controlled trials investigating the effect of aerobic exercise as a migraine-preventive treatment have revealed a notable improvement in migraine symptoms. Data on the effect of anaerobic exercise and exercise for flexibility, coordination, and relaxation on migraine are currently insufficient to make any recommendations. Possible pathways for the attenuation of migraine by exercise include the endogenous opioid and cannabinoid systems, brain-derived neurotrophic factor, inflammation, and behavioral/psychological factors.

Summary

Regarding efficacy, side effects, and health benefits, aerobic exercise is a potentially beneficial strategy in the preventive treatment of migraine. Further studies are needed to delineate an evidence-based exercise program for migraine treatment.

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Funding

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2019R1F1A1053841).

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Authors and Affiliations

  1. Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, South Korea

    Tae-Jin Song

  2. Department of Neurology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemoon-gu, Seoul, 03722, South Korea

    Min Kyung Chu

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  1. Tae-Jin Song
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Contributions

Tae-Jin Song: formal analysis, investigation, and writing—original draft

Min Kyung Chu: conceptualization, formal analysis, methodology, investigation, funding acquisition, writing (original draft), visualization, writing (review and editing)

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Correspondence to Min Kyung Chu.

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Conflict of Interest

Min Kyung Chu was a site investigator for a multicenter trial sponsored by Otsuka Korea, Novartis International AG, and Eli Lilly and Company. Min Kyung Chu worked an advisory member for Teva and received lecture honoraria from Allergan Korea and Yuyu Pharmaceutical Company in the past 24 months.

Tae-Jin Song declares no conflict of interest.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki Declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

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This article is part of the Topical Collection on Chronic Daily Headache

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Song, TJ., Chu, M.K. Exercise in Treatment of Migraine Including Chronic Migraine. Curr Pain Headache Rep 25, 14 (2021). https://doi.org/10.1007/s11916-020-00929-w

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